Catalog No.
YHE45401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly36-Ala294
Predicted molecular weight
30.11 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P45880
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Outer mitochondrial membrane protein porin 2, Voltage-dependent anion-selective channel protein 2, VDAC2, hVDAC2, VDAC-2
Note
For research use only.
Hepatocyte Deubiquitinating Enzyme OTUD5 Deficiency is a Key Aggravator for Metabolic Dysfunction-Associated Steatohepatitis by Disturbing Mitochondrial Homeostasis., PMID:38036082
Identification of postnatal development dependent genes and proteins in porcine epididymis., PMID:38049726
Phospholipids are imported into mitochondria by VDAC, a dimeric beta barrel scramblase., PMID:38065946
Chemoproteomics Reveals Glaucocalyxin A Induces Mitochondria-Dependent Apoptosis of Leukemia Cells via Covalently Binding to VDAC1., PMID:38105424
Mechanistic engineering of celastrol liposomes induces ferroptosis and apoptosis by directly targeting VDAC2 in hepatocellular carcinoma., PMID:38149060
Interactome Analysis Identifies the Role of BZW2 in Promoting Endoplasmic Reticulum-Mitochondria Contact and Mitochondrial Metabolism., PMID:38154691
Bakuchiol targets mitochondrial proteins, prohibitins and voltage-dependent anion channels: New insights into developing antiviral agents., PMID:38199573
The E3 ubiquitin ligase Itch regulates death receptor and cholesterol trafficking to affect TRAIL-mediated apoptosis., PMID:38216558
Quantum Sensing of Free Radical Generation in Mitochondria of Single Heart Muscle Cells during Hypoxia and Reoxygenation., PMID:38235677
A novel MTORC2-AKT-ROS axis triggers mitofission and mitophagy-associated execution of colorectal cancer cells upon drug-induced activation of mutant KRAS., PMID:38261660
RTN3 deficiency exacerbates cisplatin-induced acute kidney injury through the disruption of mitochondrial stability., PMID:38336146
Single-cell and bulk RNA sequencing data jointly reveals VDAC2's impacts on prognosis and immune landscape of NSCLC., PMID:38382091
Neuronal Protection by Ha-RAS-GTPase Signaling through Selective Downregulation of Plasmalemmal Voltage-Dependent Anion Channel-1., PMID:38474278
BRD4 inhibitors broadly promote erastin-induced ferroptosis in different cell lines by targeting ROS and FSP1., PMID:38565708
BmNPV p35 regulates apoptosis in Bombyx mori via a novel target of interaction with the BmVDAC2-BmRACK1 complex., PMID:38616030
Integrative analysis of proteomics and lipidomic profiles reveal the fat deposition and meat quality in Duroc × Guangdong small spotted pig., PMID:38659450
Key residues in the VDAC2-BAK complex can be targeted to modulate apoptosis., PMID:38696533
Biomarker Identification and Risk Prediction Model Development for Differentiated Thyroid Carcinoma Lung Metastasis Based on Primary Lesion Proteomics., PMID:38723277
Lamprey VDAC2: Suppressing hydrogen peroxide-induced 293T cell apoptosis by downregulating BAK expression., PMID:38740227
Quantum Sensing of Free Radical Generation in Mitochondria of Human Keratinocytes during UVB Exposure., PMID:38743437
TMX2 potentiates cell viability of hepatocellular carcinoma by promoting autophagy and mitophagy., PMID:38797513
Resveratrol Inhibits VDAC1-Mediated Mitochondrial Dysfunction to Mitigate Pathological Progression in Parkinson's Disease Model., PMID:38819635
Regulation of cardiac ferroptosis in diabetic human heart failure: uncovering molecular pathways and key targets., PMID:38824159
Intramolecular Disulfide Bridges in Voltage-Dependent Anion Channel 2 (VDAC2) Protein from Rattus norvegicus Revealed by High-Resolution Mass Spectrometry., PMID:38832804
TRIM8 promotes ovarian cancer proliferation and migration by targeting VDAC2 for ubiquitination and degradation., PMID:38881325
Melatonin regulates mitochondrial function to alleviate ferroptosis through the MT2/Akt signaling pathway in swine testicular cells., PMID:38956409
Coumestrol facilitates apoptosis in colorectal cancer cells by interacting with ZIP8 protein via the ferroptosis pathway., PMID:39006076
Dual-Probe Activity-Based Protein Profiling Reveals Site-Specific Differences in Protein Binding of EGFR-Directed Drugs., PMID:39052621
MiR-4769-3p suppresses adipogenesis in systemic sclerosis by negatively regulating the USP18/VDAC2 pathway., PMID:39156653
Sulindac prevents increased mitochondrial VDAC1 expression and cell surface mistargeting induced by pathological conditions in retinal cells., PMID:39181068
The expression of VDACs and Bcl2 family genes in pituitary adenomas: clinical correlations and postsurgical outcomes., PMID:39449743
Molecular and structural analyses of voltage-dependent anion channel 2 and its anti-apoptotic function in stress and pollutant resistance in Pacific abalone., PMID:39491697
Single-cell sequencing combined with transcriptomics and in vivo and in vitro analysis reveals the landscape of ferroptosis in myocardial ischemia-reperfusion injury., PMID:39520298
VRK2 inhibits the replication of infectious bursal disease virus by phosphorylating RACK1 and suppressing apoptosis., PMID:39579830
Differential expression of ferroptosis-related proteins in urinary exosomes: potential indicators for monitoring acute gout attack., PMID:39606034
GCRV-II major outer capsid protein VP4 promotes cell apoptosis by VDAC2-mediated calcium pathway facilitation., PMID:39631593
Developing a Novel and Optimized Yeast Model for Human VDAC Research., PMID:39684721
Isoglycyrrhizin supplementation of frozen goat semen-extender improves post-thaw sperm quality and in vitro fertilization rates., PMID:39693806
Hexokinase-I directly binds to a charged membrane-buried glutamate of mitochondrial VDAC1 and VDAC2., PMID:39930004
CgVDAC2 participated in haemocyte mitophagy induced by Vibrio splendidus in the Pacific oyster Crassostrea gigas., PMID:39993486
Predicting mito-target interactions for per-and poly-fluoroalkyl compounds: Mapping mitochondrial toxicity on zebrafish voltage-dependent anion channel 2., PMID:40024016
Differential regulation of BAX and BAK apoptotic activity revealed by small molecules., PMID:40043112
Synergetic effect of doxorubicin and avenanthramide C on VDAC2/MTCH1 mitochondrial axis in breast cancer cells., PMID:40046789
VDAC2 and Bak scarcity in liver mitochondria enables targeting hepatocarcinoma while sparing hepatocytes., PMID:40069152
Structure of human PINK1 at a mitochondrial TOM-VDAC array., PMID:40080546
VDAC2 loss elicits tumour destruction and inflammation for cancer therapy., PMID:40108474
C-Terminal Hsp90 Inhibitors Overcome MEK and BRAF Inhibitor Resistance in Melanoma., PMID:40135438
Conformational plasticity of mitochondrial VDAC2 controls the kinetics of its interaction with cytosolic proteins., PMID:40267181
Mitochondrial proteome basis for the biological variations in beef color stability of longissimus lumborum muscle differing in ultimate pH and packaging methods., PMID:40344784
Interactome of FMRP-N-tat therapeutic unveils key interactions for cellular function in Fragile X neurons., PMID:40480633
For research use only. Not for human or drug use.
