Catalog No.
YHK35601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp436-Lys752
Predicted molecular weight
39.12 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q8WYQ5
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
DGCRK6, Microprocessor complex subunit DGCR8, DiGeorge syndrome critical region 8, DGCR8, C22orf12
Note
For research use only.
Thirty Years with ERH: An mRNA Splicing and Mitosis Factor Only or Rather a Novel Genome Integrity Protector?, PMID:37887293
The relationship between prognosis of patients with traumatic brain injury and microRNA biogenesis proteins., PMID:37889026
Silencing METTL14 alleviates liver injury in non-alcoholic fatty liver disease by regulating mitochondrial homeostasis., PMID:37902450
MicroRNA-200 Loaded Lipid Nanoparticles Promote Intestinal Epithelium Regeneration in Canonical MicroRNA-Deficient Mice., PMID:37939210
Pycard deficiency inhibits microRNA maturation and prevents neointima formation by promoting chaperone-mediated autophagic degradation of AGO2/argonaute 2 in adipose tissue., PMID:37963060
Dgcr8 functions in the secondary heart field for outflow tract and right ventricle development in mammals., PMID:38110169
N6-methyladenosine-induced miR-182-5p promotes multiple myeloma tumorigenesis by regulating CAMK2N1., PMID:38180718
Prevalence, Molecular Landscape, and Clinical Impact of DICER1 and DGCR8 Mutated Follicular-Patterned Thyroid Nodules., PMID:38252873
Exposure to the extremely low-frequency electromagnetic field induces changes in the epigenetic regulation of gene expression in the endometrium., PMID:38262222
N4-acetylcytidine modifies primary microRNAs for processing in cancer cells., PMID:38308713
METTL14 affects UVB-induced human dermal fibroblasts photoaging via miR-100-3p biogenesis in an m6A-dependent manner., PMID:38380598
Small nucleolar RNA host gene 18 controls vascular smooth muscle cell contractile phenotype and neointimal hyperplasia., PMID:38498586
Role of miRNAs in Brain Development., PMID:38571343
Unraveling the Significance of DGCR8 and miRNAs in Thyroid Carcinoma., PMID:38607000
METTL14-mediated N6-methyladenosine modification induces the ferroptosis of hypoxia/reoxygenation-induced cardiomyocytes., PMID:38664788
The reduction of the m6A methyltransferase METTL3 in granulosa cells is related to the follicular cysts in pigs., PMID:38685566
Regulation of Microprocessor assembly and localization via Pasha's WW domain in C. elegans., PMID:38712061
Structural basis of pri-let-7 recognition by human pseudouridine synthase TruB1., PMID:38776834
METTL3 deficiency leads to ovarian insufficiency due to IL-1β overexpression in theca cells., PMID:38825211
Next-generation sequencing profiling of miRNAs in individuals with 22q11.2 deletion syndrome revealed altered expression of miR-185-5p., PMID:38872198
m5C methylated lncRncr3-MeCP2 interaction restricts miR124a-initiated neurogenesis., PMID:38879605
A transient transcriptional activation governs unpolarized-to-polarized morphogenesis during embryo implantation., PMID:38955180
miR-29a-3p orchestrates key signaling pathways for enhanced migration of human mesenchymal stem cells., PMID:39020373
[Advance of research on 22q11.2 deletion syndrome]., PMID:39097286
LncRNA KCNQ1OT1 promotes NLRP3 inflammasome activation in Parkinson's disease by regulating pri-miR-186/mature miR-186/NLRP3 axis., PMID:39122224
Proteomic changes of the bovine blood plasma in response to heat stress in a tropically adapted cattle breed., PMID:39149588
ARGONAUTE2 Localizes to Sites of Sporocysts in the Schistosome-Infected Snail, Biomphalaria glabrata., PMID:39202383
Epididymal acquired sperm microRNAs modify post-fertilization embryonic gene expression., PMID:39226174
Molecular mechanism of ALKBH5-mediated m6A demethylation regulating lipopolysaccharide-induced epithelial-mesenchymal transition in sepsis-induced acute kidney injury., PMID:39287046
A transcription-independent role for HIF-1α in modulating microprocessor assembly., PMID:39319577
Mitochondrial genome-derived circRNAs: Orphan epigenetic regulators in molecular biology., PMID:39321951
The structural landscape of Microprocessor-mediated processing of pri-let-7 miRNAs., PMID:39368465
FTO/m6A mediates miR-138-5p maturation and regulates gefitinib resistance of lung adenocarcinoma cells by miR-138-5p/LCN2 axis., PMID:39394098
AGO2 protein: a key enzyme in the miRNA pathway as a novel biomarker in adrenocortical carcinoma., PMID:39404265
ALKBH5 promotes T-cell acute lymphoblastic leukemia growth via m6A-guided epigenetic inhibition of miR-20a-5p., PMID:39442644
MicroRNA and Rare Human Diseases., PMID:39457367
Effects of METTL3-METTL14 on primary microRNA processing by Drosha-DGCR8., PMID:39464105
A functional connection between the Microprocessor and a variant NEXT complex., PMID:39515294
Elucidating the pathobiology of Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS) with its expanded RNA structure formation and proteinopathy., PMID:39543176
MicroRNA regulator gene mutations in thyroid follicular nodular disease and thyroid cancer: does it all come down to timing?, PMID:39601261
Mechanistic Insights of hsa-mir-301a Regulation by Tobacco Smoke in Lung Squamous Cell Carcinoma: Evidence From Bioinformatics Analysis., PMID:39619736
The biogenesis and regulation of animal microRNAs., PMID:39702526
METTL3 promotes renal ischemia-reperfusion injury by modulating miR-374b-5p/SRSF7 axis., PMID:39887511
METTL14-mediated m6A methylation of pri-miR-5099 to facilitate cardiomyocyte pyroptosis in myocardial infarction., PMID:39939804
Germline Pathogenic DROSHA Variants Are Linked to Pineoblastoma and Wilms Tumor Predisposition., PMID:39992227
Dysregulation of MicroRNA Biogenesis Machinery in Nervous System Diseases., PMID:40082738
DGCR8 haploinsufficiency leads to primate-specific RNA dysregulation and pluripotency defects., PMID:40138719
Dynamics and role of covalently-closed circular RNAs in Alzheimer's disease: A review of experimental and bioinformatics studies., PMID:40239316
Assessing Microprocessor Complex Mutations with a Microsensor System., PMID:40328469
Characteristics of the MicroRNA-Processing Enzymes in Melanocytic Skin Lesions: Dicer and DGCR8 Are Potential Biomarkers for Primary Cutaneous Melanomas., PMID:40344283
For research use only. Not for human or drug use.
