Catalog No.
YHG54301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Thr351
Predicted molecular weight
42.90 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q13464
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Renal carcinoma antigen NY-REN-35, p160 ROCK-1, p160ROCK, Rho-associated protein kinase 1, Rho-associated, coiled-coil-containing protein kinase I, Rho-associated, coiled-coil-containing protein kinase 1, ROCK-I, ROCK1
Note
For research use only.
Unraveling the protein kinase C/NDRG1 signaling network in breast cancer., PMID:39736699
N6-methyladenosine (m6A) RNA methylation of LncRNA LINC01214 accelerates the progression of non-small cell lung cancer (NSCLC) by targeting miR-195-5p/ROCK1 axis., PMID:39744313
Rnd3 protects against doxorubicin-induced cardiotoxicity through inhibition of PANoptosis in a Rock1/Drp1/mitochondrial fission-dependent manner., PMID:39755713
Isoform-selective and non-selective rho-kinase inhibitors do not affect collagenase-induced intracerebral hemorrhage outcomes in mice: Influence of sex and circadian cycle., PMID:39763388
RHO-Associated Coiled-Coil-Containing Protein Kinase Inhibitors Significantly Modulate the Epithelial-Mesenchymal Transition Induced by TGF-β2 in the 2-D and 3-D Cultures of Human Corneal Stroma Fibroblasts., PMID:39767691
Angelica gigas Nakai (Korean Dang-gui) Root Alcoholic Extracts in Health Promotion and Disease Therapy - active Phytochemicals and In Vivo Molecular Targets., PMID:39779619
Lingo1 in the hippocampus contributes to cognitive dysfunction after anesthesia and surgery in aged mice., PMID:39781463
Rnd3 Ameliorates Diabetic Cardiac Microvascular Injury via Facilitating Trim40-Mediated Rock1 Ubiquitination., PMID:39792251
Human parietal epithelial cells as Trojan horses in albumin overload., PMID:39800742
S1PR3 in hippocampal neurons improves synaptic plasticity and decreases depressive behavior via downregulation of RhoA/ROCK1., PMID:39828081
Activation of S1PR2 on macrophages and the hepatocyte S1PR2/RhoA/ROCK1/MLC2 pathway in vanishing bile duct syndrome., PMID:39854311
Hepatocyte Rho-associated kinase signaling is required for mice to survive experimental porphyria-associated liver injury., PMID:39878679
Pioneering first-in-class HDAC-ROCK inhibitors as potential multitarget anticancer agents., PMID:39885716
Discovery of Dual ROCK1/2 Inhibitors from Nocardiopsis sp. under Metal Stress., PMID:39893657
ROCK1 promotes B cell differentiation and proteostasis under stress through the heme-regulated proteins, BACH2 and HRI., PMID:39903532
The Protein Kinase aPKC as Well as the Small GTPases RhoA and Cdc42 Regulates Neutrophil Chemotaxis Partly by Recruiting the ROCK Kinase to the Leading Edge., PMID:39906004
Y-27632 Suppresses the Growth and Migration of Oral Squamous Cell Carcinoma, but Upregulates Autophagy by Suppressing mTOR Effectors., PMID:39921531
Myofibrillogenesis Regulator-1 in Smooth Muscle Cells Modulates Inflammation Signaling Pathways via Regulating ROCK1 Ubiquitination and Degradation to Impact Aortic Dissection., PMID:39931165
Increased Matrix Stiffness Promotes Slow Muscle Fibre Regeneration After Skeletal Muscle Injury., PMID:39969079
Polygala crotalarioides attenuates erectile dysfunction through improving Rho/ROCK signaling pathway mediated thyroid and gonadal function in kidney Yang deficiency ED rat., PMID:40043341
Identifcation of the FGF family as therapeutic targets and prognostic biomarkers in the microenvironment of head and neck squamous cell carcinoma., PMID:40086631
Research and progress of microRNA-136 in metastatic tumors., PMID:40104500
Four Novel Rho-associated Coiled-coil Protein Kinase 1 Inhibitors Suppressing Cytoskeleton and Movement in Breast Cancer Cells., PMID:40107880
Tetrahydropalmatine improves mitochondrial function in vascular smooth muscle cells of atherosclerosis in vitro by inhibiting Ras homolog gene family A/Rho-associated protein kinase-1 signaling pathway., PMID:40109328
Effect of four traditional Chinese medicine monomers on mechanical barrier damage and inflammation response of IPEC-J2 cells caused by soybean 7S globulin., PMID:40125324
The Minute Virus of Canines (MVC) Activates the RhoA/ROCK1/MLC2 Signal Transduction Pathway Resulting in the Dissociation of Tight Junctions and Facilitating Occludin-Mediated Viral Infection., PMID:40142587
Gastrodin Mitigates Ketamine-Induced Inhibition of F-Actin Remodeling and Cell Migration by Regulating the Rho Signaling Pathway., PMID:40149625
ROCK2 Downregulation in Pediatric Medulloblastoma Increases Migration and Predicts the Involvement of SHH Non-canonical Signaling., PMID:40165809
Rock inhibitors in Alzheimer's disease., PMID:40182055
Cell-intrinsic insulin signaling defects in human iPS cell-derived hepatocytes in type 2 diabetes., PMID:40231468
Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmacology, molecular docking and molecular dynamics simulations., PMID:40248103
Diosgenin in Dioscorea spongiosa Suppresses Glycolysis-Driven Angiogenesis as a ROCK1 Inhibitor., PMID:40252032
HuangE Capsules Improve Bladder Function in BOO-induced Overactive Bladder Rats: Network Pharmacology and Experimental Validation., PMID:40296623
MAGI1 attenuates osteoarthritis by regulating osteoclast fusion in subchondral bone through the RhoA-ROCK1 signaling pathway., PMID:40322041
Design, Synthesis, and Evaluation of Novel ROCK Inhibitors for Glaucoma Treatment: Insights into In Vitro and In Vivo Efficacy and Safety., PMID:40340390
Caspase-mediated cleavage of a scaffold protein, MPRIP, yields a truncated form that is involved in repetitive bleb formation., PMID:40344468
Sexual dimorphism of lung immune-regulatory units imprint biased pulmonary fibrosis., PMID:40360692
Secretory Profile Analysis of Human Granulosa Cell Line Following Gonadotropin Stimulation., PMID:40362347
Thymosin Beta-4 Modulates Cardiac Remodeling by Regulating ROCK1 Expression in Adult Mammals., PMID:40362372
Extracellular matrix stiffness in endometrial cancer: driving progression and modulating treatment sensitivity via the ROCK1/YAP1 axis., PMID:40368918
Downregulation of OIP5-AS1 inhibits apoptosis in myocardial ischemia/reperfusion injury via modulating the MiR-145-5p/ROCK1 axis., PMID:40392837
The roles of ROCK2/CBS-H2S pathway in the cerebral ischemia/reperfusion injury., PMID:40394784
Inhibition of Rho-associated kinases ROCK1 and ROCK2 as a Therapeutic Strategy to Reactivate the Repressed FXN Gene in Friedreich Ataxia., PMID:40404357
Androgen receptor plays critical role in regulating cervical cancer cell migration., PMID:40409531
Integrating LC-MS and molecular docking technology to investigate the effect of Spatholobi caulis flavonoids in alleviating primary dysmenorrhea via regulating the RhoA/ROCK pathway., PMID:40414437
MicroRNA-129-5p-mediated translational repression of microglial ROCK1 leads to enhanced phagocytosis., PMID:40419128
Nonylphenol exposure induces myocardial fibrosis via the RhoA/ROCK1/MLC-signaling pathway., PMID:40446736
Synergistic effects of CC chemokine receptor 2 inhibitor and transforming growth factor-β type I receptor kinase inhibitor combination in metabolic dysfunction-associated steatohepatitis., PMID:40494442
S1PR2 Mediates Smooth Muscle Cell Proliferation and Endothelial Cell Permeability via Akt/mTOR and RhoA/ROCK1 in Atherosclerosis., PMID:40495705
Protein kinase ROCK1 activates mitochondrial fission linking to oxidative stress and muscle atrophy., PMID:40505862
For research use only. Not for human or drug use.
