Catalog No.
YHK44401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys16-Ile345
Predicted molecular weight
38.95 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9Y496
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Microtubule plus end-directed kinesin motor 3A, Kinesin-like protein KIF3A, KIF3A, KIF3
Note
For research use only.
Kif3a deletion prevents primary cilia assembly on oligodendrocyte progenitor cells, reduces oligodendrogenesis and impairs fine motor function., PMID:33368703
Piccolo is essential for the maintenance of mouse retina but not cochlear hair cell function., PMID:33882456
Restoration of proximal tubule flow-activated transport prevents cyst growth in polycystic kidney disease., PMID:33886508
Heterotrimeric Kinesin II is required for flagellar assembly and elongation of nuclear morphology during spermiogenesis in Schmidtea mediterranea., PMID:34090925
Molecular characterization, dynamic transcription, and potential function of KIF3A/KIF3B during spermiogenesis in Opsariichthys bidens., PMID:34175396
Molecular motor protein KIF5C mediates structural plasticity and long-term memory by constraining local translation., PMID:34260917
Identification of Differentially-Methylated Genes and Pathways in Patients with Delayed Cerebral Ischemia Following Subarachnoid Hemorrhage., PMID:34320780
Histone Deacetylase Sirtuin 1 Promotes Loss of Primary Cilia in Cholangiocarcinoma., PMID:34322899
Photoreceptor Compartment-Specific TULP1 Interactomes., PMID:34360830
Prenatal alcohol exposure disrupts Sonic hedgehog pathway and primary cilia genes in the mouse neural tube., PMID:34492310
Hedgehog-induced ciliary trafficking of kinesin-4 motor KIF7 requires intraflagellar transport but not KIF7's microtubule binding., PMID:34705483
Ift88, but not Kif3a, is required for establishment of the periciliary membrane compartment., PMID:34753064
Skin depletion of Kif3a resembles the pediatric atopic dermatitis transcriptome profile., PMID:34964466
Deletion of kif3a in CK19 positive cells leads to primary cilia loss, biliary cell proliferation and cystic liver lesions in TAA-treated mice., PMID:34973373
Coordination of two kinesin superfamily motor proteins, KIF3A and KIF13A, is essential for pericellular matrix degradation by membrane-type 1 matrix metalloproteinase (MT1-MMP) in cancer cells., PMID:35122963
Hedgehog signaling is controlled by Rac1 activity., PMID:35154488
lncRNA MIR600HG induces the proliferation and invasion of colorectal cancer cells via regulating miR-144-3p/KIF3A., PMID:35378445
Modelling ciliopathy phenotypes in human tissues derived from pluripotent stem cells with genetically ablated cilia., PMID:35478224
The mechanism and effects of remdesivir-induced developmental toxicity in zebrafish: Blood flow dysfunction and behavioral alterations., PMID:35560222
Tumor suppressive role of microRNA-139-5p in bone marrow mesenchymal stem cells-derived extracellular vesicles in bladder cancer through regulation of the KIF3A/p21 axis., PMID:35821021
GFAP-directed Inactivation of Men1 Exploits Glial Cell Plasticity in Favor of Neuroendocrine Reprogramming., PMID:35835391
1-Indanone retards cyst development in ADPKD mouse model by stabilizing tubulin and down-regulating anterograde transport of cilia., PMID:35906293
High-Intensity Focused Ultrasound Induces Adipogenesis via Control of Cilia in Adipose-Derived Stem Cells in Subcutaneous Adipose Tissue., PMID:36012125
Kinesin family member 3A induces related diseases via wingless-related integration site/β-catenin signaling pathway., PMID:36594221
Brain heterotopia formation by ciliopathic breakdown of neuroepithelial and blood-cerebrospinal fluid barriers., PMID:36623505
The ciliary lumen accommodates passive diffusion and vesicle-assisted trafficking in cytoplasm-ciliary transport., PMID:36857170
C. elegans vab-6 encodes a KIF3A kinesin and functions cell non-autonomously to regulate epidermal morphogenesis., PMID:36893881
Ac-SDKP promotes KIF3A-mediated β-catenin suppression through a ciliary mechanism to constrain silica-induced epithelial-myofibroblast transition., PMID:37651800
Inhibitory mechanism of KIF3A gene on nasopharyngeal carcinoma stem cells., PMID:37715417
Primary cilium participates in radiation-induced bystander effects through TGF-β1 signaling., PMID:38009273
Exploration of functional relations among differentially co-expressed genes identifies regulators in glioblastoma., PMID:38335855
KIF3A tail domain phosphorylation is not required for ciliogenesis in mouse embryonic fibroblasts., PMID:38405607
CircRAPGEF5 sponges miR-582-3p and targets KIF3A to regulate bladder cancer cell proliferation, migration and invasion., PMID:38489970
Kinesin KIF3A regulates meiotic progression and spindle assembly in oocyte meiosis., PMID:38587639
Differential DNA methylation associated with delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage: a systematic review., PMID:38594575
Characterization of the disease-causing mechanism of KIF3B mutations from ciliopathy patients., PMID:38665936
Dual and opposing roles for the kinesin-2 motor, KIF17, in Hedgehog-dependent cerebellar development., PMID:38669326
Regulatory role of primary cilia in oral and maxillofacial development and disease., PMID:38714113
Genetic overlap between psoriatic arthritis and ankylosing spondylitis in a Chinese population., PMID:38907550
The heterotrimeric kinesin-2 family member KIF3A directly binds to disabled-1 (Dab1)., PMID:38919020
Cyclin-dependent kinase 4 drives cystic kidney disease in the absence of mTORC1 signaling activity., PMID:39218392
Inhibition of primary cilia-hedgehog signaling axis triggers autophagic cell death and suppresses malignant progression of VHL wild-type ccRCC., PMID:39389955
Gene expression of psychiatric disorder-related kinesin superfamily proteins (Kifs) is potentiated in alternatively activated primary cultured microglia., PMID:39885501
Matricaria chamomilla L. Ameliorates Asthma by Protecting OVA-Induced Rats and LPS-Induced Human Bronchial Epithelial Cells Through Suppressing Autophagy and Apoptosis., PMID:39949885
Cholangiocytes' Primary Cilia Regulate DNA Damage Response and Repair., PMID:39975310
SPOUT1 variants associated with autosomal-recessive developmental and epileptic encephalopathy., PMID:40217412
Disrupted glucocorticoid receptor cell signalling causes a ciliogenesis defect in the fetal mouse renal tubule., PMID:40247090
Alternative spliceosomal protein Eftud2 mediated Kif3a exon skipping promotes SHH-subgroup medulloblastoma progression., PMID:40275081
Loss of primary cilia promotes EphA2-mediated endothelial-to-mesenchymal transition in the ovarian tumor microenvironment., PMID:40397771
Macrophage Accumulation and Cyst Expansion in Pkd2, Ift88, and Double Mutant Mouse Models., PMID:40455584
For research use only. Not for human or drug use.
