Catalog No.
YHD02701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Glu36-Asn350
Predicted molecular weight
36.43 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P13995
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NMDMC, MTHFD2, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Note
For research use only.
Binding Modes of Xanthine-Derived Selective Allosteric Site Inhibitors of MTHFD2., PMID:37129313
MTHFD2 reprograms macrophage polarization by inhibiting PTEN., PMID:37149861
Mitochondrial folate pathway regulates myofibroblast differentiation and silica-induced pulmonary fibrosis., PMID:37280614
Bioinformatics and system biology approach to identify potential common pathogenesis for COVID-19 infection and osteoarthritis., PMID:37291167
Clinicopathological significance of unraveling mitochondrial pathway alterations in non-small-cell lung cancer., PMID:37310411
MTHFD2 promotes PD-L1 expression via activation of the JAK/STAT signalling pathway in bladder cancer., PMID:37480214
SNHG3/hsa-miR-455-5p Axis-mediated High Expression of MTHFD2 Correlates with Tumor Immune Infiltration and Endometrial Carcinoma Progression., PMID:37484807
Association of Maternal Folate Intake and Offspring MTHFD1 and MTHFD2 Genes with Congenital Heart Disease., PMID:37630697
Consensus cluster analysis of apoptosis-related genes in patients with osteoarthritis and their correlation with immune cell infiltration., PMID:37860011
Targeting allosteric binding site in methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) to identify natural product inhibitors via structure-based computational approach., PMID:37872243
Metabolic disturbance and transcriptomic changes induced by methyl triclosan in human hepatocyte L02 cells., PMID:37915488
Mitochondrial One-Carbon Metabolism is Required for TGF-β-Induced Glycine Synthesis and Collagen Protein Production., PMID:37986788
A Randomized Phase III Study of Arfolitixorin versus Leucovorin with 5-Fluorouracil, Oxaliplatin, and Bevacizumab for First-Line Treatment of Metastatic Colorectal Cancer: The AGENT Trial., PMID:38059497
Downregulation of MTHFD2 Inhibits Proliferation and Enhances Chemosensitivity in Hepatocellular Carcinoma via PI3K/AKT Pathway., PMID:38287824
MHY1485 promotes adriamycin sensitivity in HepG2 cells by inhibiting autophagy., PMID:38306005
Prognosis prediction and risk stratification of breast cancer patients based on a mitochondria-related gene signature., PMID:38310106
Metabolic subtypes and immune landscapes in esophageal squamous cell carcinoma: prognostic implications and potential for personalized therapies., PMID:38373930
Induction of MTHFD2 in Macrophages Inhibits Reactive Oxygen Species-mediated NF-κB Activation and Protects against Inflammatory Responses., PMID:38407485
Implications of MTHFD2 expression in renal cell carcinoma aggressiveness., PMID:38422037
CircUBE3A(2,3,4,5) promotes adenylate-uridylate-rich binding factor 1 nuclear translocation to suppress prostate cancer metastasis., PMID:38423246
Interference with MTHFD2 induces ferroptosis in ovarian cancer cells through ERK signaling to suppress tumor malignant progression., PMID:38488992
The one-carbon metabolic enzyme MTHFD2 promotes resection and homologous recombination after ionizing radiation., PMID:38533616
Loss of the histone chaperone UNC-85/ASF1 inhibits the epigenome-mediated longevity and modulates the activity of one-carbon metabolism., PMID:38608859
MTHFD2-mediated redox homeostasis promotes gastric cancer progression under hypoxic conditions., PMID:38723197
Characterizing mitochondrial features in osteoarthritis through integrative multi-omics and machine learning analysis., PMID:39026663
Metabolic determinants of germinal center B cell formation and responses., PMID:39060389
Congenital Heart Disease and Genetic Changes in Folate/Methionine Cycles., PMID:39062651
Exploring the Anticancer Potential of Furanpydone A: A Computational Study on its Inhibition of MTHFD2 Across Diverse Cancer Cell Lines., PMID:39110299
DUSP6 protein action and related hub genes prevention of sepsis-induced lung injury were screened by WGCNA and Venn., PMID:39197622
EP300-mediated H3 acetylation elevates MTHFD2 expression to reduce mitochondrial dysfunction in lipopolysaccharide-induced tubular epithelial cells., PMID:39230047
Interaction Between the PERK/ATF4 Branch of the Endoplasmic Reticulum Stress and Mitochondrial One-Carbon Metabolism Regulates Neuronal Survival After Intracerebral Hemorrhage., PMID:39247810
Selectivity analysis of diaminopyrimidine-based inhibitors of MTHFD1, MTHFD2 and MTHFD2L., PMID:39256448
Engineered Biomimetic Nanovesicles Synergistically Remodel Folate-Nucleotide and γ-Aminobutyric Acid Metabolism to Overcome Sunitinib-Resistant Renal Cell Carcinoma., PMID:39329191
Nuclear localization of MTHFD2 is required for correct mitosis progression., PMID:39532843
Impact of MTHFD2 Expression in Bladder/Breast Cancer and Screening of Its Potential Inhibitor., PMID:39524662
Development of Potent and Selective Inhibitors of Methylenetetrahydrofolate Dehydrogenase 2 for Targeting Acute Myeloid Leukemia: SAR, Structural Insights, and Biological Characterization., PMID:39591507
Compound Bacillus improves eggshell quality and egg metabolites of hens by promoting the metabolism balance of calcium and phosphorus and uterine cell proliferation., PMID:39640545
Prognostic assessment of early-stage liver cirrhosis induced by HCV using an integrated model of CX3CR1-associated immune infiltration genes., PMID:39800763
MTHFD2 Enhances cMYC O-GlcNAcylation to Promote Sunitinib Resistance in Renal Cell Carcinoma., PMID:39804969
MTHFD2 promotes breast cancer cell proliferation through IFRD1 RNA m6A methylation-mediated HDAC3/p53/mTOR pathway., PMID:39832202
MTHFD2 stabilizes LOX expression through RNA methylation modification to promote sepsis-induced acute kidney injury progression., PMID:40009304
MTHFD2 promotes osteoclastogenesis and bone loss in rheumatoid arthritis by enhancing CKMT1-mediated oxidative phosphorylation., PMID:40016725
MTHFD2 promotes esophageal squamous cell carcinoma progression via m6A modification‑mediated upregulation and modulation of the PEBP1‑RAF1 interaction., PMID:40052596
CAPRIN1/TYMS/MTHFD2 axis promotes EMT process in nasopharyngeal carcinoma development., PMID:40246062
MTHFD2: A metabolic checkpoint altering trophoblast invasion and migration by remodeling folate-nucleotide metabolism in recurrent spontaneous abortion., PMID:40250694
MTHFD2 marks pemetrexed resistance in pulmonary adenocarcinoma with EGFR wild type., PMID:40253662
Targeting MTHFD2 alters metabolic homeostasis and synergizes with bortezomib to inhibit multiple myeloma., PMID:40280919
Hit to lead optimization of isopentenyl chalcones as novel MTHFD2 inhibitors for cancer treatment: design, synthesis, in-vitro, in-vivo and in-silico studies., PMID:40334504
MTHFD2: A significant mitochondrial metabolic enzyme and a novel target for anticancer therapy., PMID:40348077
BRD9 functions as an HIV-1 latency regulatory factor., PMID:40402245
For research use only. Not for human or drug use.
