Catalog No.
YHK43501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser54-Glu445
Predicted molecular weight
44.76 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9P2R7
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ATP-specific succinyl-CoA synthetase subunit beta, SCS-betaA, Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial, A-SCS, Succinyl-CoA synthetase beta-A chain, SUCLA2
Note
For research use only.
Influences of XDH genotype by gene-gene interactions with SUCLA2 for thiopurine-induced leukopenia in Korean patients with Crohn's disease., PMID:26863601
Novel mutation in SUCLA2 identified on sequencing analysis., PMID:26952923
A Balanced Tissue Composition Reveals New Metabolic and Gene Expression Markers in Prostate Cancer., PMID:27100877
[Clinical and laboratory studies on four Chinese patients with succinate-CoA ligase deficiency noticed by mild methylmalonic aciduria]., PMID:27143079
Expanding the phenotypic spectrum of Succinyl-CoA ligase deficiency through functional validation of a new SUCLG1 variant., PMID:27484306
Two transgenic mouse models for β-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations., PMID:27496549
A Novel SUCLA2 Mutation Presenting as a Complex Childhood Movement Disorder., PMID:27651038
Knockdown of Sucla2 decreases the viability of mouse spermatocytes by inducing apoptosis through injury of the mitochondrial function of cells., PMID:27766610
Succinyl-CoA synthetase (SUCLA2) deficiency in two siblings with impaired activity of other mitochondrial oxidative enzymes in skeletal muscle without mitochondrial DNA depletion., PMID:27913098
Mitochondrial DNA maintenance defects., PMID:28215579
NF-κB controls four genes encoding core enzymes of tricarboxylic acid cycle., PMID:28400269
Co-occurring Down syndrome and SUCLA2-related mitochondrial depletion syndrome., PMID:28749033
Clinical, Molecular, and Computational Analysis in two cases with mitochondrial encephalomyopathy associated with SUCLG1 mutation in a consanguineous family., PMID:29217198
[Heterogeneous phenotypes, genotypes, treatment and prevention of 1 003 patients with methylmalonic acidemia in the mainland of China]., PMID:29886603
Improving the diagnosis of cobalamin and related defects by genomic analysis, plus functional and structural assessment of novel variants., PMID:30041674
Mutated SUCLG1 causes mislocalization of SUCLG2 protein, morphological alterations of mitochondria and an early-onset severe neurometabolic disorder., PMID:30470562
[Phenotype and genotype of twelve Chinese children with mitochondrial DNA depletion syndromes]., PMID:30818899
Proteome of cat semen obtained after urethral catheterization., PMID:31518731
Qishen granules exerts cardioprotective effects on rats with heart failure via regulating fatty acid and glucose metabolism., PMID:32158496
Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15 variants., PMID:32221476
Identification of lipid raft glycoproteins obtained from boar spermatozoa., PMID:32367480
Lower oxygen consumption and Complex I activity in mitochondria isolated from skeletal muscle of fetal sheep with intrauterine growth restriction., PMID:32396498
Genomic characterization and prognostication applied to a Brazilian cohort of patients with myelofibrosis., PMID:32535855
Pharmacologically targetable vulnerability in prostate cancer carrying RB1-SUCLA2 deletion., PMID:32694611
Arachidyl amido cholanoic acid improves liver glucose and lipid homeostasis in nonalcoholic steatohepatitis via AMPK and mTOR regulation., PMID:32982112
SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease., PMID:33230181
SUCLG1 mutations and mitochondrial encephalomyopathy: a case study and review of the literature., PMID:33230783
SUCLA2 Arg407Trp mutation can cause a nonprogressive movement disorder - deafness syndrome., PMID:33231368
Glycolysis-Related Genes Serve as Potential Prognostic Biomarkers in Clear Cell Renal Cell Carcinoma., PMID:33564363
SUCLA2-coupled regulation of GLS succinylation and activity counteracts oxidative stress in tumor cells., PMID:33991485
Altered skeletal muscle metabolic pathways, age, systemic inflammation, and low cardiorespiratory fitness associate with improvements in disease activity following high-intensity interval training in persons with rheumatoid arthritis., PMID:34246305
Long Noncoding RNA LOC554202 Predicts a Poor Prognosis and Correlates with Immune Infiltration in Thyroid Cancer., PMID:35265169
Comparative high-throughput analysis of sperm membrane proteins from crossbred bulls with contrasting fertility., PMID:35484731
Proteomic analysis of the heart in normal aging mice., PMID:36244772
Protein succinylation associated with the progress of hepatocellular carcinoma., PMID:36308411
The impact of RNA binding proteins and the associated long non-coding RNAs in the TCA cycle on cancer pathogenesis., PMID:37221841
Succinyl-CoA ligase ADP-forming subunit beta promotes stress granule assembly to regulate redox and drive cancer metastasis., PMID:37253003
Identification of genes related to glucose metabolism and analysis of the immune characteristics in Alzheimer's disease., PMID:37619853
Loss of succinyl-CoA synthetase in mouse forebrain results in hypersuccinylation with perturbed neuronal transcription and metabolism., PMID:37819759
Transcriptomics and metabolomics study in mouse kidney of the molecular mechanism underlying energy metabolism response to hypoxic stress in highland areas., PMID:37869643
Significance and Possible Biological Mechanism for CLDN8 Downregulation in Kidney Renal Clear Cell Carcinoma Tissues., PMID:38993257
Host genetics and gut microbiota synergistically regulate feed utilization in egg-type chickens., PMID:39245742
Sucla2 Knock-Out in Skeletal Muscle Yields Mouse Model of Mitochondrial Myopathy With Muscle Type-Specific Phenotypes., PMID:39482887
Impact of missense mutations on the structure-function relationship of human succinyl-CoA synthetase using in silico analysis., PMID:39500468
Reverse phase protein array-based investigation of mitochondrial genes reveals alteration of glutaminolysis in the parahippocampal cortex of people who died by suicide., PMID:39604371
SIRT5 mediated succinylation of SUCLA2 regulates TCA cycle dysfunction and mitochondrial damage in pancreatic acinar cells in acute pancreatitis., PMID:39643219
OXCT1 succinylation and activation by SUCLA2 promotes ketolysis and liver tumor growth., PMID:39862868
Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK., PMID:39966410
Investigating the safety and efficacy of deoxycytidine/deoxythymidine in mitochondrial DNA depletion disorders: phase 2 open-label trial., PMID:40175578
Exploring the Interconnections Between Mitochondrial Dysfunction and Polycystic Ovary Syndrome: A Comprehensive Integrated Analysis., PMID:40259200
For research use only. Not for human or drug use.
