Catalog No.
YHK43001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp716-Phe1008
Predicted molecular weight
36.30 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NSV4
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein diaphanous homolog 3, DRF3, DIAPH3, DIAP3, Diaphanous-related formin-3, MDia2
Note
For research use only.
mDia2 and CXCL12/CXCR4 chemokine signaling intersect to drive tumor cell amoeboid morphological transitions., PMID:28115158
Diaphanous-related formin-3 overexpression inhibits the migration and invasion of triple-negative breast cancer by inhibiting RhoA-GTP expression., PMID:28779705
DIAPH3 promoted the growth, migration and metastasis of hepatocellular carcinoma cells by activating beta-catenin/TCF signaling., PMID:28795316
Cytokinesis requires localized β-actin filament production by an actin isoform specific nucleator., PMID:29146911
Carcinoma associated fibroblasts (CAFs) promote breast cancer motility by suppressing mammalian Diaphanous-related formin-2 (mDia2)., PMID:29596520
Formin-dependent TGF-β signaling for epithelial to mesenchymal transition., PMID:29668357
Emerin Deregulation Links Nuclear Shape Instability to Metastatic Potential., PMID:30154147
DIAPH2 alterations increase cellular motility and may contribute to the metastatic potential of laryngeal squamous cell carcinoma., PMID:30793164
DIAPH3 promotes the tumorigenesis of lung adenocarcinoma., PMID:31586548
Knockdown of formin mDia2 alters lamin B1 levels and increases osteogenesis in stem cells., PMID:31648392
The formin INF2 in disease: progress from 10 years of research., PMID:32451589
Loss of DIAPH3, a Formin Family Protein, Leads to Cytokinetic Failure Only under High Temperature Conditions in Mouse FM3A Cells., PMID:33187357
Novel stromal biomarker screening in pancreatic cancer patients using the in vitro cancer-stromal interaction model., PMID:33297976
DIAPH3 promotes pancreatic cancer progression by activating selenoprotein TrxR1-mediated antioxidant effects., PMID:33345387
Recessive NOS1AP variants impair actin remodeling and cause glomerulopathy in humans and mice., PMID:33523862
Nonredundant roles of DIAPHs in primary ciliogenesis., PMID:33872598
Inhibition of polar actin assembly by astral microtubules is required for cytokinesis., PMID:33893302
DIAPH3 deficiency links microtubules to mitotic errors, defective neurogenesis, and brain dysfunction., PMID:33899739
Confirming the contribution and genetic spectrum of de novo mutation in infantile spasms: Evidence from a Chinese cohort., PMID:33951346
Identification of hub genes in colorectal cancer based on weighted gene co-expression network analysis and clinical data from The Cancer Genome Atlas., PMID:34308980
Formins in Human Disease., PMID:34685534
Identification and verification of key cancer genes associated with prognosis of colorectal cancer based on bioinformatics analysis., PMID:34911835
Diaphanous related formin 3 knockdown suppresses cell proliferation and metastasis of osteosarcoma cells., PMID:35201449
Methylation- and homologous recombination deficiency-related mutant genes predict the prognosis of lung adenocarcinoma., PMID:35238419
Diaph3 underlines tumor cell heterogeneity in glioblastoma with implications for treatment modalities resistance., PMID:35380294
DIAPH3 is a prognostic biomarker and inhibit colorectal cancer progression through maintaining EGFR degradation., PMID:35538918
Role of Cytoskeletal Diaphanous-Related Formins in Hearing Loss., PMID:35681420
Gene expression profiling and in vitro functional studies reveal RAD54L as a potential therapeutic target in multiple myeloma., PMID:35689754
Nutritional and genetic determinants of essential hypertension among adult respondents of the 2013 national nutrition survey, Philippines: a preliminary observational study., PMID:36245136
Diaphanous-related formin subfamily: Novel prognostic biomarkers and tumor microenvironment regulators for pancreatic adenocarcinoma., PMID:36589226
DIAPH3 condensates formed by liquid-liquid phase separation act as a regulatory hub for stress-induced actin cytoskeleton remodeling., PMID:36640348
In-depth genetic and molecular characterization of diaphanous related formin 2 (DIAPH2) and its role in the inner ear., PMID:36689403
The pan-cancer analysis identified DIAPH3 as a diagnostic biomarker of clinical cancer., PMID:36750200
Super Enhancer-Regulated LncRNA LINC01089 Induces Alternative Splicing of DIAPH3 to Drive Hepatocellular Carcinoma Metastasis., PMID:37756562
KIF20B and MET, hub genes of DIAPHs, predict poor prognosis and promote pancreatic cancer progression., PMID:38266456
CircDiaph3 aggravates H/R-induced cardiomyocyte apoptosis and inflammation through miR-338-3p/SRSF1 axis., PMID:38613636
Role of MEK1 and DIAPH3 expression in colorectal adenoma-carcinoma sequence., PMID:38728194
Cellular landscape of adrenocortical carcinoma at single-nuclei resolution., PMID:38759836
Unveiling novel cell clusters and biomarkers in glioblastoma and its peritumoral microenvironment at the single-cell perspective., PMID:38851695
Mutation spectrum of hearing loss patients in Northwest China: Identification of 20 novel variants., PMID:38860500
The DIAPH3 linker specifies a β-actin network that maintains RhoA and Myosin-II at the cytokinetic furrow., PMID:38897998
Stub1 promotes degradation of the activated Diaph3: A negative feedback regulatory mechanism of the actin nucleator., PMID:39322015
Cathepsin C Promotes Tumorigenesis in Bladder Cancer by Activating the Wnt/β-catenin Signalling Pathway., PMID:39344330
The functional DIAPH3-FOXM1 interaction modulates the aggressive transformation of anaplastic thyroid carcinoma cells and Wnt/β-catenin signalling., PMID:39376176
Exploring common pathogenic association between Epstein Barr virus infection and long-COVID by integrating RNA-Seq and molecular dynamics simulations., PMID:39391317
Genome-Wide Association Study for Test-Day Milk Yield, Proteins, and Composition Traits of Crossbred Dairy Cattle in Ethiopia., PMID:39473539
Endocytosis, endoplasmic reticulum, actin cytoskeleton affected in tilapia liver under polystyrene microplastics and BDE153 acute co-exposure., PMID:39725183
m1A-regulated DIAPH3 promotes the invasiveness of colorectal cancer via stabilization of KRT19., PMID:39843730
Chemoproteomics-Enabled De Novo Proteolysis Targeting Chimera Discovery Platform Identifies a Metallothionein Degrader to Probe Its Role in Cancer., PMID:39989026
Advances in Understanding the Molecular Dynamics of Autosomal Dominant Auditory Neuropathy: Unveiling a Novel DIAPH3 Gene Variant Associated With Sensorineural Hearing Loss and Bilateral Vestibular Aqueduct Enlargement., PMID:40040362
For research use only. Not for human or drug use.
