Catalog No.
YHK42801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser23-Tyr303
Predicted molecular weight
34.99 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UNE7
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Antigen NY-CO-7, CHIP, CLL-associated antigen KW-8, STUB1, Carboxy terminus of Hsp70-interacting protein, STIP1 homology and U box-containing protein 1, E3 ubiquitin-protein ligase CHIP, RING-type E3 ubiquitin transferase CHIP
Note
For research use only.
Disease-associated mutations in C-terminus of HSP70 interacting protein (CHIP) impair its ability to negatively regulate mitophagy., PMID:39117117
Peptide Degrader-Based Targeting of METTL3/14 Improves Immunotherapy Response in Cutaneous Melanoma., PMID:39136347
SVIP reduces IGFBP-2 expression and inhibits glioblastoma progression via stabilizing PTEN., PMID:39138166
ITPKA phosphorylates PYCR1 and promotes the progression of glioma., PMID:39170313
The deubiquitinase USP44 enhances cisplatin chemosensitivity through stabilizing STUB1 to promote LRPPRC degradation in neuroblastoma., PMID:39215663
Correlation Between the Expression of DNA Damage Repair Protein OGG1 and Ubiquitination Pathway Protein STUB1 in Pediatric Neuroblastoma., PMID:39219028
Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP., PMID:39266525
STUB1-mediated K63-linked ubiquitination of UHRF1 promotes the progression of cholangiocarcinoma by maintaining DNA hypermethylation of PLA2G2A., PMID:39267107
[Sanguinarine induces ferroptosis of colorectal cancer cells by upregulating STUB1 and downregulating GPX4]., PMID:39276049
Stub1 promotes degradation of the activated Diaph3: A negative feedback regulatory mechanism of the actin nucleator., PMID:39322015
The Delayed Turnover of Proteasome Processing of Myocilin upon Dexamethasone Stimulation Introduces the Profiling of Trabecular Meshwork Cells' Ubiquitylome., PMID:39337505
O-GlcNAcylation of enolase 1 serves as a dual regulator of aerobic glycolysis and immune evasion in colorectal cancer., PMID:39446384
STUB1-mediated ubiquitination and degradation of NSUN2 promotes hepatocyte ferroptosis by decreasing m5C methylation of Gpx4 mRNA., PMID:39453812
CHIP drives proteasomal degradation of NUR77 to alleviate oxidative stress and intrinsic apoptosis in cisplatin-induced nephropathy., PMID:39462094
Combined targeting of GPX4 and BCR-ABL tyrosine kinase selectively compromises BCR-ABL+ leukemia stem cells., PMID:39465372
STAT6 promotes innate immunity against BEFV and VSV by inhibiting STUB1 and NIX-mediated MAVS degradation., PMID:39471658
Deciphering the regulatory mechanisms and biological implications of ARID1A missense mutations in cancer., PMID:39475510
HSP70 promotes amino acid-dependent mTORC1 signaling by mediating CHIP-induced NPRL2 ubiquitination and degradation., PMID:39495541
STUB1 suppresses paclitaxel resistance in ovarian cancer through mediating HOXB3 ubiquitination to inhibit PARK7 expression., PMID:39501077
The UBA1-STUB1 Axis Mediates Cancer Immune Escape and Resistance to Checkpoint Blockade., PMID:39540840
HNRNPH1 stabilizes FLOT2 mRNA in a non-canonical m6A-dependent manner to promote malignant progression in nasopharyngeal carcinoma., PMID:39570559
Treponema Pallidum protein Tp47 triggers macrophage inflammatory senescence via PKM2-mediated metabolic reprogramming., PMID:39581401
Case Series of Cerebellar Ataxia with Tremor Due to Heterozygous STUB1 Variants (SCA48) without TBP Expansions: Further Evidence for SCA48 as a Monogenic Disease., PMID:39680235
Autophagy promotes p72 degradation and capsid disassembly during the early phase of African swine fever virus infection., PMID:39688418
Clinical and functional characterization of a novel STUB1 mutation in a Chinese spinocerebellar ataxia 48 pedigree., PMID:39707479
Cabozantinib selectively induces proteasomal degradation of p53 somatic mutant Y220C and impedes tumor growth., PMID:39793887
E3 ubiquitin ligase CHIP facilitates cAMP and cGMP signalling cross-talk by polyubiquitinating PDE9A., PMID:39806097
A novel peptide encoded by circSRCAP confers resistance to enzalutamide by inhibiting the ubiquitin-dependent degradation of AR-V7 in castration-resistant prostate cancer., PMID:39844192
Recombinant antibodies inhibit enzymatic activity of the E3 ubiquitin ligase CHIP via multiple mechanisms., PMID:39863102
The Ubiquitin Ligase CHIP Accelerates Papillary Thyroid Carcinoma Metastasis via the Transgelin-Matrix Metalloproteinase-9 Axis., PMID:39869438
TBP Repeat Expansion Analysis in Patients Carrying Heterozygous STUB1 Variants., PMID:39950762
Androgen receptor ubiquitination links KCTD13 to genitourinary tract defects., PMID:39968753
Lanatoside C activates the E3 ligase STUB1 to inhibit FOXP3 transcriptional activity and promote antitumor immunity., PMID:39979425
Targeting AKT as a promising strategy for SOX2-positive, chemoresistant osteosarcoma., PMID:39994220
SENP3 Drives Abdominal Aortic Aneurysm Development by Regulating Ferroptosis via De-SUMOylation of CTH., PMID:40019399
Stub1 Acetylation by CBP/p300 Attenuates Chronic Hypoxic-driven Pulmonary Hypertension by Suppressing HIF-2α., PMID:40019849
Cerebrospinal fluid HSP90AA1, HSPA4, and STUB1/CHIP levels in Alzheimer's disease, mild cognitive impairment, and frontotemporal dementia., PMID:40116694
Association between hyperlipidemia and nephrolithiasis: A comprehensive bioinformatics analysis deciphering the potential common denominator pathogenesis., PMID:40245021
Decoding the role of nucleic acid binding protein 2 in lipid dysregulation and hepatocellular carcinoma progression through LKB1-mediated mitochondrial dysfunction., PMID:40250697
Doublecortin-like kinase 1, regulated by STIP1 homology and U-box containing protein 1 or Sp1 transcription factor, affects the malignant behaviors and drug sensitivity in adriamycin-resistant breast cancer cells., PMID:40257489
Inhibition of FOXD3 O-GlcNAc Modification Ameliorates Spinal Cord Injury by Promoting STUB1-Mediated Ubiquitination Degradation of HMGB1., PMID:40272767
LINC00926, Regulated by TCF12, Modulates the Ubiquitination of GPX4 to Regulate Ferroptosis by Interacting with STUB1 in HUVECs., PMID:40295445
CHIP and aging: a key regulator of proteostasis and cellular senescence., PMID:40323531
STUB1-mediated ubiquitination of SLC25A10 regulates mitochondrial function and drives osteosarcoma progression: A novel therapeutic target., PMID:40349811
BAG2 Inhibits Cervical Cancer Progression by Modulating Type I Interferon Signaling through Stabilizing STING., PMID:40364789
Machine Learning-Based Multimodal Radiomics and Transcriptomics Models for Predicting Radiotherapy Sensitivity and Prognosis in Esophageal Cancer., PMID:40381695
Asb10 accelerates pathological cardiac remodeling by stabilizing HSP70., PMID:40399264
A novel nonsense mutation of the glucocorticoid receptor gene causing glucocorticoid resistance with infertility., PMID:40413280
Structures of Fab-stabilized CHIP reveal a conformational switch important in E3 ligase and chaperone functions., PMID:40463190
For research use only. Not for human or drug use.
