Catalog No.
YHK40201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser39-Arg191
Predicted molecular weight
19.78 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99623
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Repressor of estrogen receptor activity, B-cell receptor-associated protein BAP37, D-prohibitin, BAP, Prohibitin-2, PHB2, REA
Note
For research use only.
THBru attenuates diabetic cardiomyopathy by inhibiting RAGE-dependent inflammation., PMID:38862818
Targeting PHB2-mediated mitophagy alleviates nonesterified fatty acid-induced mitochondrial dysfunction in bovine mammary epithelial cells., PMID:38876225
Prx1/PHB2 axis mediates mitophagy in oral leukoplakia cellular senescence., PMID:38936092
The role of EMG1 in lung adenocarcinoma progression: Implications for prognosis and immune cell infiltration., PMID:38943975
Epidemiology of Clostridioides difficile infection at one hospital 10 years after an outbreak of the epidemic C. difficile strain BI/027: changing strain prevalence, antimicrobial susceptibilities, and patient antibiotic exposures., PMID:38953622
Trafficking of mitochondrial double-stranded RNA from mitochondria to the cytosol., PMID:38955468
Prohibitins, Phb1 and Phb2, function as Atg8 receptors to support yeast mitophagy and also play a negative regulatory role in Atg32 processing., PMID:38964378
Activation of nemo-like kinase in diamond blackfan anemia suppresses early erythropoiesis by preventing mitochondrial biogenesis., PMID:38992436
HLA-B5 prevalence in patients with spondyloarthritis and impact on disease phenotype: a multicentric case-control study., PMID:39018174
Corosolic acid attenuates cardiac ischemia/reperfusion injury through the PHB2/PINK1/parkin/mitophagy pathway., PMID:39091464
Mitophagy Promotes Hair Regeneration by Activating Glutathione Metabolism., PMID:39091635
Role of AMBRA1 in mitophagy regulation: emerging evidence in aging-related diseases., PMID:39113560
Phosphoglycerate mutase 5 exacerbates alcoholic cardiomyopathy in male mice by inducing prohibitin-2 dephosphorylation and impairing mitochondrial quality control., PMID:39143739
Blockade of the lncRNA-PART1-PHB2 axis confers resistance to PARP inhibitor and promotes cellular senescence in ovarian cancer., PMID:39181433
The benzoylphenylurea derivative BPU17 acts as an inhibitor of prohibitin and exhibits antifibrotic activity., PMID:39182665
Prohibitin 2 confers NADPH oxidase 1-mediated cytosolic oxidative signaling to promote gastric cancer progression by ERK activation., PMID:39182738
Loss of prohibitin 2 in Schwann cells dysregulates key transcription factors controlling developmental myelination., PMID:39215540
Host restriction factor Rab11a limits porcine epidemic diarrhea virus invasion of cells via fusion peptide-mediated membrane fusion., PMID:39233171
Host restriction factor Rab11a limits Porcine deltacoronavirus invasion of cells via fusion peptide-mediated membrane fusion., PMID:39244909
Unravelling the anti-apoptotic role of Plasmodium falciparum Prohibitin-2 (PfPhb2) in maintaining mitochondrial homeostasis., PMID:39245193
Targeted proteomics addresses selectivity and complexity of protein degradation by autophagy., PMID:39245437
Identification of Nontuberculous Mycobacterium Species by Polymerase Chain Reaction - Restriction Enzyme Analysis (PCR-REA) of rpoB gene in Clinical Isolates., PMID:39277894
The tumor suppressor Parkin exerts anticancer effects through regulating mitochondrial GAPDH activity., PMID:39285229
Treatment of Reactive Arthritis with Biological Agents., PMID:39312088
YouTube as a source of information on reactive arthritis: a quality analysis., PMID:39320505
Prohibitin 2 orchestrates long noncoding RNA and gene transcription to accelerate tumorigenesis., PMID:39333493
HKDC1 functions as a glucose sensor and promotes metabolic adaptation and cancer growth via interaction with PHB2., PMID:39375512
Identification and characterization of a novel small viral peptide (VSP59) encoded by Bombyx mori cypovirus (BmCPV) that negatively regulates viral replication., PMID:39382281
High glucose- or AGE-induced oxidative stress inhibits hippocampal neuronal mitophagy through the Keap1-Nrf2-PHB2 pathway in diabetic encephalopathy., PMID:39402106
PHB2 alleviates retinal pigment epithelium cell fibrosis by suppressing the AGE-RAGE pathway., PMID:39507806
Efficient PHB2 (prohibitin 2) exposure during mitophagy depends on VDAC1 (voltage dependent anion channel 1)., PMID:39513197
[Reactive arthritis]., PMID:39621046
Mitochondrial targeting of Candida albicans SPFH proteins and requirement of stomatins for SDS-induced stress tolerance., PMID:39641539
Prohibitin 1 tethers lipid membranes and regulates OPA1-mediated membrane fusion., PMID:39675719
Aldehyde Dehydrogenase 2 Lactylation Aggravates Mitochondrial Dysfunction by Disrupting PHB2 Mediated Mitophagy in Acute Kidney Injury., PMID:39737891
Prohibitins in infection: potential therapeutic targets., PMID:39881489
Salmonella Typhimurium persistently infects host via its effector SseJ-induced PHB2-mediated mitophagy., PMID:39902787
A Novel Polysaccharide From Tremella fuciformis Alleviated High-Fat Diet-Induced Obesity by Promoting AMPK/PINK1/PRKN-Mediated Mitophagy in Mice., PMID:39924795
HIV-1 gp120 Interactions with Nicotine Modulate Mitochondrial Network Properties and Amyloid Release in Microglia., PMID:39992414
Prohibitin2 knockdown decreases glioma malignant phenotypes and radio-resistance by inhibiting mitophagy., PMID:40029335
Emerging roles of prohibitins in cancer: an update., PMID:40057573
Identification of Prognostic Genes Related to Cell Senescence and Lipid Metabolism in Glioblastoma Based on Transcriptome and Single-Cell RNA-Seq Data., PMID:40076502
Stressed hepatocyte sustains alcohol-associated hepatitis progression by producing leukocyte cell-derived chemotaxin 2., PMID:40139745
Inhibition of PHB1/PHB2 suppresses atherosclerotic plaque formation by interrupting PI3K/AKT/mTOR signaling., PMID:40168274
Bisphosphonates Trigger Anti-Ageing Effects Across Multiple Cell Types and Protect Against Senescence., PMID:40196558
Acute rheumatic fever and Post-streptococcal reactive arthritis., PMID:40345912
Krüppel like factor 7 regulates mitochondrial dynamics balance in myocardial infarction., PMID:40346382
The effector protein Hcp1 of avian pathogenic Escherichia coli causes mitochondrial dysfunction by interacting with PHB2., PMID:40411919
Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance., PMID:40426179
Inhibiting CMTM4 reverses the immunosuppressive function of myeloid-derived suppressor cells and augments immunotherapy response in cervical cancer., PMID:40514067
For research use only. Not for human or drug use.
