Catalog No.
YHA07501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Pro75-Asp195
Predicted molecular weight
16.02 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00264
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PGRMC, mPR, IZA, Membrane-associated progesterone receptor component 1, HPR6.6, Dap1, PGRMC1
Note
For research use only.
Hepatic progesterone receptor membrane component 1 attenuates ethanol-induced liver injury by reducing acetaldehyde production and oxidative stress., PMID:37070746
Molecular insights underlying the adverse effects of bisphenol A on gonadal somatic cells' steroidogenic activity., PMID:37084542
Insight into mitochondrial dysfunction mediated by clozapine-induced inhibition of PGRMC1 in PC12 cells., PMID:37087062
Heme induced progesterone-resistant profiling and promotion of endometriosis in vitro and in vivo., PMID:37247698
In vitro chemo-preventive efficacy of synthetic progestin Norethindrone in human epithelial ovarian cancer., PMID:37270458
Expression of PGRMC1 in patients with polycystic ovary syndrome and its molecular mechanism for regulating ovarian granulosa cell apoptosis and glucolipid metabolism., PMID:37385616
Membrane-bound progesterone receptors in the canine uterus and placenta; possible targets in the maintenance of pregnancy., PMID:37480804
Effects of estradiol, progesterone or cAMP on expression of PGRMC1 and progesterone receptor in a xenograft model of human endometrium and in endometrial cell culture., PMID:37487815
Clinical Importance of PGRMC1 in Hormone Responsive Breast Cancer., PMID:37529370
Genetically incorporated crosslinkers identify regulators of membrane protein PD-L1 in mammalian cells., PMID:37541256
The Involvement of PGRMC1 Signaling in Cognitive Impairment Induced by Long-Term Clozapine Treatment in Rats., PMID:37673050
Prenatal Arsenite Exposure Alters Maternal Cardiac Remodeling During Late Pregnancy., PMID:37808684
Sigma Receptors: Novel Regulators of Iron/Heme Homeostasis and Ferroptosis., PMID:37834119
Progesterone receptor membrane component 1 facilitates Ca2+ signal amplification between endosomes and the endoplasmic reticulum., PMID:37866635
Navigating a plethora of progesterone receptors: Comments on the safety/risk of progesterone supplementation in women with a history of breast cancer or at high-risk for developing breast cancer., PMID:37884178
Progesterone Receptor Membrane Component 1 (PGRMC1) Modulates Tumour Progression, the Immune Microenvironment and the Response to Therapy in Glioblastoma., PMID:37887342
New Insights on the Progesterone (P4) and PGRMC1/NENF Complex Interactions in Colorectal Cancer Progression., PMID:37894441
Downregulation of PGRMC1 accelerates differentiation and fusion of a human trophoblast cell line., PMID:37965940
Regulatory action of PGRMC1 on cyclic AMP-mediated COX2 expression in human endometrial cells., PMID:37973216
A Systems Biology Approach for Investigating Significant Biomarkers and Drug Targets Common Among Patients with Gonorrhea, Chlamydia, and Prostate Cancer: A Pilot Study., PMID:38033384
Identification of postnatal development dependent genes and proteins in porcine epididymis., PMID:38049726
Prenatal arsenite exposure alters maternal cardiac remodeling during late pregnancy., PMID:38266874
Identification of DNA methylation biomarkers for evaluating cardiovascular disease risk from epigenome profiles altered by low-dose ionizing radiation., PMID:38303056
Progesterone-induced progesterone receptor membrane component 1 rise-to-decline changes are essential for decidualization., PMID:38308254
Altered luteal expression patterns of genomic and non-genomic progesterone receptors in bitches at different reproductive states., PMID:38325152
B-GOS alleviates olanzapine-induced lipid disturbances in mice by enriching Akkermansia and upregulation of PGRMC1-Wnt signaling., PMID:38325638
Deciphering the role of PGRMC2 in the human endometrium during the menstrual cycle and in vitro decidualization using an in vitro approach., PMID:38452349
Defining Requirements for Heme Binding in PGRMC1 and Identifying Key Elements that Influence Protein Dimerization., PMID:38489495
Preclinical Targeting of the PGRMC1-CK2 Axis with Silmitasertib: A Potential Strategy for Lung Adenocarcinoma Therapy., PMID:38508228
Beyond Hormones: Investigating the Impact of Progesterone Receptor Membrane Component 1 in Lung Adenocarcinoma., PMID:38546883
Progesterone-mediated remodeling of the maternal-fetal interface by a PGRMC1-dependent mechanism., PMID:38555747
Association between parity and pregnancy-associated tumor features in high-grade serous ovarian cancer., PMID:38578428
Pleiotropy of Progesterone Receptor Membrane Component 1 in Modulation of Cytochrome P450 Activity., PMID:38804287
RTN3L and CALCOCO1 function in parallel to maintain proteostasis in the endoplasmic reticulum., PMID:38818751
A Novel Receptor Binding Progesterone, a Possible Transregulation Mechanism in the Rhipicephalus microplus-Host Interaction., PMID:38940045
Translocation of Adenosine A2B Receptor to Mitochondria Influences Cytochrome P450 2E1 Activity after Acetaminophen Overdose., PMID:39007013
Cytochrome P450 2J2 is required for the natural compound austocystin D to elicit cancer cell toxicity., PMID:39009033
PGRMC1 promotes NSCLC stemness phenotypes by disrupting TRIM56-mediated ubiquitination of AHR., PMID:39059592
Proteomic Profile of Endometrial Cancer: A Scoping Review., PMID:39194522
Progesterone and estradiol alleviate Poly I:C-induced immune response in endometrial stromal cells., PMID:39241576
High concentrations of progesterone inhibit the expression of genes related to steroid metabolism in MA-10 Leydig cells., PMID:39307342
Exploring the effects of pemetrexed on drug resistance mechanisms in human lung adenocarcinoma and its association with PGRMC1., PMID:39368770
Construction and multiple validations of a robust ferroptosis-related prognostic model in bladder cancer: A comprehensive study., PMID:39432593
Liver-specific gene PGRMC1 blocks c-Myc-induced hepatocarcinogenesis through ER stress-independent PERK activation., PMID:39747098
[Roles of Trophoblast Differentiation, Cell Fusion, and Microvilli Formation in Placentation and Prospects for a Model for Their Assessment]., PMID:39756925
Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence., PMID:39804138
Protein subinteractomes of human microsomal cytochromes P450., PMID:39937310
Do progesterone receptor membrane components (PGRMC)s play a role in the chorions refractoriness to epithelial-to-mesenchymal transition (EMT)?, PMID:39999661
The surface proteome of rabbit spermatozoa., PMID:40199101
Identification of FDFT1 and PGRMC1 as New Biomarkers in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocellular Carcinoma by Deep Learning., PMID:40206734
For research use only. Not for human or drug use.
