Catalog No.
DHD62605
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Clonality
Monoclonal
Target
IL-4RA, IL-4-binding protein, IL-4 receptor subunit alpha, Soluble IL-4R-alpha, IL4-BP, IL4R, IL-4R subunit alpha, IL-4R-alpha, CD124, Interleukin-4 receptor subunit alpha, IL4RA, Soluble IL-4 receptor subunit alpha, sIL4Ralpha/prot
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P24394
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
AMG-317, AMG 317, AMG317
Clone ID
AMG 317
Mapping knowledge structure and research of the biologic treatment of asthma: A bibliometric study., PMID:36845128
Human lung tissue provides highly relevant data about efficacy of new anti-asthmatic drugs., PMID:30500834
Biomarkers in the clinical development of asthma therapies., PMID:26764286
Comparison of cell-based and non-cell-based assay platforms for the detection of clinically relevant anti-drug neutralizing antibodies for immunogenicity assessment of therapeutic proteins., PMID:25795420
Noninvasive biomarkers that predict treatment benefit from biologic therapies in asthma., PMID:24313774
The utility of modeling and simulation approaches to evaluate immunogenicity effect on the therapeutic protein pharmacokinetics., PMID:23139019
Stratification of antibody-positive subjects by antibody level reveals an impact of immunogenicity on pharmacokinetics., PMID:23054969
Population PK and IgE pharmacodynamic analysis of a fully human monoclonal antibody against IL4 receptor., PMID:21604075
Use of the Asthma Control Questionnaire to predict future risk of asthma exacerbation., PMID:21093024
Asthma & COPD--IQPC's Second Conference., PMID:20799138
A randomized, controlled, phase 2 study of AMG 317, an IL-4Ralpha antagonist, in patients with asthma., PMID:20056900
Gateways to clinical trials., PMID:19557204
Gateways to clinical trials., PMID:18773127
For research use only. Not for human or drug use.
