Catalog No.
YHK80201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg450-Ser620
Predicted molecular weight
21.74 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UHC9
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NPC1L1, Niemann-Pick C1-like protein 1, NPC1-like intracellular cholesterol transporter 1
Note
For research use only.
Associations of lipids and lipid-modifying drug target genes with atrial fibrillation risk based on genomic data., PMID:38851763
Association of lipid-lowering drugs with risk of sarcopenia: a drug target mendelian randomization study and meta-analysis., PMID:38961447
Repurposing lipid-lowering drugs on asthma and lung function: evidence from a genetic association analysis., PMID:38961500
Association of lipid-lowering drugs with gut microbiota: A Mendelian randomization study., PMID:38971663
Exploring the causal effect between lipid-modifying drugs and idiopathic pulmonary fibrosis: a drug-target Mendelian randomization study., PMID:39090671
Platycodon D reduces obesity and non-alcoholic fatty liver disease induced by a high-fat diet through inhibiting intestinal fat absorption., PMID:39108759
Suppressive Effect of Coffee Leaves on Lipid Digestion and Absorption In Vitro., PMID:39123636
Comparative Evaluation of Micellization and Cellular Uptake of β-Carotene Affected by Flavonoids., PMID:39174497
Comparative Efficacy of Colchicine and Intensive Low-density Lipoprotein Cholesterol Lowering in Patients with Atherosclerotic Diseases receiving Statins: A Network Meta-analysis of Randomized Controlled Trials., PMID:39207624
Novel insights into the association between genetically proxied inhibition of proprotein convertase subtilisin/kexin type 9 and risk of sarcopenia., PMID:39254080
In silico comparative analysis of cestode and human NPC1 provides insights for ezetimibe repurposing to visceral cestodiases treatment., PMID:39261546
Association of lipids and lipid-lowering drugs with peripheral arterial disease: A Mendelian randomization study., PMID:39304430
Association between lipid-lowering agents with intervertebral disc degeneration, sciatica and low back pain: a drug-targeted mendelian randomized study and cross-sectional observation., PMID:39358768
Genetic association of lipids and lipid lowering drug target genes with sarcoidosis., PMID:39420052
A data mining approach to identify key radioresponsive genes in mouse model of radiation-induced intestinal injury., PMID:39431989
Evaluation of the role of hepatic Gstm4 in diet-induced obesity and dyslipidemia., PMID:39481188
How active cholesterol coordinates cell cholesterol homeostasis: Test of a hypothesis., PMID:39491591
Associations of blood lipids and LDL cholesterol lowering drug-targets with colorectal cancer risk: a Mendelian randomisation study., PMID:39580580
Niemann-Pick C1-like 1 as a Prognostic Marker in Renal Cell Carcinoma: A Retrospective Cohort Study., PMID:39598242
Lipid-lowering therapies for aortic stenosis: a drug-target Mendelian randomization study., PMID:39611306
Adapting Caenorhabditis elegans to evaluating functional foods and ingredients for cholesterol absorption., PMID:39663215
Genetic correlation between genes targeted by lipid-lowering drugs and venous thromboembolism: A drug-target Mendelian randomization study., PMID:39705479
Causal effects of circulating lipids and lipid-lowering drugs on the risk of atopic dermatitis: a mendelian randomization study., PMID:39718588
Lipids, lipid-lowering drugs and the risk of herpes zoster: a Mendelian randomization study., PMID:39755897
Integrated singlecell and bulk RNA-seq analysis identifies a prognostic signature related to inflammation in colorectal cancer., PMID:39757274
Cholesterol-Lowering Activity of Lactiplantibacillus pentosus KS6I1 in High-Cholesterol Diet-Induced Hypercholesterolemic Mice., PMID:39809508
Dual targeting PPARα and NPC1L1 metabolic vulnerabilities blocks tumorigenesis., PMID:39862918
Genetic association analysis of lipid-lowering drug target genes in chronic kidney disease., PMID:39877840
Associations of Lipid-Lowering Drugs With Blood Pressure and Fasting Glucose: A Mendelian Randomization Study., PMID:39902581
Associations between lipid-lowering drugs and urate and gout outcomes: a Mendelian randomization study., PMID:39926389
Microbiota-derived 3-Methyl-L-histidine mediates the proatherogenic effect of high chicken protein diet., PMID:39949981
Distinct pathways for the absorption and metabolism of β-carotene and zeaxanthin in the mouse intestine., PMID:39971162
Cholesin mRNA Expression in Human Intestinal, Liver, and Adipose Tissues., PMID:40004948
Phytosterol-Enriched Dietary Supplements for Lowering Plasma LDL-Cholesterol: Yes or No?, PMID:40004982
Glucose depletion reduces cholesterol intracellular accumulation in ABCB1-dependent mechanism., PMID:40036650
Expression of the Niemann-Pick C1-like 1 Protein in Gastric Cancer., PMID:40037881
Ezetimibe alters micelle structure and reduces Niemann-Pick C1-like 1-mediated absorption of vitamins E and K1 in CaCo-2 cells., PMID:40054527
Potential function of hepatic Niemann-Pick C1-like 1: cholesterol homeostasis regulation of the canalicular lipid bilayer membrane., PMID:40060220
Causal relationship between drug target genes of LDL-cholesterol and coronary artery disease: drug target Mendelian randomization study., PMID:40082904
Cloning, phylogenetic analysis, tissue expression profiling, and functional roles of NPC1L1 in chickens, quails, and ducks., PMID:40106905
Development of a prognostic risk model for colorectal cancer and association of the prognostic model with cancer stem cell and immune cell infiltration., PMID:40115909
Triglyceride-lowering effect of rice protein due to the regulation of fatty acid uptake and transport of triglyceride in rats fed normal/oil-enriched diets., PMID:40135185
Intestinal IL-25 prevents high-fat diet-induced obesity by modulating the cholesterol transporter NPC1L1 expression in the intestinal epithelial cells., PMID:40140439
Identification of a Novel NPC1L1 Inhibitor from Danshen and Its Role in Nonalcoholic Fatty Liver Disease., PMID:40141435
Causal Association Between Cholesterol-Lowering Drugs and Diabetic Microvascular Complications: A Drug-Target Mendelian Randomization Study., PMID:40225015
Effects of opium on cholesterol metabolism in rats fed normal and high-fat/high-cholesterol diet., PMID:40230514
Association between lipid-lowering drug targets and the risk of cystic kidney disease: a drug-target Mendelian randomization analysis., PMID:40289090
Causal Associations Between Lipids, NPC1L1, and Liver Cancer Risk: Insights From Mendelian Randomization and Bioinformatics., PMID:40312834
Discovery of novel diagnostic biomarkers of hepatocellular carcinoma associated with immune infiltration., PMID:40440122
Transporters in vitamin uptake and cellular metabolism: impacts on health and disease., PMID:40444179
For research use only. Not for human or drug use.
