Catalog No.
YHH33601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser10-Met411
Predicted molecular weight
47.69 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q16654
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PDHK4, Pyruvate dehydrogenase kinase isoform 4, PDK4, [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial
Note
For research use only.
Ferroptosis-Related Genes in IgA Nephropathy: Screening for Potential Targets of the Mechanism., PMID:39171207
Dichloroacetate Prevents Sepsis Associated Encephalopathy by Inhibiting Microglia Pyroptosis through PDK4/NLRP3., PMID:39177920
Effective strategies alleviate mitochondrial toxicity of perfluorooctanoic acid: Modification of functional head group and inhibition of toxic target., PMID:39236541
Chronic Corticosterone Treatment Decreases Extracellular pH and Increases Lactate Release via PDK4 Upregulation in Cultured Astrocytes., PMID:39313390
Molecular mechanisms of ferroptosis in renal ischemia-reperfusion injury Investigated via bioinformatics analysis and animal experiments., PMID:39324174
Afterload-induced Decreases in Fatty Acid Oxidation Develop Independently of Increased Glucose Utilization., PMID:39345412
Responses to Exercise with Low Carbohydrate Availability on Muscle Glycogen and Cell Signaling: A Systematic Review and Meta-analysis., PMID:39352665
Mitochondrial-related genes as prognostic and metastatic markers in breast cancer: insights from comprehensive analysis and clinical models., PMID:39380996
Shaoyao decoction alleviates DSS-induced colitis by inhibiting IL-17a-mediated polarization of M1 macrophages., PMID:39427735
PFOA/PFOS Facilitated Intestinal Fatty Acid Absorption by Activating the PPARα Pathway: Insights from Organoids Model., PMID:39474103
Estrogen Regulates Mitochondrial Activity Through Inducing Brain-Derived Neurotrophic Factor Expression in Skeletal Muscle., PMID:39530291
Subcellular mass spectrometric detection unveils hyperglycemic memory in the diabetic heart., PMID:39539089
GPR30 Selective Agonist G1 Exhibits Antiobesity Effects and Promotes Insulin Resistance and Gluconeogenesis in Postmenopausal Mice Fed a High-Fat Diet., PMID:39554996
Transcriptome analysis of jejunal mucosal tissue in breeder hens exposed to acute heat stress., PMID:39561558
Multi-omics insights into the pathogenesis of diabetic cardiomyopathy: epigenetic and metabolic profiles., PMID:39623870
An enzyme-mimicking reactive oxygen species scavenger targeting oxidative stress-inflammation cycle ameliorates IR-AKI by inhibiting pyruvate dehydrogenase kinase 4., PMID:39659578
Eplerenone, a mineralocorticoid receptor inhibitor, reduces cirrhosis associated changes of hepatocyte glucose and lipid metabolism., PMID:39707386
Atractylodin alleviates polycystic ovary syndrome by inhibiting granule cells ferroptosis through pyruvate dehydrogenase kinase 4-mediated JAK-STAT3 pathway., PMID:39724732
Regulation of lactate accumulation in bovine mammary epithelial cells by LPS-induced HIF-1α/MCT1 pathway., PMID:39725042
Salvianic acid A ameliorates atherosclerosis through metabolic-dependent anti-EndMT pathway and repression of TGF-β/ALK5 signaling., PMID:39740380
Effects of seven days' fasting on physical performance and metabolic adaptation during exercise in humans., PMID:39747857
Validation and the role of PDK4 relevant to ferroptosis in degenerative lumbar disc disease., PMID:39794775
Differential gene expression analysis and machine learning identified structural, TFs, cytokine and glycoproteins, including SOX2, TOP2A, SPP1, COL1A1, and TIMP1 as potential drivers of lung cancer., PMID:39888730
Omega-3 polyunsaturated fatty acids modify glucose metabolism in THP-1 monocytes., PMID:39899814
Systems Biology Approach to Unraveling Transcriptomic Mechanisms of Ganfule Capsules in Ameliorating Nonalcoholic Fatty Liver Disease., PMID:39917919
Distinct Impact of Doxorubicin on Skeletal Muscle and Fat Metabolism in Mice: Without Dexrazoxane Effect., PMID:39940943
FGF21 protects against HFpEF by improving cardiac mitochondrial bioenergetics in mice., PMID:39955281
Identification of genes involved in energy metabolism in preeclampsia and discovery of early biomarkers., PMID:39967661
Identification and functional analysis of energy metabolism and pyroptosis-related genes in diabetic nephropathy., PMID:39995931
Reducing PDK4 level constitutes a pivotal mechanism for glucocorticoids to impede osteoblastic differentiation through the enhancement of ferroptosis in mesenchymal stem cells., PMID:40001240
Association of the TTN, PDK4, and RNF207 mutations with dilated cardiomyopathy in Dobermanns from the United Kingdom., PMID:40080479
Reconstituted High-Density Lipoproteins Rescue Diabetes-Impaired Endothelial Cell Metabolic Reprograming and Angiogenic Responses to Hypoxia., PMID:40109261
EGR2 promotes liver cancer metastasis by enhancing IL-8 expression through transcription regulation of PDK4 in M2 macrophages., PMID:40139095
Investigating the function and targeting of MET protein as an oncogene kinase in pancreatic ductal adenocarcinoma: A microarray data integration., PMID:40161938
Development of 2- and 3-prenylated quinolines and tetrahydroquinolines with PPAR activity: From hit to lead and a novel pan-PPAR agonist as a potential candidate for metabolic syndrome., PMID:40215945
Cardiac PDK4 promotes neutrophilic PFKL methylation and drives the innate immune response in diabetic myocardial infarction., PMID:40222696
Elevated cortisol concentration in preterm sheep fetuses impacts heart development., PMID:40296367
PDK4 expression and tumor aggressiveness in prostate cancer., PMID:40312902
Kallistatin Improves Lipid Metabolism and Alleviates Cardiac Hypertrophy via the SIRT1/PPAR Pathway: An Experimental Study., PMID:40320871
Fatty acid metabolism suppresses neonatal cardiomyocyte proliferation by increasing PDK4 and HMGCS2 expression through PPARδ., PMID:40338840
Inhibitory role of arecaidine on PPARγ signaling in oral mucosa: Mechanistic insights from transcriptome and experimental analysis., PMID:40339757
Renometabolic disorder in experimental rat model of polycystic ovarian syndrome is reversed by acetate-mediated inhibition of pyruvate dehydrogenase kinase 4., PMID:40361039
In Vitro Embryo Culture Impacts Heart Mitochondria in Male Adolescent Sheep., PMID:40407686
Mechanism Analysis of Zuogui and Yougui Pills on Diabetic Nephropathy Through Transcriptional Regulatory Networks of HIF1A and PPARA., PMID:40417738
Lipid exposure leads to metabolic dysfunction in fetal sheep cardiomyocytes., PMID:40420618
Oral Sulforaphane Intervention Protects Against Diabetic Cardiomyopathy in db/db Mice: Focus on Cardiac Lipotoxicity and Substrate Metabolism., PMID:40427484
Treatment with crocin attenuates cardiac metabolic disturbances and subsequent inflammation in streptozotocin-induced diabetes., PMID:40461763
Mult-omics analysis reveals the lipid-lowering effects of sea buckthorn and milk thistle solid beverage in hyperlipidemic rats., PMID:40472616
Mechanisms of aristolochic acid I Hepatotoxicity: Central role of PDK4-Induced mitochondrial dysfunction and hepatic inflammation., PMID:40480416
Targeting HDAC3 Suppresses Ferroptosis and Demyelination in White Matter Injury by Restoring PDK4-Mediated Iron Homeostasis., PMID:40485011
For research use only. Not for human or drug use.
