Anti-CDK1 Polyclonal Antibody

Catalog No.

PHC20201

Species reactivity

Human, Mouse, Rat

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human CDK1 (Met1-Met297).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

CDC28A,CDKN1,P34CDC2,p34 protein kinase,CDK1,Cell division protein kinase 1,Cell division control protein 2 homolog,CDC2,Cyclin-dependent kinase 1

Purification

Purified by antigen affinity column.

Accession

P06493

Applications

ELISA, IF, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Selective but not pan-CDK inhibition abrogates 5-FU-driven tissue factor upregulation in colon cancer., PMID:38719932

The dysfunction of CD8+ T cells triggered by endometriotic stromal cells promotes the immune survival of endometriosis., PMID:38544333

Differential anti-viral response to respiratory syncytial virus A in preterm and term infants., PMID:38447274

AZD1775 and anti-PD-1 antibody synergistically sensitize hepatoma to radiotherapy., PMID:38167245

PARP Inhibitor Sensitizes BRCA-mutant Pancreatic Cancer to Oxaliplatin by Suppressing the CDK1/BRCA1 Axis., PMID:38030179

ASPP2 Is Phosphorylated by CDK1 during Mitosis and Required for Pancreatic Cancer Cell Proliferation., PMID:38001686

Mammalian cells internalize bacteriophages and use them as a resource to enhance cellular growth and survival., PMID:37883333

Genomic and immune landscape Of metastatic pheochromocytoma and paraganglioma., PMID:36854674

Coxsackievirus A6 Infection Causes Neurogenic Pathogenesis in a Neonatal Murine Model., PMID:36851724

HUSH-mediated HIV silencing is independent of TASOR phosphorylation on threonine 819., PMID:36309692

Triacylglycerol lipase Tgl4 is a stable protein and its dephosphorylation is regulated in a cell cycle-dependent manner in Saccharomyces cerevisiae., PMID:35981421

Anlotinib suppresses proliferation, migration, and immune escape of gastric cancer cells by activating the cGAS-STING/IFN-β pathway., PMID:35471977

Conserved Mitotic Phosphorylation of a Proteasome Subunit Regulates Cell Proliferation., PMID:34831298

Activation of PKM2 metabolically controls fulminant liver injury via restoration of pyruvate and reactivation of CDK1., PMID:34425230

Use of Mitotic Protein Kinase Inhibitors and Phospho-Specific Antibodies to Monitor Protein Phosphorylation During the Cell Cycle., PMID:34085225

Knockdown of SASS6 reduces growth of MDA‑MB‑231 triple‑negative breast cancer cells through arrest of the cell cycle at the G2/M phase., PMID:33907854

SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins required for faithful chromosome segregation in human cells., PMID:33587225

Cdk1 phosphorylation negatively regulates the activity of Net1 towards RhoA during mitosis., PMID:33465404

G1 Cell Cycle Arrest and Extrinsic Apoptotic Mechanisms Underlying the Anti-Leukemic Activity of CDK7 Inhibitor BS-181., PMID:33352782

Dracocephalum heterophyllum (DH) Exhibits Potent Anti-Proliferative Effects on Autoreactive CD4+ T Cells and Ameliorates the Development of Experimental Autoimmune Uveitis., PMID:33117376

Phosphorylation of Msx1 promotes cell proliferation through the Fgf9/18-MAPK signaling pathway during embryonic limb development., PMID:33080014

Proteomic Analysis of Protein Ubiquitination Events in Human Primary and Metastatic Colon Adenocarcinoma Tissues., PMID:33014840

Wolbachia increase germ cell mitosis to enhance the fecundity of Laodelphax striatellus., PMID:32966874

ULK1-ATG13 and their mitotic phospho-regulation by CDK1 connect autophagy to cell cycle., PMID:32516310

CDK1 dependent phosphorylation of hTERT contributes to cancer progression., PMID:32214089

Theileria annulata surface protein (TaSP) is a target of cyclin-dependent kinase 1 phosphorylation in Theileria annulata-infected cells., PMID:32174040

A novel BCMA PBD-ADC with ATM/ATR/WEE1 inhibitors or bortezomib induce synergistic lethality in multiple myeloma., PMID:32060401

Lung IFNAR1hi TNFR2+ cDC2 promotes lung regulatory T cells induction and maintains lung mucosal tolerance at steady state., PMID:31959883

The therapeutic effectiveness of 177Lu-lilotomab in B-cell non-Hodgkin lymphoma involves modulation of G2/M cell cycle arrest., PMID:31836849

Cell-Cycle-Dependent Phosphorylation of PRPS1 Fuels Nucleotide Synthesis and Promotes Tumorigenesis., PMID:31253668

Involvement of Myt1 kinase in the G2 phase of the first cell cycle in Xenopus laevis., PMID:31128913

Marek's Disease Virus Regulates the Ubiquitylome of Chicken CD4+ T Cells to Promote Tumorigenesis., PMID:31035338

Synergistic efficacy of RLIP inhibition and 2'-hydroxyflavanone against DMBA-induced mammary carcinogenesis in SENCAR mice., PMID:31006917

Mitochondrial Function of CKS2 Oncoprotein Links Oxidative Phosphorylation with Cell Division in Chemoradioresistant Cervical Cancer., PMID:30856376

CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation., PMID:30765437

Combined Aurora Kinase A (AURKA) and WEE1 Inhibition Demonstrates Synergistic Antitumor Effect in Squamous Cell Carcinoma of the Head and Neck., PMID:30755439

In vitro neutralization of autocrine IL‑10 affects Op18/stathmin signaling in non‑small cell lung cancer cells., PMID:30320402

CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes., PMID:30154440

Transcriptional targeting of oncogene addiction in medullary thyroid cancer., PMID:30135308

Multipronged activity of combinatorial miR-143 and miR-506 inhibits Lung Cancer cell cycle progression and angiogenesis in vitro., PMID:30002440

Cdk1 phosphorylation of the dynein adapter Nde1 controls cargo binding from G2 to anaphase., PMID:29930206

Schaftoside Interacts With NlCDK1 Protein: A Mechanism of Rice Resistance to Brown Planthopper, Nilaparvata lugens., PMID:29896209

Regulation of keratin 5/14 intermediate filaments by CDK1, Aurora-B, and Rho-kinase., PMID:29518391

Characterization and validation of potential therapeutic targets based on the molecular signature of patient-derived xenografts in gastric cancer., PMID:29433585

Targeting PLK1 overcomes T-DM1 resistance via CDK1-dependent phosphorylation and inactivation of Bcl-2/xL in HER2-positive breast cancer., PMID:29391599

Identifying the ubiquitination targets of E6AP by orthogonal ubiquitin transfer., PMID:29263404

DNMT1 is associated with cell cycle and DNA replication gene sets in diffuse large B-cell lymphoma., PMID:29137822

Defective Cyclin B1 Induction in Trastuzumab-emtansine (T-DM1) Acquired Resistance in HER2-positive Breast Cancer., PMID:28821558

Prospective Review of Mesenchymal Stem Cells Differentiation into Osteoblasts., PMID:28276640

Gene expression profiling of anti-CTLA4-treated metastatic melanoma in patients with treatment-induced autoimmunity., PMID:27918555

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