Catalog No.
YHG42501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Lys120-Lys320
Predicted molecular weight
24.71 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13155
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Protein JTV-1, Multisynthase complex auxiliary component p38, AIMP2, JTV1, Aminoacyl tRNA synthase complex-interacting multifunctional protein 2
Response to anti-angiogenic therapy is affected by AIMP protein family activity in glioblastoma and lower-grade gliomas., PMID:40161601
An Integrative Computational Approach for the Identification of C-Abl Kinase Inhibitors from Anti-Parkinson Plant-Derived Bioactive., PMID:39812069
The Dual Role of Survival Genes in Neurons and Cancer Cells: a Strategic Clinical Application of DX2 in Neurodegenerative Diseases and Cancer., PMID:39711064
An extensive in silico analysis of missense mutations of the human AIMP2 gene., PMID:39640834
Dual inhibition of aminoacyl-tRNA synthetase interacting multifunctional protein-2 and α-synuclein by steroid derivative is neuroprotective in Parkinson's model., PMID:39569370
Assembly of the Human Multi-tRNA Synthetase Complex Through Leucine Zipper Motifs., PMID:39542129
AIMP2 accumulation in brain leads to cognitive deficits and blood secretion in Parkinson's disease., PMID:39390613
The therapeutic effect of DX2 inhibition in nicotine-induced lung cancer progression., PMID:39351074
Chemical induction of the interaction between AIMP2-DX2 and Siah1 to enhance ubiquitination., PMID:39260366
MTCH2 promotes the malignant progression of ovarian cancer through the upregulation of AIMP2 expression levels, mitochondrial dysfunction and by mediating energy metabolism., PMID:39185493
Identification of the proteolytic signature in CVB3-infected cells., PMID:38953667
AIMP2 restricts EV71 replication by recruiting SMURF2 to promote the degradation of 3D polymerase., PMID:38945214
Identification and structure of AIMP2-DX2 for therapeutic perspectives., PMID:38835119
Pan-cancer Analysis Identifies AIMP2 as a Potential Biomarker for Breast Cancer., PMID:38235352
Metal-enhanced fluorescence biosensor integrated in capillary flow-driven microfluidic cartridge for highly sensitive immunoassays., PMID:38176256
Bi-directional regulation of AIMP2 and its splice variant on PARP-1-dependent neuronal cell death; Therapeutic implication for Parkinson's disease., PMID:38172953
Hexokinase 2 confers radio-resistance in hepatocellular carcinoma by promoting autophagy-dependent degradation of AIMP2., PMID:37524692
The allelic regulation of tumor suppressor ADARB2 in papillary thyroid carcinoma., PMID:36305508
Synthesis and discovery of the first potent proteolysis targeting chimaera (PROTAC) degrader of AIMP2-DX2 as a lung cancer drug., PMID:36305287
Pharmacological inhibition of AIMP2 aggregation attenuates α-synuclein aggregation and toxicity in Parkinson's disease., PMID:36283223
The Absence of Parkin Does Not Promote Dopamine or Mitochondrial Dysfunction in PolgAD257A/D257A Mitochondrial Mutator Mice., PMID:36280265
Anti-apoptotic Splicing Variant of AIMP2 Recover Mutant SOD1-Induced Neuronal Cell Death., PMID:36242734
Discovery of benzodioxane analogues as lead candidates of AIMP2-DX2 inhibitors., PMID:35842206
AIMP2-DX2 provides therapeutic interface to control KRAS-driven tumorigenesis., PMID:35546148
Discovery of two distinct aminoacyl-tRNA synthetase complexes anchored to the Plasmodium surface tRNA import protein., PMID:35487244
The RNA editing enzyme ADAR modulated by the rs1127317 genetic variant diminishes EGFR-TKIs efficiency in advanced lung adenocarcinoma., PMID:35202641
Case Report: Mutation in AIMP2/P38, the Scaffold for the Multi-Trna Synthetase Complex, and Association With Progressive Neurodevelopmental Disorders., PMID:35140751
Human lysyl-tRNA synthetase evolves a dynamic structure that can be stabilized by forming complex., PMID:35133502
The Identification of Prognostic and Metastatic Alternative Splicing in Skin Cutaneous Melanoma., PMID:34986671
Comparative proteomic profiling reveals a pathogenic role for the O-GlcNAcylated AIMP2-PARP1 complex in aging-related hepatic steatosis in mice., PMID:34817071
Is Methionyl-tRNA Synthetase Applicable as a Diagnostic Marker for Lung Cancer in Bronchial Ultrasound-Guided Brushing Cells?, PMID:34679529
Knockdown of Golgi Stress-Responsive Caspase-2 Ameliorates HLD17-Associated AIMP2 Mutant-Mediated Inhibition of Oligodendroglial Cell Morphological Differentiation., PMID:34523057
Allosteric Inhibition of the Tumor-Promoting Interaction Between Exon 2-Depleted Splice Variant of Aminoacyl-Transfer RNA Synthetase-Interacting Multifunctional Protein 2 and Heat Shock Protein 70., PMID:34503993
Methionyl-tRNA synthetase and aminoacyl-tRNA synthetases interacting multi-functional protein-lacking exon 2 as potential diagnostic biomarkers for lung cancer., PMID:34249450
Copy number alteration profiling facilitates differential diagnosis between ossifying fibroma and fibrous dysplasia of the jaws., PMID:34188021
Lewy body-associated proteins: victims, instigators, or innocent bystanders? The case of AIMP2 and alpha-synuclein., PMID:34102275
Amyloid-like oligomerization of AIMP2 contributes to α-synuclein interaction and Lewy-like inclusion., PMID:33177178
Single-cell analysis of AIMP2 splice variants informs on drug sensitivity and prognosis in hematologic cancer., PMID:33128014
Roles of aminoacyl-tRNA synthetase-interacting multi-functional proteins in physiology and cancer., PMID:32709848
Anticancer Activity of Pyrimethamine via Ubiquitin Mediated Degradation of AIMP2-DX2., PMID:32549310
An Isoform of the Oncogenic Splice Variant AIMP2-DX2 Detected by a Novel Monoclonal Antibody., PMID:32471182
Structural insight into the interaction between p53 TAD1 and AIMP2-DX2 by NMR., PMID:32448505
Synthesis and Structure-Activity Relationships of Arylsulfonamides as AIMP2-DX2 Inhibitors for the Development of a Novel Anticancer Therapy., PMID:32315177
2-Aminophenylpyrimidines as Novel Inhibitors of Aminoacyl-tRNA Synthetase Interacting Multifunctional Protein 2 (AIMP2)-DX2 for Lung Cancer Treatment., PMID:32208684
Crystal structures of the two domains that constitute the Plasmodium vivax p43 protein., PMID:32038044
Deubiquitinase USP29 Governs MYBBP1A in the Brains of Parkinson's Disease Patients., PMID:31878357
Targeting the interaction of AIMP2-DX2 with HSP70 suppresses cancer development., PMID:31792442
The DRS-AIMP2-EPRS subcomplex acts as a pivot in the multi-tRNA synthetase complex., PMID:31576228
Symmetric Assembly of a Decameric Subcomplex in Human Multi-tRNA Synthetase Complex Via Interactions between Glutathione Transferase-Homology Domains and Aspartyl-tRNA Synthetase., PMID:31473157
Quantitative analysis of nasal transcripts reveals potential biomarkers for Parkinson's disease., PMID:31366968
For research use only. Not for human or drug use.
