Recombinant Human LMOD3 Protein, N-His

Catalog No.

YHG23501

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Asn237-Gln409

Predicted molecular weight

22.43 kDa

Nature

Recombinant

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

Q0VAK6

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

LMOD3, Leiomodin-3, Leiomodin, fetal form

Note

For research use only.

Leiomodin 1, a new serum response factor-dependent target gene expressed preferentially in differentiated smooth muscle cells., PMID:22157009

KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy., PMID:24960163

Global MEF2 target gene analysis in cardiac and skeletal muscle reveals novel regulation of DUSP6 by p38MAPK-MEF2 signaling., PMID:25217591

Leiomodin-3 dysfunction results in thin filament disorganization and nemaline myopathy., PMID:25250574

Leiomodin 3 and tropomodulin 4 have overlapping functions during skeletal myofibrillogenesis., PMID:25431137

Severe myopathy in mice lacking the MEF2/SRF-dependent gene leiomodin-3., PMID:25774500

Leiomodin-3-deficient mice display nemaline myopathy with fast-myofiber atrophy., PMID:26035871

LMOD3: the "missing link" in nemaline myopathy?, PMID:26337340

Tropomodulin 1 directly controls thin filament length in both wild-type and tropomodulin 4-deficient skeletal muscle., PMID:26586224

Lmod2 piggyBac mutant mice exhibit dilated cardiomyopathy., PMID:27274810

Regulation of Hspb7 by MEF2 and AP-1: implications for Hspb7 in muscle atrophy., PMID:27632998

Efficient induction of inner ear hair cell-like cells from mouse ES cells using combination of Math1 transfection and conditioned medium from ST2 stromal cells., PMID:28689068

Neonatal fractures as a presenting feature of LMOD3-associated congenital myopathy., PMID:28815944

LMOD3-Associated Nemaline Myopathy: Prenatal Ultrasonographic, Pathologic, and Molecular Findings., PMID:29331079

Kleine-Levin syndrome is associated with LMOD3 variants., PMID:29923248

Evidence of mild founder LMOD3 mutations causing nemaline myopathy 10 in Germany and Austria., PMID:30291184

Long-term follow-up and characteristic pathological findings in severe nemaline myopathy due to LMOD3 mutations., PMID:30642739

Nemaline myopathies: a current view., PMID:31228046

Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy., PMID:31517052

Compound Heterozygosity for Novel Truncating Variants in the LMOD3 Gene as the Cause of Polyhydramnios in Two Successive Fetuses., PMID:31572445

Association of fingerprint bodies with rods in a case with mutations in the LMOD3 gene., PMID:32008911

Lmod3 promotes myoblast differentiation and proliferation via the AKT and ERK pathways., PMID:32980291

Phenotypic spectrum and genomics of undiagnosed arthrogryposis multiplex congenita., PMID:33820833

Genetic dissection of novel myopathy models reveals a role of CapZα and Leiomodin 3 during myofibril elongation., PMID:35148320

Comparative proteomics reveals genetic mechanisms of body weight in Hu sheep and Dorper sheep., PMID:35995385

Decreased Levels of DNA Methylation in the PCDHA Gene Cluster as a Risk Factor for Early-Onset High Myopia in Young Children., PMID:36036911

Sleep Disorder Kleine-Levin Syndrome (KLS) Joins the List of Polygenic Brain Disorders Associated with Obstetric Complications., PMID:37553546

A nemaline myopathy-linked mutation inhibits the actin-regulatory functions of tropomodulin and leiomodin., PMID:37956287

Integration of ATAC-Seq and RNA-Seq Analysis to Identify Key Genes in the Longissimus Dorsi Muscle Development of the Tianzhu White Yak., PMID:38203329

Lmod2 is necessary for effective skeletal muscle contraction., PMID:38478604

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