Catalog No.
YHA95001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn35-Asn255
Predicted molecular weight
27.75 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O60568
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
LH3, Lysyl hydroxylase 3, Procollagen galactosyltransferase, Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3, Galactosylhydroxylysine-glucosyltransferase, PLOD3, Procollagen glucosyltransferase
Note
For research use only.
Overexpression of LH3 reduces the incidence of hypertensive intracerebral hemorrhage in mice., PMID:30516406
Lysyl hydroxylase 3 increases collagen deposition and promotes pulmonary fibrosis by activating TGFβ1/Smad3 and Wnt/β-catenin pathways., PMID:32190155
SiMPLOD, a Structure-Integrated Database of Collagen Lysyl Hydroxylase (LH/PLOD) Enzyme Variants., PMID:30721533
PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathway., PMID:30770789
Pathogenic variants in PLOD3 result in a Stickler syndrome-like connective tissue disorder with vascular complications., PMID:31129566
Identification and characterization of collagen-like glycosylation and hydroxylation of CCN1., PMID:31317175
Defining Protein Pattern Differences Among Molecular Subtypes of Diffuse Gliomas Using Mass Spectrometry., PMID:31353322
Lysyl hydroxylase 3 is required for normal lens capsule formation and maintenance of lens epithelium integrity and fate., PMID:31669351
Overexpressing PLOD family genes predict poor prognosis in gastric cancer., PMID:31892979
Identification of differentially expressed methylated genes in melanoma versus nevi using bioinformatics methods., PMID:32547879
Knockdown of PLOD3 suppresses the malignant progression of renal cell carcinoma via reducing TWIST1 expression., PMID:32585183
Prediction of 3D Protein Structure Based on The Mutation of AKAP3 and PLOD3 Genes in The Case of Non-Obstructive Azoospermia., PMID:32681621
Identification of PLOD Family Genes as Novel Prognostic Biomarkers for Hepatocellular Carcinoma., PMID:33014843
PLOD1 Is a Prognostic Biomarker and Mediator of Proliferation and Invasion in Osteosarcoma., PMID:33134376
PLODs are overexpressed in ovarian cancer and are associated with gap junctions via connexin 43., PMID:33483598
COLGALT2 is overexpressed in ovarian cancer and interacts with PLOD3., PMID:33783989
Polypeptide N-acetylgalactosaminyltransferase 18 retains in endoplasmic reticulum depending on its luminal regions interacting with ER resident UGGT1, PLOD3 and LPCAT1., PMID:33909026
Involvement of LH3 and GLT25D1 for glucosyl-galactosyl-hydroxylation on non-collagen-like domain of FGL1., PMID:33984770
A five-gene signature is a prognostic biomarker in pan-cancer and related with immunologically associated extracellular matrix., PMID:34121340
PLOD3 Is Associated with Immune Cell Infiltration and Genomic Instability in Colon Adenocarcinoma., PMID:34239923
Characterization of a cancer-associated Epstein-Barr virus EBNA1 variant reveals a novel interaction with PLOD1 and PLOD3., PMID:34304093
New mechanistic insights to PLOD1-mediated human vascular disease., PMID:34400365
A Human Pan-Cancer System Analysis of Procollagen-Lysine, 2-Oxoglutarate 5-Dioxygenase 3 (PLOD3)., PMID:34576068
Exploration of the typical features of tubulovillous adenoma using in-depth quantitative proteomics analysis., PMID:34585630
Integrated Profiling Identifies PLOD3 as a Potential Prognostic and Immunotherapy Relevant Biomarker in Colorectal Cancer., PMID:34646265
PLOD3 regulates the expression of YAP1 to affect the progression of non-small cell lung cancer via the PKCδ/CDK1/LIMD1 signaling pathway., PMID:35039611
Bioinformatic analysis of PLOD family member expression and prognostic value in non-small cell lung cancer., PMID:35116582
Clinical Prognostic Value of the PLOD Gene Family in Lung Adenocarcinoma., PMID:35265665
Overexpressing PLOD Family Genes Predict Poor Prognosis in Pancreatic Cancer., PMID:35330878
Pathomechanisms of epidermolysis bullosa: Beyond structural proteins., PMID:35504439
Multicenter phase II trial of Camrelizumab combined with Apatinib and Eribulin in heavily pretreated patients with advanced triple-negative breast cancer., PMID:35641481
PLOD3 contributes to HER-2 therapy resistance in gastric cancer through FoxO3/Survivin pathway., PMID:35835735
Analysis of genetic profiling, pathomics signature, and prognostic features of primary lymphoepithelioma-like carcinoma of the renal pelvis., PMID:36052737
Transcriptome analysis of a dog model of congestive heart failure shows that collagen-related 2-oxoglutarate-dependent dioxygenases contribute to heart failure., PMID:36581661
Urinary protein biomarkers based on LC-MS/MS analysis to discriminate vascular dementia from Alzheimer's disease in Han Chinese population., PMID:36761180
Comprehensive Analysis of the Expression, Prognosis, and Biological Significance of PLOD Family in Bladder Cancer., PMID:36872941
Identification and validation of an ECM organization-related gene signature as a prognostic biomarker and therapeutic target for glioma patients., PMID:37301776
Identification of Regulatory Molecular "Hot Spots" for LH/PLOD Collagen Glycosyltransferase Activity., PMID:37446392
PLOD3 facilitated T cell activation in the colorectal tumor microenvironment and liver metastasis by the TNF-α/ NF-κB pathway., PMID:38184566
Systematic characterization of the expression, prognosis and immune characteristics of PLOD family genes in breast cancer., PMID:39068670
Identification of Variants of Uncertain Significance in the Genes Associated with Thoracic Aortic Disease in Russian Patients with Nonsyndromic Sporadic Subtypes of the Disorder., PMID:39125885
Integrative analysis regarding the correlation between collagen-related genes and prostate cancer., PMID:39174928
Hypoxia-driven M2-polarized macrophages facilitate the epithelial-mesenchymal transition of glioblastoma via extracellular vesicles., PMID:39431006
RBM15 increase tumor-infiltrating CD4+ T cell in ESCC via modulating of PLOD3., PMID:39659928
To investigate the tumor promotion role of PLOD3 in colorectal cancer and its potential as a prognostic biomarker and therapeutic target., PMID:39948137
The structural basis for the human procollagen lysine hydroxylation and dual-glycosylation., PMID:40069201
Hypomethylation induced overexpression of PLOD3 facilitates colorectal cancer progression through TM9SF4-mediated autophagy., PMID:40133271
Lysyl hydroxylase 2 glucosylates collagen VI to drive lung cancer progression., PMID:40166934
Expanding the Clinical Spectrum of BCARD Syndrome Caused by Novel Biallelic Variants in the PLOD3 Gene., PMID:40289369
Mass spectrometry reveals age-dependent collagen decline in murine atria., PMID:40295212
For research use only. Not for human or drug use.
