Catalog No.
YHK42701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Leu134-Asp366
Predicted molecular weight
29.27 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96T88
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Nuclear zinc finger protein Np95, RING-type E3 ubiquitin transferase UHRF1, RING finger protein 106, Transcription factor ICBP90, E3 ubiquitin-protein ligase UHRF1, Ubiquitin-like PHD and RING finger domain-containing protein 1, NP95, HuNp95, Nuclear protein 95, RNF106, ICBP90, hNp95, UHRF1, Inverted CCAAT box-binding protein of 90 kDa, hUHRF1, Ubiquitin-like-containing PHD and RING finger domains protein 1
Note
For research use only.
The expression and clinical significance of UHRF1 in soft tissue sarcomas and its prognostic value., PMID:38847665
Integrated bioinformatics combined with machine learning to analyze shared biomarkers and pathways in psoriasis and cervical squamous cell carcinoma., PMID:38863714
The maternal protein NLRP5 stabilizes UHRF1 in the cytoplasm: implication for the pathogenesis of multilocus imprinting disturbance., PMID:38868925
Interferon regulatory factor 4 modulates epigenetic silencing and cancer-critical pathways in melanoma cells., PMID:38880659
Maternal loss-of-function of Nlrp2 results in failure of epigenetic reprogramming in mouse oocytes., PMID:38883732
Structure of human DPPA3 bound to the UHRF1 PHD finger reveals its functional and structural differences from mouse DPPA3., PMID:38898124
Identification of ubiquitination-related hub genes in chronic myeloid leukemia cell by bioinformatics analysis., PMID:38911390
KHSRP has oncogenic functions and regulates the expression and alternative splicing of DNA repair genes in breast cancer MDA-MB-231 cells., PMID:38926398
New insights into oocyte cytoplasmic lattice-associated proteins., PMID:38955588
DiPRO1 distinctly reprograms muscle and mesenchymal cancer cells., PMID:39009887
Oncogenic Roles of UHRF1 in Cancer., PMID:39051184
Identification of differentially expressed tumour-related genes regulated by UHRF1-driven DNA methylation., PMID:39112494
Genetics of Cardiac Aging Implicate Organ-Specific Variation., PMID:39148824
CDCA7 is an evolutionarily conserved hemimethylated DNA sensor in eukaryotes., PMID:39178260
The scaffolding function of LSD1 controls DNA methylation in mouse ESCs., PMID:39237615
STUB1-mediated K63-linked ubiquitination of UHRF1 promotes the progression of cholangiocarcinoma by maintaining DNA hypermethylation of PLA2G2A., PMID:39267107
UHRF1 knockdown induces cell cycle arrest and apoptosis in breast cancer cells through the ZBTB16/ANXA7/Cyclin B1 axis., PMID:39308302
UHRF1-mediated ubiquitination of nonhomologous end joining factor XLF promotes DNA repair in human tumor cells., PMID:39341501
Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response., PMID:39362877
Gene expression profile analysis of severe influenza-based modulation of idiopathic pulmonary fibrosis., PMID:39420432
Integrating machine learning and bioinformatics approaches for identifying novel diagnostic gene biomarkers in colorectal cancer., PMID:39433800
[Expression and localization of Uhrf1 in the major reproductive organs of yaks during different reproductive cycles]., PMID:39467768
The Roles of H3K9me3 Writers, Readers, and Erasers in Cancer Immunotherapy., PMID:39519018
Analyses of Off-Target Effects on Cardiac and Skeletal Muscles by Berberine, a Drug Used to Treat Cancers and Induce Weight Loss., PMID:39526308
UHRF1 ubiquitin ligase activity supports the maintenance of low-density CpG methylation., PMID:39607687
RAD51 plays critical roles in DNMT1-mediated maintenance methylation of genomic DNA by dually regulating the ubiquitin ligase UHRF1., PMID:39621902
DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states., PMID:39631394
SIRT6 deficiency impairs the deacetylation and ubiquitination of UHRF1 to strengthen glycolysis and lactate secretion in bladder cancer., PMID:39709438
An Integrated Framework to Identify Prognostic Biomarkers and Novel Therapeutic Targets in Hepatocellular Carcinoma-Based Disabilities., PMID:39765633
Defining ortholog-specific UHRF1 inhibition by STELLA for cancer therapy., PMID:39774694
Targeting of the G9a, DNMT1 and UHRF1 epigenetic complex as an effective strategy against pancreatic ductal adenocarcinoma., PMID:39810240
UHRF1 promotes epithelial-mesenchymal transition mediating renal fibrosis by activating the TGF-β/SMAD signaling pathway., PMID:39870702
UHRF1 promotes calcium oxalate-induced renal fibrosis by renal lipid deposition via bridging AMPK dephosphorylation., PMID:39899077
Structure-Activity Relationship Studies of DNA Methyltransferase 1 Monovalent Degraders., PMID:39905966
Potentiating anti-tumor immunity by re-engaging immune synapse molecules., PMID:39999838
Epigenetic ALYREF/UHRF1/RHOB Axis in Corneal Wound Healing and Implications for Epithelial Tumorigenesis., PMID:40131294
Negative Cooperativity in the UHRF1 TTD-PHD Dual Domain Masks the Contributions of Cation-π Interactions between Trimethyllysine and the TTD Aromatic Cage., PMID:40202581
Epigenetic regulation of physiological resilience to ammonia nitrogen stress in the Pacific whiteleg shrimp Penaeus vannamei: Evidence from genome-wide DNA methylation dynamics., PMID:40220697
Identification of Novel Therapeutic Targets for MAFLD Based on Bioinformatics Analysis Combined with Mendelian Randomization., PMID:40243942
Ubiquitin-proteasome Pathway-linked Gene Signatures as Prognostic Indicators in Prostate Cancer., PMID:40295064
Epigenetic silencing of DNA sensing pathway by FOXM1 blocks stress ligand-dependent antitumor immunity and immune memory., PMID:40295473
UHRF1-mediated epigenetic reprogramming regulates glycolysis to promote progression of B-cell acute lymphoblastic leukemia., PMID:40301374
NKX2-5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic Dysregulation., PMID:40307990
Mechanism of UHRF1 protein macromolecule regulating ferroptosis in liver cancer: inhibition of GSTZ1 expression through DNA methylation., PMID:40348248
Dual DNA demethylation mechanisms implement epigenetic memory driven by the pioneer factor PAX7., PMID:40378211
Synergistic regulation of DACH1 stability by acetylation and deubiquitination promotes colorectal cancer progression., PMID:40389405
Systematic analysis of the aberrances and functional implications of epigenetic genes in hepatocellular carcinoma., PMID:40423892
RAC1 Regulates Shh-Medulloblastoma Growth via GLI-Mediated Transcription., PMID:40475618
Congenital diseases with defects in DNA methylation maintenance: Focusing on ICF syndrome and multilocus imprinting disturbance., PMID:40500184
The Role of miR-124-3p/UHRF1 in NaAsO2-Induced Apoptosis of LX-2 Cells via DNMT1/SOCS1., PMID:40509639
For research use only. Not for human or drug use.
