Catalog No.
YHE79801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Ala173
Predicted molecular weight
22.12 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P51114
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Fragile X mental retardation syndrome-related protein 1, hFXR1p, FXR1
Note
For research use only.
Fragile X-Related Protein FXR1 Controls Human Adenovirus Capsid mRNA Metabolism., PMID:36749074
Expression of Long Noncoding RNAs in Fibroblasts from Mucopolysaccharidosis Patients., PMID:36833198
RNA-binding protein FXR1 drives cMYC translation by recruiting eIF4F complex to the translation start site., PMID:36884347
The m6A reader PRRC2A is essential for meiosis I completion during spermatogenesis., PMID:36964127
The Fragile X Protein Family in Amyotrophic Lateral Sclerosis., PMID:36991279
FXR1 regulates vascular smooth muscle cell cytoskeleton, VSMC contractility, and blood pressure by multiple mechanisms., PMID:37043351
Genetic Deletion of FXR1 Reduces Intimal Hyperplasia and Induces Senescence in Vascular Smooth Muscle Cells., PMID:37080662
FXR1 impedes the development of osteoarthritis by targeting SND1., PMID:37083155
ARL6IP1 mediates small-molecule-induced alleviation of Alzheimer pathology through FXR1-dependent BACE1 translation initiation., PMID:37216506
Identification of New FG-Repeat Nucleoporins with Amyloid Properties., PMID:37239918
Analysis of various ATP-binding cassette transporters revealed quantification of ABCB4 as a potential diagnostic tool in primary sclerosing cholangitis (PSC)., PMID:37488782
The integration of machine learning and multi-omics analysis provides a powerful approach to screen aging-related genes and predict prognosis and immunotherapy efficacy in hepatocellular carcinoma., PMID:37517087
SARS-CoV-2 hijacks fragile X mental retardation proteins for efficient infection., PMID:37693415
Molecular Mechanisms Involved in MAFLD in Cholecystectomized Patients: A Cohort Study., PMID:37895284
The FXR1 network acts as signaling scaffold for actomyosin remodeling., PMID:37961296
Comprehensive bioinformatics analysis of FXR1 across pan-cancer: Unraveling its diagnostic, prognostic, and immunological significance., PMID:38050239
Wild-type IDH1 maintains NSCLC stemness and chemoresistance through activation of the serine biosynthetic pathway., PMID:38091408
The NSP3 protein of SARS-CoV-2 binds fragile X mental retardation proteins to disrupt UBAP2L interactions., PMID:38177924
Cyfip2 controls the acoustic startle threshold through FMRP, actin polymerization, and GABAB receptor function., PMID:38187577
The multifaceted role of Fragile X-Related Protein 1 (FXR1) in cellular processes: an updated review on cancer and clinical applications., PMID:38238286
MicroRNA-320a enhances LRWD1 expression through the AGO2/FXR1-dependent pathway to affect cell behaviors and the oxidative stress response in human testicular embryonic carcinoma cells., PMID:38385979
FXR1 stabilizes SNORD63 to regulate blood-tumor barrier permeability through SNORD63 mediated 2'-O-methylation of POU6F1., PMID:38460644
METTL3 and METTL14-mediated N6-methyladenosine modification of SREBF2-AS1 facilitates hepatocellular carcinoma progression and sorafenib resistance through DNA demethylation of SREBF2., PMID:38486042
LLPS of FXR proteins drives replication organelle clustering for β-coronaviral proliferation., PMID:38587486
UBAP2L ensures homeostasis of nuclear pore complexes at the intact nuclear envelope., PMID:38652117
PRMT5-mediated arginine methylation of FXR1 is essential for RNA binding in cancer cells., PMID:38709899
Disruption of G3BP1 Granules Promotes Mammalian CNS and PNS Axon Regeneration., PMID:38895344
Modulatory Roles of AHR, FFAR2, FXR, and TGR5 Gene Expression in Metabolic-Associated Fatty Liver Disease and COVID-19 Outcomes., PMID:38932276
Regulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesis., PMID:38937540
The FXR1 network acts as a signaling scaffold for actomyosin remodeling., PMID:39106863
An in-depth review of the function of RNA-binding protein FXR1 in neurodevelopment., PMID:39155323
Epithelioid Fibrous Histiocytoma Is on a Continuum With Superficial ALK -rearranged Myxoid Spindle Cell Neoplasm : A Clinicopathologic Series of 35 Cases Including Alternate RET and NTRK3 Fusions., PMID:39329254
Targeting KIFC1 Promotes Senescence in Soft Tissue Sarcoma via FXR1-Dependent Regulation of MAD2L1 mRNA Stability., PMID:39387242
Elucidating the roles of SOD3 correlated genes and reactive oxygen species in rare human diseases using a bioinformatic-ontology approach., PMID:39480826
The Spatial-Temporal Alternative Splicing Profile Reveals the Functional Diversity of FXR1 Isoforms in Myogenesis., PMID:39499773
FXR1 associates with and degrades PDZK1IP1 and ATOH8 mRNAs and promotes esophageal cancer progression., PMID:39511680
Alternative splicing is an FXRα loss-of-function mechanism and impacts energy metabolism in hepatocarcinoma cells., PMID:39608717
CircZMYM2 plays a pivotal role in osteosarcoma by regulating the translation of NACA and ARPC1B., PMID:39624324
Capsaicin and Quercitrin Maintained Lipid Homeostasis of Hyperlipidemic Mice: Serum Metabolomics and Signaling Pathways., PMID:39682799
Fxr1 Deletion from Cortical Parvalbumin Interneurons Modifies Their Excitatory Synaptic Responses., PMID:39753370
Ferroptosis Transcriptional Regulation and Prognostic Impact in Medulloblastoma Subtypes Revealed by RNA-Seq., PMID:39857430
IGF2BP1 stabilizes Akt2 mRNA to promote glucose metabolism and maintain spermatogonial proliferation., PMID:39902819
Disruption of G3BP1 granules promotes mammalian CNS and PNS axon regeneration., PMID:40014573
The prognostic significance of fragile X mental retardation syndrome-related protein 1 (FXR1) in breast cancer., PMID:40104750
Clinical Significance of Fragile X Syndrome 2 (FXR2) in Breast Cancer., PMID:40149453
Estrogen-induced FXR1 promotes endocrine resistance and bone metastasis in breast cancer via BCL2 and GPX4., PMID:40196843
Dendrobium huoshanense polysaccharide inhibits NSCLC proliferation and immune evasion via FXR1-IL-35 axis signaling pathway., PMID:40259042
m6A-modified MIR670HG suppresses tumor liver metastasis through enhancing Kupffer cell phagocytosis., PMID:40293529
Muscle-specific isoforms of FXR1 are necessary for miR-1-mediated repression of connexin 43 and are downregulated in pediatric dilated cardiomyopathy., PMID:40323739
Functional amyloid protein FXR1 is recruited into neuronal stress granules., PMID:40411539
For research use only. Not for human or drug use.
