Catalog No.
YHE28701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln65-Thr299
Predicted molecular weight
27.62 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P40967
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
ME20M, Melanocyte protein PMEL, Silver locus protein homolog, Secreted melanoma-associated ME20 antigen, D12S53E, 95 kDa melanocyte-specific secreted glycoprotein, SILV, P100, Premelanosome protein, PMEL17, ME20S, PMEL, ME20-S, ME20-M, P26, P1, Melanocytes lineage-specific antigen GP100, Melanocyte protein Pmel 17, Melanoma-associated ME20 antigen
Note
For research use only.
CDK1 promotes the proliferation of melanocytes in Rex rabbits., PMID:35951158
Human milk oligosaccharide 2'-fucosyllactose promotes melanin degradation via the autophagic AMPK-ULK1 signaling axis., PMID:35977966
PMEL is mutated in oculocutaneous albinism., PMID:36166100
OCA7 is a melanosome membrane protein that defines pigmentation by regulating early stages of melanosome biogenesis., PMID:36334630
Genetically engineered multicistronic allele of Pmel yielding highly specific CreERT2-mediated recombination in the melanocyte lineage., PMID:36412082
Targeting the CD47/thrombospondin-1 signaling axis regulates immune cell bioenergetics in the tumor microenvironment to potentiate antitumor immune response., PMID:36418073
Inflammatory Cytokines That Enhance Antigen Responsiveness of Naïve CD8+ T Lymphocytes Modulate Chromatin Accessibility of Genes Impacted by Antigen Stimulation., PMID:36430600
NRAS promotes the proliferation of melanocytes to increase melanin deposition in Rex rabbits., PMID:36440769
Intracavitary adoptive transfer of IL-12 mRNA-engineered tumor-specific CD8+ T cells eradicates peritoneal metastases in mouse models., PMID:36531687
7-desacetoxy-6,7-dehydrogedunin discovered by high-throughput screening system suppresses melanogenesis through ATP-P2X7 signaling inhibition., PMID:36610940
The CNC-family transcription factor Nrf3 coordinates the melanogenesis cascade through macropinocytosis and autophagy regulation., PMID:36640303
The genetic basis and potential molecular mechanism of yellow-albino northern snakehead (Channa argus)., PMID:36789536
UPLC-MS based integrated plasma proteomic and metabolomic profiling of TSC-RAML and its relationship with everolimus treatment., PMID:36891236
mRNAs encoding IL-12 and a decoy-resistant variant of IL-18 synergize to engineer T cells for efficacious intratumoral adoptive immunotherapy., PMID:36933554
Ubiquitin-specific protease 34 in macrophages limits CD8 T cell-mediated onset of vitiligo in mice., PMID:37043976
Association analysis of PMEL gene expression and single nucleotide polymorphism with plumage color in quail., PMID:37300547
Biogenesis of fibrils requires C-mannosylation of PMEL., PMID:37552474
Physiological responses of scallops and mussels to environmental variability: Implications for future shellfish aquaculture., PMID:37633025
Requirements for anti-aquaporin 5 autoantibody production in a mouse model., PMID:37718989
Disrupting the Repeat Domain of Premelanosome Protein (PMEL) Produces Dysamyloidosis and Dystrophic Ocular Pigment Reflective of Pigmentary Glaucoma., PMID:37833870
Anti-Inflammatory Artificial Extracellular Vesicles with Notable Inhibition of Particulate Matter-Induced Skin Inflammation and Barrier Function Impairment., PMID:37983083
Loss of REP1 impacts choroidal melanogenesis and vasculogenesis in choroideremia., PMID:37989423
CanVaxKB: a web-based cancer vaccine knowledgebase., PMID:38204924
Genetic basis and expression of ventral colour in polymorphic common lizards., PMID:38268086
Genetic Basis of Pigment Dispersion Syndrome and Pigmentary Glaucoma: An Update and Functional Insights., PMID:38397132
Identification of gravity-responsive serum proteins in spaceflight mice using a quantitative proteomic approach with data-independent acquisition mass spectrometry., PMID:38475964
Digital spatial proteomic profiling reveals immune checkpoints as biomarkers in lymphoid aggregates and tumor microenvironment of desmoplastic melanoma., PMID:38519058
Simultaneous targeted and discovery-driven clinical proteotyping using hybrid-PRM/DIA., PMID:38565978
PRAME and Historical Immunohistochemical Antibodies Ki-67, P16, and HMB-45 in Ambiguous Melanocytic Tumors., PMID:38916203
DOK1 and DOK2 regulate CD8 T cell signaling and memory formation without affecting tumor cell killing., PMID:38956389
Oxidized Melanoma Antigens Promote Activation and Proliferation of Cytotoxic T-Cell Subpopulations., PMID:38958560
Lung Adenocarcinoma Systems Biomarker and Drug Candidates Identified by Machine Learning, Gene Expression Data, and Integrative Bioinformatics Pipeline., PMID:38979602
In Situ Protein Expression Analysis of Melanocyte Differentiation Antigen TRP1 (Tyrosinase-Related Protein-1)., PMID:39008470
[TFE3-rearranged perivascular epithelioid cell tumors: a clinicopathological analysis of eight cases]., PMID:39103264
[Clinicopathological features of metastatic melanoma in effusion cytology of serosal cavity]., PMID:39103266
GP100 expression is variable in intensity in melanoma., PMID:39105816
Transcriptomic and Metabolomic Analyses Reveal Molecular Regulatory Networks for Pigmentation Deposition in Sheep., PMID:39125816
PMEL is a predictive biomarker for mTORC1 inhibitor treatment of renal angiomyolipoma in tuberous sclerosis complex patients., PMID:39170496
PMEL is involved in snake colour pattern transition from blotches to stripes., PMID:39227572
Transcriptome-based screening and validation of key genes for wool color in cashmere goats., PMID:39259488
[Cutaneous clear cell sarcoma: a clinicopathological and molecular genetic analysis]., PMID:39482051
Imperatorin promotes melanin degradation in keratinocytes through facilitating autophagy via the PI3K/Akt signaling pathway., PMID:39636461
A high-quality assembly revealing the PMEL gene for the unique plumage phenotype in Liancheng ducks., PMID:39804725
CD93 blockade promotes effector T-cell infiltration and facilitates adoptive cell therapy in solid tumors., PMID:39805660
The Development of Methods of BLOTCHIP®-MS for Peptidome: Small Samples in Tuberous Sclerosis., PMID:39852149
SMARCB1-deficient malignant melanocytic uveal tumours: a new neural crest-derived tumour entity with SMARCB1-related germline predisposition., PMID:39853675
Congenital Cutaneous Neurocristic Hamartoma of the Scalp with Poor Melanin Content., PMID:40232281
Inhibition of Tyrosinase and Melanogenesis by Carboxylic Acids: Mechanistic Insights and Safety Evaluation., PMID:40286213
Botulinum neurotoxin type DC (BoNT/DC) cleavage of VAMP3 reduces melanin production in melanocytes., PMID:40286827
Soyasaponin-I Attenuates Melanogenesis through Activation of ERK and Suppression of PKA/CREB Signaling Pathways., PMID:40352530
For research use only. Not for human or drug use.
