Catalog No.
DHJ48303
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG1-kappa
Clonality
Monoclonal
Target
PLAB, Placental bone morphogenetic protein, MIC1, NRG-1, PTGFB, NSAID-regulated gene 1 protein, GDF15, NAG-1, MIC-1, Prostate differentiation factor, NSAID-activated gene 1 protein, Growth/differentiation factor 15, Macrophage inhibitory cytokine 1, Placental TGF-beta, GDF-15, PDF
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q99988
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
AV-380, AV 380, AV380
Clone ID
AV 380
Interplay between sarcopenia, GDF-15, and the efficacy of nivolumab plus ipilimumab in patients with mismatch repair deficient metastatic colorectal cancer: final survival analysis of the phase II GERCOR NIPICOL study., PMID:40389373
Randomized Phase II Study of Nab-Paclitaxel and Gemcitabine With or Without Tocilizumab as First-Line Treatment in Advanced Pancreatic Cancer: Survival and Cachexia., PMID:40354592
First-in-Human Study to Evaluate the Safety and Efficacy of Anti-GDF15 Antibody AZD8853 in Patients with Advanced/Metastatic Solid Tumors., PMID:40354065
1000-plex antibody array proteomic screen uncovers PGRPS, Haptoglobin, Serpin A4 and Fibrinogen as potential stool biomarkers of pediatric inflammatory bowel disease., PMID:40252987
GDF-15 blockade: A multi-directional approach to potentiate cancer immunotherapy and alleviate cancer cachexia., PMID:40159463
Circulating GDF15 May Estimate Vasculitis Activity and Predict Poor Outcomes During the Disease Course of ANCA-Associated Vasculitis., PMID:40142684
Establishment of GDF15 time-resolved fluorescence immunoassay and its clinical application in colorectal cancer., PMID:40118237
Growth differentiation factor 15 aggravates sepsis-induced cognitive and memory impairments by promoting microglial inflammatory responses and phagocytosis., PMID:39985040
GDF15 Neutralization Ameliorates Muscle Atrophy and Exercise Intolerance in a Mouse Model of Mitochondrial Myopathy., PMID:39976232
Inhibiting monoclonal antibody GDF-15 improves cancer cachexia symptoms., PMID:39832072
Molecular and Functional Significance of Growth Differentiation Factor-15: A Review on Cardiovascular-Kidney-Metabolic Biomarker., PMID:39781722
Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours., PMID:39663448
Reversing resistance to cancer immune therapy with antibodies that target GDF-15 protein., PMID:39663439
A highly sensitive fluorescence biosensor based on polylysine functionalized quantum dots for serum GDF-15 detection., PMID:39613492
Immunogenicity assessment strategy for a chemically modified therapeutic protein in clinical development., PMID:39588370
GDF15 research from bench to bedside., PMID:39454578
GB18-06, a nanobody targeting GDF15, effectively alleviates weight loss and restores physical function in cachexia models., PMID:39400041
Ponsegromab for the Treatment of Cancer Cachexia., PMID:39282907
Biomarker-enhanced cardiovascular risk prediction in patients with cancer: a prospective cohort study., PMID:39223063
Secreted GDF15 maintains transcriptional responses during DNA damage-mediated senescence in human beta cells., PMID:39196800
Neutralizing antibody against GDF15 for treatment of cancer-associated cachexia., PMID:39172988
Polyneuropathy in systemic sclerosis: exploring the causes and biomarkers., PMID:39156689
The impact of the expression level of growth differentiation factor 15 in tumor tissue on the response to immunotherapy in non-small cell lung cancer., PMID:39103762
Macrophages as a Source and Target of GDF-15., PMID:39000420
Cancer Cachexia in STK11/LKB1 -mutated NSCLC is Dependent on Tumor-secreted GDF15., PMID:38948776
Bidirectional Two-Sample Mendelian Randomization Study of Immunoglobulin G N-Glycosylation and Senescence-Associated Secretory Phenotype., PMID:38928043
New quasi-Co/Cu-MOF nanozyme coupled with entropy-driven DNA amplification cascades for highly sensitive electrochemical aptamer growth differentiation factor 15 assay., PMID:38879214
Updates in Cancer Cachexia: Clinical Management and Pharmacologic Interventions., PMID:38730648
Phase 2 study of the efficacy and safety of ponsegromab in patients with cancer cachexia: PROACC-1 study design., PMID:38500292
Antibody Profiling: Kinetics with Native Biomarkers for Diagnostic Assay and Drug Developments., PMID:38131790
A Phase Ib First-In-Patient Study Assessing the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Ponsegromab in Participants with Cancer and Cachexia., PMID:37982848
Biomarkers in the Pathogenesis, Diagnosis, and Treatment of Systemic Sclerosis., PMID:37868834
Tumor-derived GDF-15 blocks LFA-1 dependent T cell recruitment and suppresses responses to anti-PD-1 treatment., PMID:37474523
Immune sensing of food allergens promotes avoidance behaviour., PMID:37437602
GDF15 Mediates the Effect of Skeletal Muscle Contraction on Glucose-Stimulated Insulin Secretion., PMID:37224335
GDNF family receptor alpha-like antagonist antibody alleviates chemotherapy-induced cachexia in melanoma-bearing mice., PMID:37017344
Biomarker Changes Associated With Both Dulaglutide and Cardiovascular Events in the REWIND Randomized Controlled Trial: A Nested Case-Control Post Hoc Analysis., PMID:36897834
A Nrf2-OSGIN1&2-HSP70 axis mediates cigarette smoke-induced endothelial detachment: implications for plaque erosion., PMID:36804807
An electrochemical immunosensor based on polyaniline microtubules and zinc gallinate for detection of human growth differentiation factor-15., PMID:36790563
The landscape of cancer cachexia in advanced non-small cell lung cancer: a narrative review., PMID:36762058
Immune sensing of food allergens promotes aversive behaviour., PMID:36712030
Inflammatory markers and pulmonary function in adolescents and young adults 6 months after mild COVID-19., PMID:36685555
GDF15 neutralization restores muscle function and physical performance in a mouse model of cancer cachexia., PMID:36640326
Identification and validation of circulating biomarkers for detection of liver cancer with antibody array., PMID:36620875
Soluble tumor endothelial marker 1 in heart failure with reduced ejection fraction: A pilot study., PMID:36588577
GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cell carcinoma., PMID:36525138
The GDF15-GFRAL axis mediates chemotherapy-induced fatigue in mice., PMID:36427806
Increased Density of Growth Differentiation Factor-15+ Immunoreactive M1/M2 Macrophages in Prostate Cancer of Different Gleason Scores Compared with Benign Prostate Hyperplasia., PMID:36230513
Transforming Growth Factor-Beta Signaling in Cancer-Induced Cachexia: From Molecular Pathways to the Clinics., PMID:36078078
GDF-15 and sST-2 act as biomarkers of disease severity but not independent predictors in idiopathic membranous nephropathy., PMID:36027852
For research use only. Not for human or drug use.
