Catalog No.
YHK44601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ser211
Predicted molecular weight
26.50 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UI95
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Mitotic arrest deficient 2-like protein 2, Mitotic spindle assembly checkpoint protein MAD2B, MAD2L2, MAD2-like protein 2, hREV7, REV7, REV7 homolog, MAD2B
Note
For research use only.
Identification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens., PMID:33257658
Regulation of DNA double-strand break repair pathway choice: a new focus on 53BP1., PMID:33448186
Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex., PMID:33597306
Pathways and signatures of mutagenesis at targeted DNA nicks., PMID:33857147
REV7: Jack of many trades., PMID:33962851
Mitotic syndicates Aurora Kinase B (AURKB) and mitotic arrest deficient 2 like 2 (MAD2L2) in cohorts of DNA damage response (DDR) and tumorigenesis., PMID:34083040
Oxaliplatin promotes siMAD2L2‑induced apoptosis in colon cancer cells., PMID:34278473
MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair., PMID:34521823
Mitotic Arrest-Deficient 2 Like 2 (MAD2L2) Interacts with Escherichia coli Effector Protein EspF., PMID:34575120
A comprehensive molecular study identified 12 complementation groups with 56 novel FANC gene variants in Indian Fanconi anemia subjects., PMID:34585473
Inhibition of MAD2B alleviates venous neointimal formation by suppressing VSMCs proliferation and migration., PMID:34605572
Upregulation of REV7 correlates with progression of malignant melanoma., PMID:34637584
MAD2B-mediated cell cycle reentry of podocytes is involved in the pathogenesis of FSGS., PMID:34803506
Disrupting the MAD2L2-Rev1 Complex Enhances Cell Death upon DNA Damage., PMID:35163901
Single nucleotide polymorphisms to predict acute radiation dermatitis in breast cancer patients: A systematic review and meta-analysis., PMID:35301098
MAD2B promotes podocyte injury through regulating Numb-dependent Notch 1 pathway in diabetic nephropathy., PMID:35342338
Focal facial dermal dysplasias type III: Two families with Setleis syndrome in China., PMID:35713327
Analysis of Ser/Thr Kinase HASPIN-Interacting Proteins in the Spermatids., PMID:36012324
Role of the WNT/β-catenin/ZKSCAN3 Pathway in Regulating Chromosomal Instability in Colon Cancer Cell lines and Tissues., PMID:36012568
CHAMP1 binds to REV7/FANCV and promotes homologous recombination repair., PMID:36044844
MAD2L2 promotes replication fork protection and recovery in a shieldin-independent and REV3L-dependent manner., PMID:36075897
RNA-methyltransferase Nsun5 controls the maternal-to-zygotic transition by regulating maternal mRNA stability., PMID:36495115
Evolution of Rev7 interactions in eukaryotic TLS DNA polymerase Polζ., PMID:36592930
Inactivation of Mad2B Enhances Apoptosis in Human Cervical Cancer Cell Line upon Cisplatin-Induced DNA Damage., PMID:36642928
Bridging Gaps in HDR Improvement: The Role of MAD2L2, SCAI, and SCR7., PMID:37047677
Identification of the promoter region regulating the transcription of the REV7 gene., PMID:37094431
Backbone and ILV side-chain methyl NMR resonance assignments of human Rev7/Rev3-RBM1 and Rev7/Rev3-RBM2 complexes., PMID:37129702
Mad2B forms a complex with Cdc20, Cdc27, Rev3 and Rev1 in response to cisplatin-induced DNA damage., PMID:37641805
Identification of co-diagnostic effect genes for aortic dissection and metabolic syndrome by multiple machine learning algorithms., PMID:37684281
REV7 Monomer Is Unable to Participate in Double Strand Break Repair and Translesion Synthesis but Suppresses Mitotic Errors., PMID:37958783
The promoting effect and mechanism of MAD2L2 on stemness maintenance and malignant progression in glioma., PMID:38017538
Identification of a Novel CD8+ T cell exhaustion-related gene signature for predicting survival in hepatocellular carcinoma., PMID:38049741
MAD2L2, a key regulator in ovarian cancer and promoting tumor progression., PMID:38167649
AURKB promotes bladder cancer progression by deregulating the p53 DNA damage response pathway via MAD2L2., PMID:38515112
Analysis of translesion polymerases in colorectal cancer cells following cetuximab treatment: A network perspective., PMID:39102671
Probing hot spots of protein-protein interactions mediated by the safety-belt region of REV7., PMID:39366370
HNRNPD/MAD2L2 axis facilitates lung adenocarcinoma progression and is a potential prognostic biomarker., PMID:39366534
Somatic gene mutations involved in DNA damage response/Fanconi anemia signaling are tissue- and cell-type specific in human solid tumors., PMID:39421870
A pan-cancer study of ADAM9's immunological function and prognostic value particularly in liver cancer., PMID:39505907
MAD2L2 Dimerization Is Not Essential for Mitotic Regulation., PMID:39519037
Microglia-derived ADAM9 promote GHRH neurons pyroptosis by Mad2L2-JNK-caspase-1 pathway in subarachnoid hemorrhage., PMID:39563331
Elevated expression of REV7 correlates with poor prognosis in lung adenocarcinoma and its inactivation in carcinoma cells enhances chemosensitivity., PMID:39708518
High levels of REV7 expression are associated with poor prognosis and chemoresistance in gastric adenocarcinoma., PMID:39739346
REV7: a small but mighty regulator of genome maintenance and cancer development., PMID:39839778
Targeting the AURKB-MAD2L2 Axis Disrupts the DNA Damage Response and Glycolysis to Inhibit Colorectal Cancer Progression., PMID:40018943
POGZ targeted by LINC01355/miR-27b-3p retards thyroid cancer progression via interplaying with MAD2L2., PMID:40071126
REV7 functions with REV3 as a checkpoint protein delaying mitotic entry until DNA replication is completed., PMID:40106439
CST Is Epistatic With Shieldin to Limit DNA Double-Strand Break End Resection and Promote Repair During Igh Class Switch Recombination., PMID:40178294
Elevated nonhomologous end-joining by AATF enables efficient DNA damage repair and therapeutic resistance in glioblastoma., PMID:40436899
For research use only. Not for human or drug use.
