Catalog No.
YHK21801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn17-Ala354
Predicted molecular weight
41.28 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q6B0I6
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Lysine-specific demethylase 4D, JHDM3D, [histone H3]-trimethyl-L-lysine(9) demethylase 4D, KDM4D, JmjC domain-containing histone demethylation protein 3D, JMJD2D, Jumonji domain-containing protein 2D
Note
For research use only.
Treatment of donor cells with recombinant KDM4D protein improves preimplantation development of cloned ovine embryos., PMID:29766333
Repressive histone methylation regulates cardiac myocyte cell cycle exit., PMID:29800554
Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1β/VEGFA signalling., PMID:30060750
Histone Demethylase JMJD2D Interacts With β-Catenin to Induce Transcription and Activate Colorectal Cancer Cell Proliferation and Tumor Growth in Mice., PMID:30472235
The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathway., PMID:30527625
A novel missense mutation within the domain of lysine demethylase 4D (KDM4D) gene is strongly associated with testis morphology traits in pigs., PMID:30614375
Structure-Based Screening of Tetrazolylhydrazide Inhibitors versus KDM4 Histone Demethylases., PMID:31475772
Enhancement of Radiosensitivity by Eurycomalactone in Human NSCLC Cells Through G₂/M Cell Cycle Arrest and Delayed DNA Double-Strand Break Repair., PMID:31727206
Advances in histone demethylase KDM4 as cancer therapeutic targets., PMID:31961018
Histone demethylase KDM4D cooperates with NFIB and MLL1 complex to regulate adipogenic differentiation of C3H10T1/2 mesenchymal stem cells., PMID:32080306
Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling., PMID:32094404
Aberrant DNA and histone methylation during zygotic genome activation in goat cloned embryos., PMID:32126393
Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos., PMID:32286279
High-resolution annotation of the mouse preimplantation embryo transcriptome using long-read sequencing., PMID:32461551
H3K9me3 maintenance on a human artificial chromosome is required for segregation but not centromere epigenetic memory., PMID:32576667
Demethylase-independent function of JMJD2D as a novel antagonist of p53 to promote Liver Cancer initiation and progression., PMID:32754284
Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression., PMID:32989255
Histone demethylase JMJD2D promotes the self-renewal of liver cancer stem-like cells by enhancing EpCAM and Sox9 expression., PMID:33434575
Crystal structures of two inhibitors in complex with histone lysine demethylase 4D (KDM4D) provide new insights for rational drug design., PMID:33780862
Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D., PMID:34237635
The chemotherapeutic drug carboplatin affects macrophage responses to LPS and LPS tolerance via epigenetic modifications., PMID:34732786
Epigenetic Regulator KDM4D Restricts Tumorigenesis via Modulating SYVN1/HMGB1 Ubiquitination Axis in Esophageal Squamous Cell Carcinoma., PMID:34820329
Demethylase JMJD2D induces PD-L1 expression to promote colorectal cancer immune escape by enhancing IFNGR1-STAT3-IRF1 signaling., PMID:35027670
TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation., PMID:35145029
The TRIM14-USP14-BRCC3 complex epigenetically regulates inflammation through inhibiting OPTN-mediated autophagic degradation of KDM4D., PMID:35311471
Pentoxifylline-induced protein expression change in RAW 264.7 cells as determined by immunoprecipitation-based high performance liquid chromatography., PMID:35333871
JIB-04, a Pan-Inhibitor of Histone Demethylases, Targets Histone-Lysine-Demethylase-Dependent AKT Pathway, Leading to Cell Cycle Arrest and Inhibition of Cancer Stem-Like Cell Properties in Hepatocellular Carcinoma Cells., PMID:35887001
KDM4D enhances osteo/dentinogenic differentiation and migration of SCAPs via binding to RPS5., PMID:36579641
Hippo signaling and histone methylation control cardiomyocyte cell cycle re-entry through distinct transcriptional pathways., PMID:36780463
Dieting reverses histone methylation and hypothalamic AgRP regulation in obese rats., PMID:36817590
Effects of overexpression of histone H3K9me3 demethylase on development of porcine cloned embryos., PMID:36927639
Spatial Multiplexed Protein Profiling of Cardiac Ischemia-Reperfusion Injury., PMID:37249015
Control of enhancer and promoter activation in the type I interferon response by the histone demethylase Kdm4d/JMJD2d., PMID:37275914
Overcoming the H4K20me3 epigenetic barrier improves somatic cell nuclear transfer reprogramming efficiency in mice., PMID:37322828
Lysine-Specific Demethylase 4D Is Critical for the Regulation of the Cell Cycle and Antioxidant Capacity in Goat Fibroblast Cells., PMID:37626981
MicroRNA-409-5p Inhibits GIST Tumorigenesis and Improves Imatinib Resistance by Targeting KDM4D Expression., PMID:37828372
Tanshinone I induces ferroptosis in gastric cancer cells via the KDM4D/p53 pathway., PMID:37989263
Specific serum autoantibodies predict the development and progression of Alzheimer's disease with high accuracy., PMID:37989443
Methylation of the epigenetic JMJD2D protein by SET7/9 promotes prostate tumorigenesis., PMID:38045004
Targeting MMP9 in CTNNB1 mutant hepatocellular carcinoma restores CD8+ T cell-mediated antitumour immunity and improves anti-PD-1 efficacy., PMID:38123979
Elevated KDM4D Expression in Pterygium: Impact and Potential Inhibition by Lycium Barbarum Polysaccharide., PMID:38386983
Histone demethylase JMJD2D protects against enteric bacterial infection via up-regulating colonic IL-17F to induce β-defensin expression., PMID:38905308
Structure-based mapping of the histone-binding pocket of KDM4D using functionalized tetrazole and pyridine core compounds., PMID:38981336
Kdm4d mutant mice show impaired sperm motility and subfertility., PMID:39034148
Iron-dependent KDM4D activity controls the quiescence-activity balance of MSCs via the PI3K-Akt-Foxo1 pathway., PMID:39158700
H3K9me3 Levels Affect the Proliferation of Bovine Spermatogonial Stem Cells., PMID:39273164
Design, synthesis and biological evaluation of 4,6-diarylquinoxaline-based KDM4D inhibitors., PMID:39454559
JmjC catalysed histone H2a N-methyl arginine demethylation and C4-arginine hydroxylation reveals importance of sequence-reactivity relationships., PMID:39604683
Discovery of a first-in-class PROTAC degrader of histone lysine demethylase KDM4., PMID:39978110
USP14 inhibits sensitization-mediated degradation of KDM4D to epigenetically regulate dendritic cell tolerogenic capacity and mitigates airway allergy., PMID:40088847
For research use only. Not for human or drug use.
