Catalog No.
YHE17601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Lys182
Predicted molecular weight
22.62 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P36405
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ARFL3, ADP-ribosylation factor-like protein 3, ARL3
Note
For research use only.
Dominant ARL3-related retinitis pigmentosa., PMID:30932721
The ciliary GTPase Arl3 maintains tissue architecture by directing planar spindle orientation during epidermal morphogenesis., PMID:30952667
ARL3 is downregulated and acts as a prognostic biomarker in glioma., PMID:31234870
The golgin PpImh1 mediates reversible cisternal stacking in the Golgi of the budding yeast Pichia pastoris., PMID:31391238
Homozygous Variant in ARL3 Causes Autosomal Recessive Cone Rod Dystrophy., PMID:31743939
Diffuse or hitch a ride: how photoreceptor lipidated proteins get from here to there., PMID:31811799
ARL3, a small GTPase with a functionally conserved role in primary cilia and immune synapses., PMID:31826708
Evaluation of the relationships of the WBP1L gene with schizophrenia and the general psychopathology scale based on a case-control study., PMID:31840934
The Dynamic and Complex Role of the Joubert Syndrome-Associated Ciliary Protein, ADP-Ribosylation Factor-Like GTPase 13B (ARL13B) in Photoreceptor Development and Maintenance., PMID:31884661
ARL13B regulates Sonic hedgehog signaling from outside primary cilia., PMID:32129762
ARF family GTPases with links to cilia., PMID:32520609
Flagellar targeting of an arginine kinase requires a conserved lipidated protein intraflagellar transport (LIFT) pathway in Trypanosoma brucei., PMID:32587088
Expression patterns of ciliopathy genes ARL3 and CEP120 reveal roles in multisystem development., PMID:33297941
N6 -methyladenosine modification of circular RNA circ-ARL3 facilitates Hepatitis B virus-associated hepatocellular carcinoma via sponging miR-1305., PMID:33372396
ARL3 activation requires the co-GEF BART and effector-mediated turnover., PMID:33438581
Autosomal Recessive Rod-Cone Dystrophy Associated With Compound Heterozygous Variants in ARL3 Gene., PMID:33748123
The Structural and Biochemical Characterization of UNC119B Cargo Binding and Release Mechanisms., PMID:34130453
Genetic compensation for cilia defects in cep290 mutants by upregulation of cilia-associated small GTPases., PMID:34155518
Mechanism of Guanosine Triphosphate Hydrolysis by the Visual Proteins Arl3-RP2: Free Energy Reaction Profiles Computed with Ab Initio Type QM/MM Potentials., PMID:34208932
Transcript pattern analysis of Arf-family genes in the phytopathogen Fusarium oxysporum f. sp. lycopersici reveals the role of Arl3 in the virulence., PMID:34338933
ARL3 and ARL13B GTPases participate in distinct steps of INPP5E targeting to the ciliary membrane., PMID:34447983
The ARF GAPs ELMOD1 and ELMOD3 act at the Golgi and cilia to regulate ciliogenesis and ciliary protein traffic., PMID:34818063
Autophagy promotes hepatic cystogenesis in polycystic liver disease by depletion of cholangiocyte ciliogenic proteins., PMID:34942041
Tracheal tube fusion in Drosophila involves release of extracellular vesicles from multivesicular bodies., PMID:35019140
Phylogenetic profiling and cellular analyses of ARL16 reveal roles in traffic of IFT140 and INPP5E., PMID:35196065
Retinitis pigmentosa 2 pathogenic mutants degrade through BAG6/HUWE1 complex., PMID:35569519
Primary cilia in satellite cells are the mechanical sensors for muscle hypertrophy., PMID:35671424
Ciliary Proteins Repurposed by the Synaptic Ribbon: Trafficking Myristoylated Proteins at Rod Photoreceptor Synapses., PMID:35806143
PFN4 is required for manchette development and acrosome biogenesis during mouse spermiogenesis., PMID:35950913
ARL3 mediates BBSome ciliary turnover by promoting its outward movement across the transition zone., PMID:36129685
The Deubiquitinating Enzyme USP48 Interacts with the Retinal Degeneration-Associated Proteins UNC119a and ARL3., PMID:36293380
Visualizing Reversible Cisternal Stacking in Budding Yeast Pichia pastoris., PMID:36512232
Mendelian Randomization Study Using Dopaminergic Neuron-Specific eQTL Identifies Novel Risk Genes for Schizophrenia., PMID:36517655
Investigation the global effect of rare earth gadolinium on the budding Saccharomyces cerevisiae by genome-scale screening., PMID:36519157
Disrupting the ciliary gradient of active Arl3 affects rod photoreceptor nuclear migration., PMID:36598133
A stress-induced cilium-to-PML-NB route drives senescence initiation., PMID:37019904
The challenge of dissecting gene function in model organisms: Tools to characterize genetic mutants and assess transcriptional adaptation in zebrafish., PMID:37164532
Ciliary ARL13B inhibits developmental kidney cystogenesis in mouse., PMID:37209936
Human Mutations in Arl3, a Small GTPase Involved in Lipidated Cargo Delivery to the Cilia, Cause Retinal Dystrophy., PMID:37440046
RABL2 promotes the outward transition zone passage of signaling proteins in cilia via ARL3., PMID:37579161
Combining a prioritization strategy and functional studies nominates 5'UTR variants underlying inherited retinal disease., PMID:38184646
Mechanisms underlying morphological and functional changes of cilia in fibroblasts derived from patients bearing ARL3T31A and ARL3T31A/C118F mutations., PMID:38457249
BAG3 regulates cilia homeostasis of glioblastoma via its WW domain., PMID:38655699
Piperine inhibits the proliferation of colorectal adenocarcinoma by regulating ARL3-mediated endoplasmic reticulum stress., PMID:38972051
ARL3 GTPases facilitate ODA16 unloading from IFT in motile cilia., PMID:39231220
Mitochondrial functional impairment in ARL3-mutation related rod-cone dystrophy., PMID:39512837
Integrative in silico and biochemical analyses demonstrate direct Arl3-mediated ODA16 release from the intraflagellar transport machinery., PMID:39880089
A novel recurrent ARL3 variant c.209G > A p.(Gly70Glu) causes variable non-syndromic dominant retinal dystrophy with defective lipidated protein transport in human retinal stem cell models., PMID:40037334
Intra-Golgi Golgin PpSgm1 and GRIP domain Golgin PpImh1 synergistically mediate Golgi cisternal stacking., PMID:40270185
For research use only. Not for human or drug use.
