Catalog No.
YHK40101
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg1012-Arg1335
Predicted molecular weight
38.66 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8N122
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
KIAA1303, Raptor, RAPTOR, RPTOR, Regulatory-associated protein of mTOR, p150 target of rapamycin (TOR)-scaffold protein
Note
For research use only.
Raptor mediates the selective inhibitory effect of cardamonin on RRAGC-mutant B cell lymphoma., PMID:37749558
Direct regulation of FNIP1 and FNIP2 by MEF2 sustains MTORC1 activation and tumor progression in pancreatic cancer., PMID:37772772
Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide., PMID:37930356
Targeting DNA methylation in diabetic kidney disease: A new perspective., PMID:37949210
Molecular mechanism of microRNA-mediated hypoglycemic effect of whole grain highland barley., PMID:38007158
MALAT1 DEREPRESSES MIR-433-3P-MEDIATED RPTOR SUPPRESSION TO IMPAIR AUTOPHAGY AND DRIVE PYROPTOSIS IN ENDOTOXEMIA., PMID:38010109
The Mechanistic Target of Rapamycin Complex 1 Pathway Contributes to the Anti-Tumor Effect of Granulocyte-Macrophage-Colony-Stimulating Factor-Producing T Helper Cells in Mouse Colorectal Cancer., PMID:38050895
RPTOR mutation: a novel predictor of efficacious immunotherapy in melanoma., PMID:38071684
Transcriptome analysis of skeletal muscle in dermatomyositis, polymyositis, and dysferlinopathy, using a bioinformatics approach., PMID:38125829
RPTOR blockade suppresses brain metastases of NSCLC by interfering the ceramide metabolism via hijacking YY1 binding., PMID:38163890
A novel MTORC2-AKT-ROS axis triggers mitofission and mitophagy-associated execution of colorectal cancer cells upon drug-induced activation of mutant KRAS., PMID:38261660
p300 nucleocytoplasmic shuttling underlies mTORC1 hyperactivation in Hutchinson-Gilford progeria syndrome., PMID:38267537
Selective disruption of mTORC1 and mTORC2 in VTA astrocytes induces depression and anxiety-like behaviors in mice., PMID:38307148
mTOR Regulates Mineralocorticoid Receptor Transcriptional Activity by ULK1-Dependent and -Independent Mechanisms., PMID:38325289
Role of Raptor Gene Variants in Hypertension: Influence on Blood Pressure Independent of Salt Intake in White Population., PMID:38497230
Zebrafish raptor mutation inhibits the activity of mTORC1, inducing craniofacial defects due to autophagy-induced neural crest cell death., PMID:38512806
Reduced mTORC1-signaling in progenitor cells leads to retinal lamination deficits., PMID:38546215
Synergistic hyperactivation of both mTORC1 and mTORC2 underlies the neural abnormalities of PTEN-deficient human neurons and cortical organoids., PMID:38700984
Role of endothelial Raptor in abnormal arteriogenesis after lower limb ischaemia in type 2 diabetes., PMID:38722901
A role of dentate gyrus mechanistic target of rapamycin activation in epileptogenesis in a mouse model of posttraumatic epilepsy., PMID:38761065
mTORC1 Signaling in Brain Endothelial Progenitors Contributes to CCM Pathogenesis., PMID:38957991
Resistance training boosts lactate transporters and synaptic proteins in insulin-resistance mice., PMID:39082040
Genomic insights into mRNA COVID-19 vaccines efficacy: Linking genetic polymorphisms to waning immunity., PMID:39254005
Paeoniflorin inhibits PRAS40 interaction with Raptor to activate mTORC1 to reverse excessive autophagy in airway epithelial cells for asthma., PMID:39276538
Mechanistic target of rapamycin (mTOR) pathway in Sertoli cells regulates age-dependent changes in sperm DNA methylation., PMID:39283662
Axin1 regulates tooth root development by inhibiting AKT1-mTORC1 activation and Shh translation in Hertwig's epithelial root sheath., PMID:39344774
USP9X-mediated deubiquitination of Raptor contributes to autophagy impairment and memory deficits in P301S mice., PMID:39449082
ALYREF recruits ELAVL1 to promote colorectal tumorigenesis via facilitating RNA m5C recognition and nuclear export., PMID:39455812
TSC2-mTORC1 axis regulates morphogenesis and neurological function of Gli1+ adult-born dentate granule cells., PMID:39602293
Effect of Zinc on Blood Biochemical and mTOR Gene Expression in Rats with Polycystic Ovarian., PMID:39614065
USP19 potentiates autophagic cell death via inhibiting mTOR pathway through deubiquitinating NEK9 in pancreatic cancer., PMID:39627360
Genetic and pharmacological targeting of mTORC1 in mouse models of arteriovenous malformation expose non-cell autonomous signalling in HHT., PMID:39661206
Gene-Silencing Therapeutic Approaches Targeting PI3K/Akt/mTOR Signaling in Degenerative Intervertebral Disk Cells: An In Vitro Comparative Study Between RNA Interference and CRISPR-Cas9., PMID:39682777
A Binary siRNA-Loaded Tetrahedral DNA Nanobox for Synergetic Anti-Aging Therapy., PMID:39690794
The steroid hormone 20-hydroxyecdysone inhibits RAPTOR expression by repressing Hox gene transcription to induce autophagy., PMID:39706274
mTOR Ser1261 is an AMPK-dependent phosphosite in mouse and human skeletal muscle not required for mTORC2 activity., PMID:39835637
Proteome differences of dental stem cells between permanent and deciduous teeth by data-independent acquisition proteomics., PMID:39886483
Buddleoside alleviates nonalcoholic steatohepatitis by targeting the AMPK-TFEB signaling pathway., PMID:39936600
Transcriptome analysis of 3D4/21 cells expressing CSFV NS4B., PMID:39967738
Neuroglobin regulates autophagy through mTORC1/RAPTOR/ULK-1 pathway in human neuroblastoma cells., PMID:40038411
Intrinsic differences in mTOR activity mediates lineage-specific responses to cyclophosphamide in mouse and human granulosa cells., PMID:40069773
Direct sensing of dietary ω-6 linoleic acid through FABP5-mTORC1 signaling., PMID:40080571
Neural stimulation suppresses mTORC1-mediated protein synthesis in skeletal muscle., PMID:40173236
Increased fatty acid delivery by tumor endothelium promotes metastatic outgrowth., PMID:40198126
POLR1D, a shared subunit of RNA polymerase I and III, modulates mTORC1 activity., PMID:40222657
The Effect of Valine on the Synthesis of α-Casein in MAC-T Cells and the Expression and Phosphorylation of Genes Related to the mTOR Signaling Pathway., PMID:40243924
Cardamonin suppresses mTORC1/SREBP1 through reducing Raptor and inhibits de novo lipogenesis in ovarian cancer., PMID:40315213
Biased regulation of protein synthesis and hypoxic death by a conditional raptor mutation., PMID:40339571
Rapamycin exerts neuroprotective effects by inhibiting FKBP12 instead of mTORC1 in the mouse model of Parkinson's disease., PMID:40345576
mTOR promotes the formation and growth of tertiary lymphoid tissues in the kidney., PMID:40496859
For research use only. Not for human or drug use.
