Please ensure Javascript is enabled for purposes of website accessibility
Home / Products / Research Biosimilar

Research Grade Anti-Human TIE1 (DX-2240)

Catalog #:   DHE13401 Specific References (50) DATASHEET
Host species: Human
Isotype: IgG
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHE13401

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG

Clonality

Monoclonal

Target

TIE, Tyrosine-protein kinase receptor Tie-1, TIE1

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P35590

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

DX-2240, DX 2240, DX2240

Clone ID

DX-2240

Data Image
References

Loss of MXRA8 Delays Mammary Tumor Development and Impairs Metastasis., PMID:37762032

In vitro inhibition of cancer angiogenesis and migration by a nanobody that targets the orphan receptor Tie1., PMID:35604495

Aptamer-Assisted Protein Orientation on Silver Magnetic Nanoparticles: Application to Sensitive Leukocyte Cell-Derived Chemotaxin 2 Surface Plasmon Resonance Sensors., PMID:35045701

Patho-Mechanisms for Hemorrhage/Sepsis-Induced Indirect Acute Respiratory Distress Syndrome: A Role for Lung TIE1 and Its Regulation by Neutrophils., PMID:34907117

[Advances of Angiopoietin-Tie axis in vascular and lymphatic system-related diseases]., PMID:34472284

Dual inhibition of PFKFB3 and VEGF normalizes tumor vasculature, reduces lactate production, and improves chemotherapy in glioblastoma: insights from protein expression profiling and MRI., PMID:32641990

A new Tie1 targeted antibody blocks tumor cell extravasation and metastasis., PMID:32406209

Preclinical validation of a novel metastasis-inhibiting Tie1 function-blocking antibody., PMID:32302470

Bevacizumab treatment of meningeal melanoma metastases., PMID:31915016

High baseline Tie1 level predicts poor survival in metastatic breast cancer., PMID:31340773

Anatomy of the coronary artery and cardiac vein in the quail ventricle: patterns are distinct from those in mouse and human hearts., PMID:29948975

Stereological and immunogold studies on TIE1 and TIE2 localization in glomeruli indicate angiopoietin signaling in podocytes., PMID:28288344

Sustained inflammation after pericyte depletion induces irreversible blood-retina barrier breakdown., PMID:28194443

The Osmopressor-Induced Angiopoietin-1 Secretion in Plasma and Subsequent Activation of the Tie-2/Akt/eNOS Signaling Pathway in Red Blood Cell., PMID:28034894

Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation., PMID:27548529

CD146(+) cells are essential for kidney vasculature development., PMID:27165833

Tie2-dependent deletion of α6 integrin subunit in mice reduces tumor growth and angiogenesis., PMID:25176420

Tie1 deletion inhibits tumor growth and improves angiopoietin antagonist therapy., PMID:24430181

Embryogenesis of the first circulating endothelial cells., PMID:23737938

Comprehensive timeline of mesodermal development in the quail small intestine., PMID:22930586

Angiogenesis is crucial for liver regeneration after partial hepatectomy., PMID:22862899

Consistent MYC and FLT4 gene amplification in radiation-induced angiosarcoma but not in other radiation-associated atypical vascular lesions., PMID:20949568

Regulation of lymphatic-blood vessel separation by endothelial Rac1., PMID:19906871

Role of Ceacam1 in VEGF induced vasculogenesis of murine embryonic stem cell-derived embryoid bodies in 3D culture., PMID:19285068

Endothelial endothelin-1 over-expression using receptor tyrosine kinase tie-1 promoter leads to more severe vascular permeability and blood brain barrier breakdown after transient middle cerebral artery occlusion., PMID:19230825

Differential analyses of angiogenesis and expression of growth factors in micro- and macrovascular endothelial cells of type 2 diabetic rats., PMID:19135459

Cell-autonomous requirement for beta1 integrin in endothelial cell adhesion, migration and survival during angiogenesis in mice., PMID:18480158

Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival., PMID:17504972

Mapping of angiogenic markers for targeting of vectors to tumor vascular endothelial cells., PMID:17235351

Essential functions of Alk3 during AV cushion morphogenesis in mouse embryonic hearts., PMID:16959237

Vascularization in tissue remodeling after rat hepatic necrosis induced by dimethylnitrosamine., PMID:16575513

Localization of the angiopoietin receptors Tie-1 and Tie-2 on the primary cilia in the female reproductive organs., PMID:15893943

Stretch induces upregulation of key tyrosine kinase receptors in microvascular endothelial cells., PMID:15548727

Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular development., PMID:15223333

Derivation of endothelial cells from CD34- umbilical cord blood., PMID:15153615

Establishment and characterization of an angiosarcoma-derived cell line, AS-M., PMID:14741847

The new Tie-1 monoclonal antibodies detect angiogenesis in metastatic malignancies., PMID:14506179

Targeting endothelial growth with monoclonal antibodies against Tie-1 kinase in mouse models., PMID:14506178

Overexpression of the receptor tyrosine kinase Tie-1 intracellular domain in breast cancer., PMID:12853700

Clinical significance of AXL kinase family in gastric cancer., PMID:12168903

NERF2, a member of the Ets family of transcription factors, is increased in response to hypoxia and angiopoietin-1: a potential mechanism for Tie2 regulation during hypoxia., PMID:11967990

Stable expression of angiopoietin-1 and other markers by cultured pericytes: phenotypic similarities to a subpopulation of cells in maturing vessels during later stages of angiogenesis in vivo., PMID:11950897

Embryonic stem cell-derived embryoid bodies development in collagen gels recapitulates sprouting angiogenesis., PMID:11742037

Spatiotemporal expression of angiogenesis growth factor receptors during the revascularization of regenerating rat liver., PMID:11732003

Expression of tyrosine kinase receptors Tie-1 and Tie-2 in giant cell tumor of the tendon sheath: a possible role in synovial proliferation., PMID:11261813

Expression of endothelial cell angiogenesis receptors in human cerebrovascular malformations., PMID:11220380

Elf-1 is a transcriptional regulator of the Tie2 gene during vascular development., PMID:11157678

Endothelial growth factor receptors in human fetal heart., PMID:10441093

Potential roles of metalloprotease mediated ectodomain cleavage in signaling by the endothelial receptor tyrosine kinase Tie-1., PMID:10418829

Endothelial cell culture from human cerebral cavernous malformations., PMID:9804658

Datasheet
$ 328
Product specifications
100 μg 328 1 mg 1314

Contact Information

Order: order@antibodysystem.com

Mail: support@antibodysystem.com

Distributor list

For research use only. Not for human or drug use.

Need help with your order?

Find out more about placing an order here

Research Grade Anti-Human TIE1 (DX-2240) [DHE13401]
Terms of sale Website terms of use Cookie policy Privacy
Copyright © 2025 AntibodySystem SAS. All Rights Reserved.            All Products are for Research Use Only