Catalog No.
YHH86401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Phe164-Tyr469
Predicted molecular weight
36.58 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q53EL6
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PDCD4, Neoplastic transformation inhibitor protein, Nuclear antigen H731-like, Protein 197/15a, H731, Programmed cell death protein 4
Note
For research use only.
STAT1 mediated downregulation of the tumor suppressor gene PDCD4, is driven by the atypical cadherin FAT1, in glioblastoma., PMID:38640981
Human tumor suppressor PDCD4 directly interacts with ribosomes to repress translation., PMID:38641729
18β-Glycyrrhetinic acid protects against deoxynivalenol-induced liver injury via modulating ferritinophagy and mitochondrial quality control., PMID:38657511
Low-Density Lipoproteins Increase Proliferation, Invasion, and Chemoresistance via an Exosome Autocrine Mechanism in MDA-MB-231 Chemoresistant Cells., PMID:38672098
Programmed cell death factor 4-mediated hippocampal synaptic plasticity is involved in early life stress and susceptibility to depression., PMID:38723677
Microglial Pdcd4 deficiency mitigates neuroinflammation-associated depression via facilitating Daxx mediated PPARγ/IL-10 signaling., PMID:38822367
Comprehensive analysis of the functions, prognostic and diagnostic values of RNA binding proteins in head and neck squamous cell carcinoma., PMID:38844022
RNA-Binding Protein Lin28B Promotes Chronic Myeloid Leukemia Blast Crisis by Transcriptionally Upregulating miR-181d., PMID:38847604
Specific and efficient knockdown of intracellular miRNA using partially neutralized phosphate-methylated DNA oligonucleic acid-loaded mesoporous silica nanoparticles., PMID:38872610
PDCD4 as a marker of mTOR pathway activation and therapeutic target in mycobacterial infections., PMID:38912807
Mesenchymal Stem Cell-Loaded Hydrogel Improves Surgical Treatment for Chronic Cerebral Ischemia., PMID:38977638
CRISPR screens in 3D tumourspheres identified miR-4787-3p as a transcriptional start site miRNA essential for breast tumour-initiating cell growth., PMID:39003349
Acupuncture Therapy Modulating "Du" Channel Attenuates Ischemic Stroke-induced Disorders by Modulating REST-mediated miR-21/PDCD4 Signaling Transduction., PMID:39031207
SMAD1 Regulates the Hippocampal Neuronal Death and Ferroptosis via Affecting the Transcription of PDCD4 in Cerebral Ischemia., PMID:39052186
Lnc NBAT1 Inhibits the Proliferation and Migration of Liver Cancer Cells Through the miR-21/PDCD4/AP-1 Signaling Axis., PMID:39093348
Role of MicroRNA-21 in Regulating Intracellular Pathways Associated With Phagocytosis in Human Macrophages: An In Vitro Study., PMID:39100039
PDCD4 triggers α-synuclein accumulation and motor deficits via co-suppressing TFE3 and TFEB translation in a model of Parkinson's disease., PMID:39107320
Human tumor suppressor protein Pdcd4 binds at the mRNA entry channel in the 40S small ribosomal subunit., PMID:39117603
CHO cell engineering via targeted integration of circular miR-21 decoy using CRISPR/RMCE hybrid system., PMID:39120640
Long noncoding RNA EPCART regulates translation through PI3K/AKT/mTOR pathway and PDCD4 in prostate cancer., PMID:39147845
PDCD4 interacting with PIK3CB and CTSZ promotes the apoptosis of multiple myeloma cells., PMID:39190024
MicroRNA-21 (miR-21) in breast cancer: From apoptosis dysregulation to therapeutic opportunities., PMID:39226804
PDCD4 promotes inflammation/fibrosis by activating the PPAR‑γ/NF‑κB pathway in mouse atrial myocytes., PMID:39301631
PDCD4 deficiency in hepatocytes exacerbates nonalcoholic steatohepatitis through enhanced MHC class II transactivator expression., PMID:39342987
Knockdown of IGF2BP3 Down-Regulates PDCD4 Levels to Attenuate Hypoxic-Ischemic Brain Damage., PMID:39344311
Oxycodone alleviates LPS-induced neuroinflammation by regulating the CREB/miR-181c/PDCD4 axis., PMID:39358233
Secretome from estrogen-responding human placenta-derived mesenchymal stem cells rescues ovarian function and circadian rhythm in mice with cyclophosphamide-induced primary ovarian insufficiency., PMID:39390588
The Impact of Pdcd4, a Translation Inhibitor, on Drug Resistance., PMID:39459035
Ergotamine Targets KIF5A to Facilitate Anoikis in Lung Adenocarcinoma., PMID:39517115
Cardiomyocyte-derived exosomes promote cardiomyocyte proliferation and neonatal heart regeneration., PMID:39560071
The significance of exosomal non-coding RNAs (ncRNAs) in the metastasis of colorectal cancer and development of therapy resistance., PMID:39643147
Loc646329 sponges miR-21 to reduce RAS/MAP kinase signaling pathway in oral squamous cell carcinoma (OSCC)., PMID:39673637
Anti-miR21-conjugated DNA nanohydrogel for enhanced cancer therapy., PMID:39731836
The crosstalk between SND1 and PDCD4 is associated with chemoresistance of non-small cell lung carcinoma cells., PMID:39885142
Discovery of a sushi domain-containing protein 2-positive phenotype in circulating tumor cells of metastatic breast cancer patients., PMID:39890941
IL-4-primed human umbilical cord mesenchymal stem cells-derived extracellular vesicles facilitate recovery in spinal cord injury via the miR-21-5p/PDCD4-mediated shifting of macrophage M1/M2 polarization., PMID:39909387
3D mesenchymal stem cell exosome-functionalized hydrogels for corneal wound healing., PMID:39955036
The Therapeutic Potential of MicroRNA-21 in the Treatment of Spinal Cord Injury., PMID:39996791
MicroRNA-21 Promotes the Viability, Proliferation and Milk Fat Synthesis of Ovine Mammary Epithelial Cells by Targeting PDCD4., PMID:40003924
Exploring miR-21 Knock-Out Using CRISPR/Cas as a Treatment for Lung Cancer., PMID:40004462
The kinase PLK1 promotes Hedgehog signaling-dependent resistance to the antiandrogen enzalutamide in metastatic prostate cancer., PMID:40100956
PDCD4 inhibition alleviates neuropathic pain by regulating spinal autophagy and neuroinflammation., PMID:40156089
Comprehensive Proteomics and Machine Learning Analysis to Distinguish Follicular Adenoma and Follicular Thyroid Carcinoma from Indeterminate Thyroid Nodules., PMID:40205804
MeCP2 Lactylation Protects against Ischemic Brain Injury by Transcriptionally Regulating Neuronal Apoptosis., PMID:40271828
Lapatinib-Resistant HER2+ Breast Cancer Cells Are Associated with Dysregulation of MAPK and p70S6K/PDCD4 Pathways and Calcium Management, Influence of Cryptotanshinone., PMID:40332401
Quantitative Proteomic Study Reveals Amygdalin Alleviates Liver Fibrosis Through Inhibiting mTOR/PDCD4/JNK Pathway in Hepatic Stellate Cells., PMID:40356680
TSPAN15 enhances EMT-mediated metastasis of HCC by promoting autophagy through BTRC-mediated PDCD4 degradation., PMID:40398082
Kudiezi injection attenuates apoptosis and neuroinflammation for ameliorating angiogenesis via miR-21/PDCD4/NF-κB axis in MCAO/reperfusion rats., PMID:40449697
Hsa-miR-21-5p is induced by interleukin-6 and affects multiple pathogenic factors associated with fibroblast-like synoviocytes in rheumatoid arthritis., PMID:40461641
Pan-cancer Analysis Predicts PDCD4 as a Potential Diagnostic, Prognostic and Immune Infiltration-related Biomarker., PMID:40471645
For research use only. Not for human or drug use.
