Catalog No.
YHK44101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys151-Pro560
Predicted molecular weight
48.28 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99741
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
HsCdc18, CDC18L, CDC6, HsCDC6, CDC6-related protein, Cell division control protein 6 homolog, p62(cdc6), Cdc18-related protein
Note
For research use only.
Identification and characterisation of a novel EhOrc1/Cdc6 from the human pathogen Entamoeba histolytica: an in silico approach., PMID:38095553
Requirement of Site-Specific Tyrosine Phosphorylation of Cortactin in Retinal Neovascularization and Vascular Leakage., PMID:38126170
PSMA7 promotes the malignant proliferation of esophageal cancer., PMID:38173490
CDC6 may serve as an indicator of lung adenocarcinoma prognosis and progression based on TCGA and GEO data mining and experimental analyses., PMID:38186304
The N-terminal region of Cdc6 specifically recognizes human DNA G-quadruplex., PMID:38237821
Prognosis and immunotherapy significances of a cancer-associated fibroblasts-related gene signature in lung adenocarcinoma., PMID:38279482
Identification of CDKN3 as a Key Gene that Regulates Neuroblastoma Cell Differentiation., PMID:38356706
Cooperation between two modes for DNA replication initiation in the archaeon Thermococcus barophilus., PMID:38421162
CUL4A Ubiquitin Ligase Is an Independent Predictor of Overall Survival in Pancreatic Adenocarcinoma., PMID:38423594
miR-26a-5p inhibits the proliferation of psoriasis-like keratinocytes in vitro and in vivo by dual interference with the CDC6/CCNE1 axis., PMID:38446584
Screening and verification of hub genes in esophageal squamous cell carcinoma by integrated analysis., PMID:38519533
Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance., PMID:38685067
Nobiletin Inhibits Breast Cancer Stem Cell by Regulating the Cell Cycle: A Comprehensive Bioinformatics Analysis and In Vitro Experiments., PMID:38721626
Restricting the level of the proteins essential for the regulation of the initiation step of replication extends the chronological lifespan and reproductive potential in budding yeast., PMID:38844751
Mck1-mediated proteolysis of CENP-A prevents mislocalization of CENP-A for chromosomal stability in Saccharomyces cerevisiae., PMID:38984710
Cdt1 Self-associates via the Winged-Helix Domain of the Central Region during the Licensing Reaction, Which Is Inhibited by Geminin., PMID:39048355
Comprehensive analysis of aberrantly methylated differentially expressed genes and validation of CDC6 in melanoma., PMID:39052109
Unveiling the functions of five recently characterized lncRNAs in cancer progression., PMID:39066874
Dual Inhibition of SYK and EGFR Overcomes Chemoresistance by Inhibiting CDC6 and Blocking DNA Replication., PMID:39120597
Combination of AID2 and BromoTag expands the utility of degron-based protein knockdowns., PMID:39179892
A high-throughput screening identifies MCM chromatin loading inhibitors targeting cells with increased replication origins., PMID:39184446
Replication licensing regulated by a short linear motif within an intrinsically disordered region of origin recognition complex., PMID:39271725
Construction of a novel model based on PVT1-MYC duet-related genes for predicting survival and characterization of the tumor microenvironment in pancreatic cancer., PMID:39376555
Integrated network pharmacology and transcriptomic approach reveal the role of equol in reducing colorectal cancer via regulating multiple cell cycle genes in HCT116 cells., PMID:39461627
New insight into the development of synpolydactyly caused by expansion of HOXD13 polyalanine based on weighted gene co-expression network analysis., PMID:39472920
Unraveling the genetic basis of azoospermia: transcriptome profiling analyses in a Greek population., PMID:39515755
SKP2 inhibition activates tumor cell-intrinsic immunity by inducing DNA replication stress and genomic instability., PMID:39582087
Multiple mechanisms for licensing human replication origins., PMID:39604729
MCM double hexamer loading visualized with human proteins., PMID:39604733
Cell division cycle 6 is an independent prognostic biomarker in breast cancer., PMID:39668074
Exploring Bioinformatics Tools to Analyze the Role of CDC6 in the Progression of Polycystic Ovary Syndrome to Endometrial Cancer by Promoting Immune Infiltration., PMID:39684684
Transcriptional analysis reveals the suppression of RAD51 and disruption of the homologous recombination pathway during PEDV infection in IPEC-J2 cells., PMID:39731192
MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis., PMID:39747125
RNA Sequencing and Weighted Gene Co-Expression Network Analysis Highlight DNA Replication and Key Genes in Nucleolin-Depleted Hepatoblastoma Cells., PMID:39766782
The bioinformatics analysis and experimental validation of the carcinogenic role of EXO1 in lung adenocarcinoma., PMID:39777332
Reconstitution of human DNA licensing and the structural and functional analysis of key intermediates., PMID:39779677
Unidirectional MCM translocation away from ORC drives origin licensing., PMID:39824870
Downregulated TFPI2 Accelerates Skin Aging by Repressing the Cell Cycle through Phosphoinositide 3-Kinase/Protein Kinase B/CDC6 Pathway., PMID:39848565
Biomarker Panels Associated with Diagnosis and Overall Survival in Hepatocellular Carcinoma Revealed from Protein-Protein and mRNA-miRNA Interaction Networks., PMID:39874008
Comprehensive multi-omics analysis showed that CDC6 is a potential prognostic and immunotherapy biomarker for multiple cancer types including HCC., PMID:39904279
Unraveling the molecular landscape of non-small cell lung cancer: Integrating bioinformatics and statistical approaches to identify biomarkers and drug repurposing., PMID:39914199
Utility of a Large Series of B-Cell Precursor Acute Lymphoblastic Leukemia Cell Lines as a Model System., PMID:40022573
Ginsenoside Rg5 inhibits the proliferation of HeLa cell through cell cycle pathway., PMID:40196332
Immunohistochemistry and machine learning study of DNA replication-associated proteins in uterine epithelial tumors and precursor lesions., PMID:40220589
20(S)-ginsenoside Rg3 suppresses gastric cancer cell proliferation by inhibiting E2F-DP dimerization., PMID:40252583
CDC6 as early biomarker for myocardial infarction with acute cellular senescence and repair mechanisms., PMID:40269003
DNA replication in primary hepatocytes without the six-subunit ORC., PMID:40304571
CDC6 Inhibits CDK1 Activity in MII-Arrested Oocyte Cell-Free Extract., PMID:40362544
Clofarabine Enhances the Transduction Efficiency of Recombinant AAV2 in the Retina., PMID:40434346
BRCA2 reversion mutation-independent resistance to PARP inhibition through impaired DNA prereplication complex function., PMID:40460119
For research use only. Not for human or drug use.
