Catalog No.
DHJ58901
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Clonality
Monoclonal
Target
IL1R-rp2, IL1RL2, IL1RRP2, IL-1Rrp2, IL-36 receptor, Interleukin-1 receptor-related protein 2, Interleukin-1 receptor-like 2, IL-36R
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9HB29
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
REGN6490
Clone ID
REGN6490
IL1RAP Expression in Human Atherosclerosis: A Target of Novel Antibodies to Reduce Vascular Inflammation and Adhesion., PMID:40371594
Blocking IL1RAP on cancer-associated fibroblasts in pancreatic ductal adenocarcinoma suppresses IL-1-induced neutrophil recruitment., PMID:39694705
Efficacy and Safety of the Anti-IL1RAP Antibody Nadunolimab (CAN04) in Combination with Gemcitabine and Nab-Paclitaxel in Patients with Advanced/Metastatic Pancreatic Cancer., PMID:39385434
IL1RAP-specific T cell engager depletes acute myeloid leukemia stem cells., PMID:39143574
Interleukin-1 receptor accessory protein blockade limits the development of atherosclerosis and reduces plaque inflammation., PMID:38563353
Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor., PMID:35003094
First-in-human phase 1 dose-escalation study of CAN04, a first-in-class interleukin-1 receptor accessory protein (IL1RAP) antibody in patients with solid tumours., PMID:34903842
IL-36γ and IL-36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress-Induced Cell Death., PMID:34369094
Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma., PMID:34021002
Distinct Gene Expression Signatures Characterize Strong Clinical Responders Versus Nonresponders to Canakinumab in Children With Systemic Juvenile Idiopathic Arthritis., PMID:33452871
Structure-based Development of Human Interleukin-1β-Specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP., PMID:33359099
The Role of SNPs in IL1RL1 and IL1RAP Genes in Age-related Macular Degeneration Development and Treatment Efficacy., PMID:32871771
Preclinical characterization of the ADME properties of a surrogate anti-IL-36R monoclonal antibody antagonist in mouse serum and tissues., PMID:32310023
X-ray crystal structure localizes the mechanism of inhibition of an IL-36R antagonist monoclonal antibody to interaction with Ig1 and Ig2 extra cellular domains., PMID:32239732
Spesolimab: A Novel Treatment for Pustular Psoriasis., PMID:32208020
IL-1R3 blockade broadly attenuates the functions of six members of the IL-1 family, revealing their contribution to models of disease., PMID:31427775
[IL-1RAP as a candidate for CAR T-cells immunotherapy]., PMID:31274074
Retrospective analysis of model-based predictivity of human pharmacokinetics for anti-IL-36R monoclonal antibody MAB92 using a rat anti-mouse IL-36R monoclonal antibody and RNA expression data (FANTOM5)., PMID:31068073
CML Hematopoietic Stem Cells Expressing IL1RAP Can Be Targeted by Chimeric Antigen Receptor-Engineered T Cells., PMID:30514753
Inhibiting Interleukin 36 Receptor Signaling Reduces Fibrosis in Mice With Chronic Intestinal Inflammation., PMID:30452921
IL-36 receptor antagonistic antibodies inhibit inflammatory responses in preclinical models of psoriasiform dermatitis., PMID:30417427
IL-38 has an anti-inflammatory action in psoriasis and its expression correlates with disease severity and therapeutic response to anti-IL-17A treatment., PMID:30377293
Synthetic human monoclonal antibody targets hIL1 receptor accessory protein chain with therapeutic potential in triple-negative breast cancer., PMID:30257318
An analysis of IL-36 signature genes and individuals with IL1RL2 knockout mutations validates IL-36 as a psoriasis therapeutic target., PMID:29021166
Generation and functional characterization of anti-human and anti-mouse IL-36R antagonist monoclonal antibodies., PMID:28726542
Interleukin-36β provides protection against HSV-1 infection, but does not modulate initiation of adaptive immune responses., PMID:28724920
Altered expression of IL36γ and IL36 receptor (IL1RL2) in the colon of patients with Hirschsprung's disease., PMID:27853811
IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models., PMID:27621309
[Cloning of VH and VL Gene of Human anti-IL1RAP McAb and Construction of Recombinant Chimeric Receptor]., PMID:26524021
[Preparation and Assessment of IL1RAP Monoclonal Antibody]., PMID:26314426
Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia., PMID:26261316
[Construction of hybridoma cells with IL1RAP as a new marker for leukemia stem cells and detection of its monoclonal antibody]., PMID:24370017
Selective killing of candidate AML stem cells by antibody targeting of IL1RAP., PMID:23479569
Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein., PMID:20805474
Human hepatitis B viral e antigen interacts with cellular interleukin-1 receptor accessory protein and triggers interleukin-1 response., PMID:16973626
Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs., PMID:14734551
Model of interaction of the IL-1 receptor accessory protein IL-1RAcP with the IL-1beta/IL-1R(I) complex., PMID:11418113
IL-18 receptors, their role in ligand binding and function: anti-IL-1RAcPL antibody, a potent antagonist of IL-18., PMID:11046021
Interleukin-1 receptor accessory protein interacts with the type II interleukin-1 receptor., PMID:9662436
Antibodies to domains II and III of the IL-1 receptor accessory protein inhibit IL-1 beta activity but not binding: regulation of IL-1 responses is via type I receptor, not the accessory protein., PMID:9531272
Functional epitope mapping of human interleukin-1 beta by surface plasmon resonance., PMID:9262965
Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex., PMID:7775431
For research use only. Not for human or drug use.
