Catalog No.
YHB26701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg94-Glu256
Predicted molecular weight
20.54 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75616
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Conserved ERA-like GTPase, HERA, GTPase Era, mitochondrial, ERA-like protein 1, H-ERA, ERAL1, hERA, ERA-W, CEGA
Note
For research use only.
Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene era., PMID:10945472
ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation., PMID:20430825
Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit., PMID:20604745
The role of TFAM-associated proteins in mitochondrial RNA metabolism., PMID:21920408
Autophagy is induced through the ROS-TP53-DRAM1 pathway in response to mitochondrial protein synthesis inhibition., PMID:22576012
CLPP coordinates mitoribosomal assembly through the regulation of ERAL1 levels., PMID:27797820
Mitochondrial nucleic acid binding proteins associated with diseases., PMID:27814609
A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome., PMID:28449065
Global Proteome of LonP1+/- Mouse Embryonal Fibroblasts Reveals Impact on Respiratory Chain, but No Interdependence between Eral1 and Mitoribosomes., PMID:31547314
LARS2-Perrault syndrome: a new case report and literature review., PMID:32423379
RCC1L (WBSCR16) isoforms coordinate mitochondrial ribosome assembly through their interaction with GTPases., PMID:32735630
The mitochondrial protein ERAL1 suppresses RNA virus infection by facilitating RIG-I-like receptor signaling., PMID:33472079
Quantitative Proteomics Analysis of Berberine-Treated Colon Cancer Cells Reveals Potential Therapy Targets., PMID:33806918
YbeY, éminence grise of ribosome biogenesis., PMID:33929506
New insights into Perrault syndrome, a clinically and genetically heterogeneous disorder., PMID:34338890
Genetics of ovarian insufficiency and defects of folliculogenesis., PMID:34794894
Inactivity of Peptidase ClpP Causes Primary Accumulation of Mitochondrial Disaggregase ClpX with Its Interacting Nucleoid Proteins, and of mtDNA., PMID:34943861
Exploring the Genetic Association between Obesity and Serum Lipid Levels Using Bivariate Methods., PMID:36606461
CLPP Depletion Causes Diplotene Arrest; Underlying Testis Mitochondrial Dysfunction Occurs with Accumulation of Perrault Proteins ERAL1, PEO1, and HARS2., PMID:36611846
Ataxia and Hypogonadism: a Review of the Associated Genes and Syndromes., PMID:36997834
GTPase Era at the heart of ribosome assembly., PMID:37860580
Axonal polyneuropathy and ataxia in children: consider Perrault Syndrome, a case report., PMID:37932750
Translation Fidelity and Respiration Deficits in CLPP-Deficient Tissues: Mechanistic Insights from Mitochondrial Complexome Profiling., PMID:38139332
Intra-tumoral delivery of 5'ppp-dsRNA induces a robust antitumor response via RIG-I activation and Bcl-2 gene downregulation in a murine model of prostate cancer., PMID:39387130
Mendelian randomization provides a multi-omics perspective on the regulation of genes involved in ribosome biogenesis in relation to cardiac structure and function., PMID:40045424
For research use only. Not for human or drug use.
