Please ensure Javascript is enabled for purposes of website accessibility
Home / Products / Research Biosimilar

Research Grade Olokizumab

Catalog #:   DHC15804 Specific References (72) DATASHEET
Host species: Humanized
Isotype: IgG4-kappa
Applications: Research Grade Biosimilar
Expression system: Mammalian Cells
Overview

Catalog No.

DHC15804

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Humanized

Isotype

IgG4-kappa

Clonality

Monoclonal

Target

Hybridoma growth factor, BSF-2, IFN-beta-2, CDF, IL6, Interleukin-6, IL-6, B-cell stimulatory factor 2, Interferon beta-2, IFNB2, CTL differentiation factor

Concentration

1 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

P05231

Applications

Research Grade Biosimilar

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

CDP 6038, CAS: 1007223-17-7

Clone ID

Olokizumab

Data Image
  • SDS-PAGE
    SDS PAGE for Olokizumab
  • Bioactivity
    Detects IL6 in indirect ELISAs.
  • SEC-HPLC
    The purity of this product is >95% as determined by SEC-HPLC.
References

[Anti-IL-6 : new therapeutic trends], PMID: 28703549

[Experience of olokizumab use in COVID-19 patients], PMID: 33720587

[IL-6 blockade], PMID: 27311186

Analysis of miRNA Expression in Patients with Rheumatoid Arthritis during Olokizumab Treatment, PMID: 33142700

Antibodies to watch in 2021, PMID: 33459118

Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors, PMID: 32847008

Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling, PMID: 24670876

Efficacy and safety of olokizumab in Asian patients with moderate-to-severe rheumatoid arthritis, previously exposed to anti-TNF therapy: Results from a randomized phase II trial, PMID: 26358841

Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study, PMID: 24641941

Efficacy of pharmacological treatment in rheumatoid arthritis: a systematic literature research informing the 2019 update of the EULAR recommendations for management of rheumatoid arthritis, PMID: 32033937

IL-6 inhibitors for treatment of rheumatoid arthritis: past, present, and future, PMID: 25648633

IL-6 targeting compared to TNF targeting in rheumatoid arthritis: studies of olokizumab, sarilumab and sirukumab, PMID: 24833786

Interleukin-6 blocking agents for treating COVID-19: a living systematic review, PMID: 33734435

Interleukin-6 inhibition in the management of non-infectious uveitis and beyond, PMID: 31523783

Long-term safety and efficacy of olokizumab in patients with rheumatoid arthritis and inadequate response to tumor necrosis factor inhibitor therapy in phase II studies, PMID: 34101570

Model-Based Optimal Design and Execution of the First-Inpatient Trial of the Anti-IL-6, Olokizumab, PMID: 24941311

Olokizumab, a monoclonal antibody against interleukin 6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by methotrexate: efficacy and safety results of a randomised controlled phase III study, PMID: 34344706

Probing binding mechanism of interleukin-6 and olokizumab: in silico design of potential lead antibodies for autoimmune and inflammatory diseases, PMID: 26982101

Profile of sarilumab and its potential in the treatment of rheumatoid arthritis, PMID: 28579757

Rheumatoid arthritis: new monoclonal antibodies, PMID: 29771256

Safety and pharmacokinetics of olokizumab, an anti-IL-6 monoclonal antibody, administered to healthy male volunteers: A randomized phase I study, PMID: 27129012

Targeting interleukin-6 for noninfectious uveitis, PMID: 26392750

Correction: Olokizumab plus methotrexate: safety and efficacy over 106 weeks of treatment., PMID:39919910

EFFICACY AND SAFETY OF OLOKIZUMAB IN THE MANAGEMENT OF RHEUMATOID ARTHRITIS- A SYSTEMATIC REVIEW AND META-ANALYSIS., PMID:39585284

Olokizumab effect on chronic pain in rheumatoid arthritis: Results of the PROLOGUE observational study., PMID:39441547

Efficacy and safety of current therapies for difficult-to-treat rheumatoid arthritis: a systematic review and network meta-analysis., PMID:39198829

Identification of critical genes and metabolic pathways in rheumatoid arthritis and osteoporosis toward drug repurposing., PMID:39079412

Inflammation-mediated drug interactions of olokizumab and cytochrome P450 activities in patients with rheumatoid arthritis., PMID:38984761

Results of a 12-Week Open-Label, Non-Interventional Study of the Efficacy and Safety of Olokizumab Therapy in Patients with Rheumatoid Arthritis after Switching from Anti-B-Cell Therapy during the SARS-CoV-2 Pandemic., PMID:38955912

Olokizumab plus methotrexate: safety and efficacy over 106 weeks of treatment., PMID:38955475

Efficacy of Olokizumab against Comorbid Depressive Disorder in Patients with Rheumatoid Arthritis: Preliminary Results of the Study., PMID:38861142

Text Mining and Drug Discovery Analysis: A Comprehensive Approach to Investigate Diabetes-Induced Osteoporosis., PMID:38250601

Targeting IL-6 or IL-6 Receptor in Rheumatoid Arthritis: What Have We Learned?, PMID:37989892

Comparison of the efficacy and safety of olokizumab at different dosages in patients with active rheumatoid arthritis: a network meta-analysis of randomized controlled trials., PMID:37266677

Interleukin-6 blocking agents for treating COVID-19: a living systematic review., PMID:37260086

[Clinical cases of complicated diverticulitis against the background of severe course COVID-19. Case report]., PMID:37167171

NEUROPROTECTIVE AND ANTIOXIDANT POTENTIAL OF MONTELUKAST-ACETYLCYSTEINE COMBINATION THERAPY FOR BRAIN PROTECTION IN PATIENTS WITH COVID-19 INDUCED PNEUMONIA., PMID:37042600

Targeting Olokizumab-Interleukin 6 interaction interface to discover novel IL-6 inhibitors., PMID:36995131

Identification of potential molecular mechanisms and candidate drugs for radiotherapy- and chemotherapy-induced mucositis., PMID:36939936

The efficacy and safety of olokizumab for rheumatoid arthritis: a systematic review, pairwise, and network meta-analysis., PMID:36792848

Comparison of the efficacy and safety of tocilizumab, sarilumab, and olokizumab in patients with active rheumatoid arthritis: a network meta-analysis of randomized controlled trials., PMID:36607422

Olokizumab's Effectiveness and Safety in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials., PMID:36535857

Efficacy of synthetic and biological DMARDs: a systematic literature review informing the 2022 update of the EULAR recommendations for the management of rheumatoid arthritis., PMID:36368906

Olokizumab, a monoclonal antibody against interleukin-6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by tumour necrosis factor inhibitor therapy: efficacy and safety results of a randomised controlled phase III study., PMID:36109142

Olokizumab versus Placebo or Adalimumab in Rheumatoid Arthritis., PMID:36001712

Drug discovery in spinal cord injury-induced osteoporosis: a text mining-based study., PMID:35957736

Genetic and Clinical Factors Associated with Olokizumab Treatment in Russian Patients with Rheumatoid Arthritis., PMID:35455757

A Novel Humanized Anti-Interleukin-6 Antibody HZ0408b With Anti-Rheumatoid Arthritis Therapeutic Potential., PMID:35126375

Impact of olokizumab on platelets, leukocytes and erythrocytes during mild COVID-19., PMID:34565057

Olokizumab, a monoclonal antibody against interleukin 6, in combination with methotrexate in patients with rheumatoid arthritis inadequately controlled by methotrexate: efficacy and safety results of a randomised controlled phase III study., PMID:34344706

What do we know about IL-6 in COVID-19 so far?, PMID:37287491

Long-term safety and efficacy of olokizumab in patients with rheumatoid arthritis and inadequate response to tumor necrosis factor inhibitor therapy in phase II studies., PMID:34101570

Interleukin-6 blocking agents for treating COVID-19: a living systematic review., PMID:33734435

[Experience of olokizumab use in COVID-19 patients]., PMID:33720587

Antibodies to watch in 2021., PMID:33459118

Analysis of miRNA Expression in Patients with Rheumatoid Arthritis during Olokizumab Treatment., PMID:33142700

Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors., PMID:32847008

Efficacy of pharmacological treatment in rheumatoid arthritis: a systematic literature research informing the 2019 update of the EULAR recommendations for management of rheumatoid arthritis., PMID:32033937

Interleukin-6 inhibition in the management of non-infectious uveitis and beyond., PMID:31523783

Rheumatoid arthritis: new monoclonal antibodies., PMID:29771256

[Anti-IL-6 : new therapeutic trends]., PMID:28703549

Profile of sarilumab and its potential in the treatment of rheumatoid arthritis., PMID:28579757

[IL-6 blockade]., PMID:27311186

Probing binding mechanism of interleukin-6 and olokizumab: in silico design of potential lead antibodies for autoimmune and inflammatory diseases., PMID:26982101

Targeting interleukin-6 for noninfectious uveitis., PMID:26392750

Efficacy and safety of olokizumab in Asian patients with moderate-to-severe rheumatoid arthritis, previously exposed to anti-TNF therapy: Results from a randomized phase II trial., PMID:26358841

IL-6 inhibitors for treatment of rheumatoid arthritis: past, present, and future., PMID:25648633

Safety and pharmacokinetics of olokizumab, an anti-IL-6 monoclonal antibody, administered to healthy male volunteers: A randomized phase I study., PMID:27129012

Model-Based Optimal Design and Execution of the First-Inpatient Trial of the Anti-IL-6, Olokizumab., PMID:24941311

IL-6 targeting compared to TNF targeting in rheumatoid arthritis: studies of olokizumab, sarilumab and sirukumab., PMID:24833786

Discovery and characterization of olokizumab: a humanized antibody targeting interleukin-6 and neutralizing gp130-signaling., PMID:24670876

Efficacy and safety of olokizumab in patients with rheumatoid arthritis with an inadequate response to TNF inhibitor therapy: outcomes of a randomised Phase IIb study., PMID:24641941

Datasheet

Document Download

Research Grade Olokizumab.pdf

 

$ 372
Product specifications
100 μg 372 1 mg 1486

Contact Information

Order: order@antibodysystem.com

Mail: support@antibodysystem.com

Distributor list

For research use only. Not for human or drug use.

Need help with your order?

Find out more about placing an order here

Research Grade Olokizumab [DHC15804]
Terms of sale Website terms of use Cookie policy Privacy
Copyright © 2025 AntibodySystem SAS. All Rights Reserved.            All Products are for Research Use Only