Catalog No.
YHK42301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala187-Ile563
Predicted molecular weight
44.50 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NR30
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% SKL, 1mM EDTA, 5% Trehalose, 2% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DEAD box protein 21, DDX21, Gu-alpha, Nucleolar RNA helicase II, RH II/Gu, Nucleolar RNA helicase Gu, Nucleolar RNA helicase 2
Note
For research use only.
Identification of Signal Pathways and Hub Genes of Pulmonary Arterial Hypertension by Bioinformatic Analysis., PMID:36072642
SARS-CoV-2 Variants Show a Gradual Declining Pathogenicity and Pro-Inflammatory Cytokine Stimulation, an Increasing Antigenic and Anti-Inflammatory Cytokine Induction, and Rising Structural Protein Instability: A Minimal Number Genome-Based Approach., PMID:36215001
Pan-cancer analysis reveals DDX21 as a potential biomarker for the prognosis of multiple tumor types., PMID:36505822
Sweet splicing., PMID:36608648
Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation., PMID:36608661
[Anti-infectious pneumonia target discovery and molecular mechanism study of Jingfang Granules]., PMID:36872243
Phase separation of DDX21 promotes colorectal cancer metastasis via MCM5-dependent EMT pathway., PMID:37029300
Homology directed telomere clustering, ultrabright telomere formation and nuclear envelope rupture in cells lacking TRF2B and RAP1., PMID:37059728
LINC00240 in the 6p22.1 risk locus promotes gastric cancer progression through USP10-mediated DDX21 stabilization., PMID:37072811
The RNA-Splicing Ligase RTCB Promotes Influenza A Virus Replication by Suppressing Innate Immunity via Interaction with RNA Helicase DDX1., PMID:37556111
Pirh2-dependent DNA damage in neurons induced by the G-quadruplex ligand pyridostatin., PMID:37579947
Identification and characterization of colorectal-cancer-associated SNPs on the SMAD7 locus., PMID:37721570
Label-Free Quantitative Thermal Proteome Profiling Reveals Target Transcription Factors with Activities Modulated by MC3R Signaling., PMID:37804223
ADAR1 links R-loop homeostasis to ATR activation in replication stress response., PMID:37831098
RRP9 and DDX21 as new biomarkers of colorectal cancer., PMID:37904456
Nucleolus activity-dependent recruitment and biomolecular condensation by pH sensing., PMID:37979585
Joint effect of RRP9 and DDX21 on development of colorectal cancer and keloid., PMID:37988222
Disclosing Potential Therapeutic Targets Associated With Osimertinib Resistance in the Non-small Cell Lung Cancer Cell Line H1975., PMID:38030186
Multiscale protein networks systematically identify aberrant protein interactions and oncogenic regulators in seven cancer types., PMID:38102665
DEAD-box RNA helicase 21 interacts with porcine circovirus type 2 Cap protein and facilitates viral replication., PMID:38380105
Lnc-PLCB1 is stabilized by METTL14 induced m6A modification and inhibits Helicobacter pylori mediated gastric cancer by destabilizing DDX21., PMID:38387756
DDX21 mediates co-transcriptional RNA m6A modification to promote transcription termination and genome stability., PMID:38569554
m6A-dependent upregulation of DDX21 by super-enhancer-driven IGF2BP2 and IGF2BP3 facilitates progression of acute myeloid leukaemia., PMID:38572589
DDX21: The link between m6A and R-loops., PMID:38701738
U3 snoRNA inter-regulates with DDX21 in the perichromosomal region to control mitosis., PMID:38760378
Current understanding of the role of DDX21 in orchestrating gene expression in health and diseases., PMID:38762067
Nucleolar Localization of the RNA Helicase DDX21 Predicts Survival Outcomes in Gynecologic Cancers., PMID:38767454
Energy stress-induced circDDX21 promotes glycolysis and facilitates hepatocellular carcinogenesis., PMID:38773094
A chemical probe to modulate human GID4 Pro/N-degron interactions., PMID:38773330
DDX21 is a new player in co-transcriptional RNA modification and functions., PMID:38995490
DHX9 SUMOylation is required for the suppression of R-loop-associated genome instability., PMID:39019926
Calmodulin Triggers Activity-Dependent rRNA Biogenesis via Interaction with DDX21., PMID:39060175
DDX21 functions as a potential novel oncopromoter in pancreatic ductal adenocarcinoma: a comprehensive analysis of the DExD box family., PMID:39095628
Exploration of PVT1 as a biomarker in prostate cancer., PMID:39183420
TRIP13 regulates progression of gastric cancer through stabilising the expression of DDX21., PMID:39187490
The RNA helicase DDX21 activates YAP to promote tumorigenesis and is transcriptionally upregulated by β-catenin in colorectal cancer., PMID:39285230
The Prospective role of lapatinib as an adjuvant therapy in prevalent cancers: Insights from in silico analysis targeting EGFR and HER2., PMID:39369912
NAT10 resolves harmful nucleolar R-loops depending on its helicase domain and acetylation of DDX21., PMID:39394182
CircRNA-RBAC induces cardiac repair by promoting ribosome biogenesis and cell cycle progression in cardiomyocytes., PMID:39643169
DExD-Box Helicase 21 Enhances Myometrial Contractions Through Thrombospondin-1-Mediated Increase in Cell Adhesion., PMID:39690141
Impact of liquid-liquid phase separation- and immune-related gene signatures on multiple myeloma prognosis: focus on DDX21 and EZH2., PMID:39713879
DDX21 at the Nexus of RNA Metabolism, Cancer Oncogenesis, and Host-Virus Crosstalk: Decoding Its Biomarker Potential and Therapeutic Implications., PMID:39769343
DDX21 Is a Potential Biomarker for Predicting Recurrence and Prognosis in Hepatocellular Carcinoma., PMID:39866844
DEAD-box protein 21 promotes renal fibrosis via p21-dependent cell cycle arrest in proximal tubular epithelial cells., PMID:39938704
The liver-specific long noncoding RNA FAM99B inhibits ribosome biogenesis and cancer progression through cleavage of dead-box Helicase 21., PMID:39952918
DDX21 Promotes PCV3 Replication by Binding to Cap Protein and Inhibiting Interferon Responses., PMID:40006921
m6A-induced DEAD-box RNA helicase 21 enhances lipid metabolism via 3‑hydroxy-3-methylglutaryl-CoA synthases 1 in colorectal cancer., PMID:40127603
Competitive binding between DDX21 and SIRT7 enhances NAT10-mediated ac4C modification to promote colorectal cancer metastasis and angiogenesis- DDX21 promotes colorectal cancer metastasis., PMID:40301349
Epigenetic Silencing of miR-218-5p Modulates BIRC5 and DDX21 Expression to Promote Colorectal Cancer Progression., PMID:40362385
GPATCH4 functions as a regulator of nucleolar R-loops in hepatocellular carcinoma cells., PMID:40401559
For research use only. Not for human or drug use.
