Catalog No.
YHD88301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp356-Leu524
Predicted molecular weight
22.50 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P30304
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Dual specificity phosphatase Cdc25A, M-phase inducer phosphatase 1, CDC25A
Note
For research use only.
Silencing CDC25A inhibits the proliferation of liver cancer cells by downregulating IL‑6 in vitro and in vivo., PMID:31922225
STAT5-dependent regulation of CDC25A by miR-16 controls proliferation and differentiation in FLT3-ITD acute myeloid leukemia., PMID:32024878
Potential biomarkers screening to predict side effects of dexamethasone in different cancers., PMID:32048780
CircRNA hsa_circ_0004771 promotes esophageal squamous cell cancer progression via miR-339-5p/CDC25A axis., PMID:32050790
Albendazole negatively regulates keratinocyte proliferation., PMID:32236445
Genome-scale screening of deubiquitinase subfamily identifies USP3 as a stabilizer of Cdc25A regulating cell cycle in cancer., PMID:32415280
LINC00473 contributes to the radioresistance of esophageal squamous cell carcinoma by regulating microRNA‑497‑5p and cell division cycle 25A., PMID:32468021
Circulating Proteoglycan Endocan Mediates EGFR-Driven Progression of Non-Small Cell Lung Cancer., PMID:32561533
Comparison of the therapeutic effects of lobaplatin and carboplatin on retinoblastoma in vitro and in vivo., PMID:32582992
Coexpression Analysis of the EZH2 Gene Using The Cancer Genome Atlas and Oncomine Databases Identifies Coexpressed Genes Involved in Biological Networks in Breast Cancer, Glioblastoma, and Prostate Cancer., PMID:32595202
Standardized Saponin Extract from Baiye No.1 Tea (Camellia sinensis) Flowers Induced S Phase Cell Cycle Arrest and Apoptosis via AKT-MDM2-p53 Signaling Pathway in Ovarian Cancer Cells., PMID:32752095
The REGγ inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells., PMID:32764536
Targeting 14-3-3ε activates apoptotic signaling to prevent cutaneous squamous cell carcinoma., PMID:32816038
HAUSP stabilizes Cdc25A and protects cervical cancer cells from DNA damage response., PMID:32860838
LINC00662 contributes to the progression and the radioresistance of cervical cancer by regulating miR-497-5p and CDC25A., PMID:32869878
Epigallocatechin gallate induces chemopreventive effects on rats with diethylnitrosamine‑induced liver cancer via inhibition of cell division cycle 25A., PMID:33000276
[Expression of CDC25A in non-small cell lung cancer and its relationship with let-7 gene]., PMID:33243735
TTK, CDC25A, and ESPL1 as Prognostic Biomarkers for Endometrial Cancer., PMID:33282948
FBXW8 regulates G1 and S phases of cell cycle progression by restricting β-TrCP1 function., PMID:33742524
Hypericin-mediated photodynamic therapy inhibits growth of colorectal cancer cells via inducing S phase cell cycle arrest and apoptosis., PMID:33811836
Ubiquitin-Specific Protease 29 Regulates Cdc25A-Mediated Tumorigenesis., PMID:34071237
Activation of CDC25A phosphatase is limited by CDK2/cyclin A-mediated feedback inhibition., PMID:34156324
miR-199a-5p inhibits the proliferation of hepatocellular carcinoma cells by regulating CDC25A to induce cell cycle arrest., PMID:34314996
A novel CDC25A/DYRK2 regulatory switch modulates cell cycle and survival., PMID:34363019
Hsa_circ_0014879 regulates the radiosensitivity of esophageal squamous cell carcinoma through miR-519-3p/CDC25A axis., PMID:34407051
Cdc25A inhibits autophagy-mediated ferroptosis by upregulating ErbB2 through PKM2 dephosphorylation in cervical cancer cells., PMID:34743185
miR-34a-5p blocks cervical cancer growth and migration by downregulating CDC25A., PMID:34761581
Screening of pyroptosis-related genes influencing the therapeutic effect of dehydroabietic acid in liver cancer and construction of a survival nomogram., PMID:34800881
FDI-6 and olaparib synergistically inhibit the growth of pancreatic cancer by repressing BUB1, BRCA1 and CDC25A signaling pathways., PMID:34954029
MiR-99a-5p Constrains Epithelial-Mesenchymal Transition of Cervical Squamous Cell Carcinoma Via Targeting CDC25A/IL6., PMID:35532870
F-Box Protein 11 Suppresses Cell Proliferation and Aerobic Glycolysis in Glioblastomas by Mediating the Ubiquitin Degradation of Cdc25A., PMID:35582896
CircFNDC3B knockdown restrains the progression of oesophageal squamous cell carcinoma through miR-214-3p/CDC25A axis., PMID:36184488
Let-7c-5p Represses Cisplatin Resistance of Lung Adenocarcinoma Cells by Targeting CDC25A., PMID:36355336
SRSF10 stabilizes CDC25A by triggering exon 6 skipping to promote hepatocarcinogenesis., PMID:36539837
Small-Molecule Cdc25A Inhibitors Protect Neuronal Cells from Death Evoked by NGF Deprivation and 6-Hydroxydopamine., PMID:36942687
PLCε promotes the Warburg effect and tumorigenesis through AKT/GSK3β/Cdc25a in bladder cancer., PMID:37018449
CDC25A inhibition suppresses cell proliferation and induces G1/S‑phase cell cycle arrest in nasopharyngeal carcinoma., PMID:37052240
FOXK1 regulates malignant progression and radiosensitivity through direct transcriptional activation of CDC25A and CDK4 in esophageal squamous cell carcinoma., PMID:37173384
Mechanism of Exosomal LncRNA PART1 in Esophageal Cancer Angiogenesis by Targeting miR-302a-3p/CDC25A Axis., PMID:37386808
CircCCL22 Regulates CDC25A via Sponging miR-543 and Promotes Proliferation and Metastasis in Endometrial Cancer., PMID:37747673
Usf2 Deficiency Promotes Autophagy to Alleviate Cerebral Ischemia-Reperfusion Injury Through Suppressing YTHDF1-m6A-Mediated Cdc25A Translation., PMID:37914905
Regulatory mechanism of interaction between Y-box-binding protein 1 and heterogenous nuclear ribonucleoprotein K in cell division cycle 25a signal pathway and lung cancer metastasis., PMID:38279484
Yifei Sanjie formula alleviates lung cancer progression via regulating PRMT6-YBX1-CDC25A axis., PMID:38357781
The Development of CDC25A-Derived Phosphoseryl Peptides That Bind 14-3-3ε with High Affinities., PMID:38732131
Inhibition of Melanoma Cell Growth by Salvianolic Acid A through CHK2-CDC25A Pathway Modulation., PMID:38940031
Cryo-EM structure of the CDK2-cyclin A-CDC25A complex., PMID:39122719
m6A modification enhances the stability of CDC25A promotes tumorigenicity of esophagogastric junction adenocarcinoma via cell cycle., PMID:39247830
Cdc25A phosphatase is activated and mediates neuronal cell death by PUMA via pRb/E2F1 pathway in a model of Parkinson's disease., PMID:39305937
CDC25A inhibition sensitizes melanoma cells to doxorubicin and NK cell therapy., PMID:40216745
MicroRNA-34a-5p induces cell cycle arrest and leads to spermatogenesis failure by targeting CDC25A., PMID:40418379
For research use only. Not for human or drug use.
