Catalog No.
PHC05201
Species reactivity
Human, Mouse, Rat
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human HMGCR (Glu441-Asn875).
Tested applications
ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000
Target
3-hydroxy-3-methylglutaryl-coenzyme A reductase,HMGCR,HMG-CoA reductase
Purification
Purified by antigen affinity column.
Accession
P04035
Applications
ELISA, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Statin-associated immune-mediated necrotizing myopathy in Hispanic Americans., PMID:40446701
From cranes to crutches: the disabling potential of necrotising myopathy., PMID:40441745
Anti-HMGCR myopathy: a first case report from North Africa and literature insights., PMID:40421031
In immune-mediated necrotising myopathy, anti-HMGCR antibodies inhibit HMGCR activity, leading to the sarcoplasmic accumulation of lipid droplets and myofibres necrosis., PMID:40410054
Anti-HMGCR antibodies can be accurately detected by indirect immunofluorescence on HEp-2000 substrate., PMID:40383694
Emerging atypical clinicopathological manifestations of immune-mediated necrotizing myopathy (IMNM)., PMID:40315785
Subacute Cardiomyopathy Due to Statin Treatment: Can It Be True?-Case Report and Literature Review., PMID:40283184
Dysphagia During Pharyngeal and Esophageal Phase of Seronegative Immune-Mediated Necrotizing Myopathy: A Case Report., PMID:40264623
Effectiveness of proprotein convertase subtilisin/kexin type 9 inhibitors in managing hypercholesterolemia post-statin-associated immune-mediated necrotizing myopathy: report of five cases and literature review., PMID:40249406
Pediatric Immune-Mediated Necrotizing Myopathy: A Single-Center Retrospective Cohort Study., PMID:40203548
Clinicopathological features of anti-HMGCR and anti-SRP myopathies that do not satisfy the EULAR/ACR criteria of inflammatory myopathies., PMID:40178989
Persistent exanthema mainly on the trunk with pathologically dermal interstitial mucin as anti-HMGCR myopathy-associated skin rash: Case series., PMID:40152349
Progressive Muscle Weakness: Identifying Necrotizing Autoimmune Myopathy as a Rare Culprit., PMID:40109791
Precise identification and tracking of HMGCR-reactive CD4+ T cells in the target tissue of patients with anti-HMGCR immune-mediated necrotising myopathy., PMID:39919903
Predictive value of myositis antibodies: role of semiquantitative classification and positivity for more than one autoantibody., PMID:39837620
Applicability of a serodiagnostic line blot for idiopathic inflammatory myopathy: the muscle biopsy is not all., PMID:39835155
Therapeutic plasmapheresis as an effective treatment for refractory anti-3-hydroxy-3-methylglutaryl coenzyme A reductase-positive immune-mediated necrotising myopathy., PMID:39828311
Effects of HMG CoA reductase (HMGCR) deficiency on skeletal muscle development., PMID:39823152
Lipids, lipid-lowering drugs and the risk of herpes zoster: a Mendelian randomization study., PMID:39755897
Effectiveness and Safety of IVIG for the Treatment of HMGCR Immune-Mediated Necrotizing Myopathy., PMID:39731314
Statin-Induced Necrotizing Autoimmune Myopathy: Diagnosis and Treatment Approach., PMID:39659392
Case report: Rapid clinical improvement of anti-HMGCR immune-mediated necrotizing myopathy treated with efgartigimod., PMID:39569185
Clinicopathological and imaging differences between pediatric and adult patients with anti-hydroxy-3-methyl-glutaryl-coenzyme A reductase necrotizing myopathy., PMID:39562394
Statin-Induced Necrotizing Autoimmune Myopathy: An Uncommon yet Challenging Complication of Statin Use., PMID:39529788
[Not Available]., PMID:39534931
Pediatric case of immune-mediated necrotizing myopathy with anti-HMGCR antibodies and dermatomyositis skin rash., PMID:39511553
Treatment of refractory immune-mediated necrotizing myopathy with efgartigimod., PMID:39502686
A Case of Statin-Induced Necrotizing Autoimmune Myopathy., PMID:39493067
Immune-Mediated Necrotizing Myopathy With Anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) Antibodies Following Viral Infection and Without Association With Statin Use: A Case Report., PMID:39463677
Involvement of erector spinae muscles in a case of systemic lupus erythematosus with anti-HMGCR antibody., PMID:39288327
Pathogenic mechanisms of disease in idiopathic inflammatory myopathies: autoantibodies as clues., PMID:39281689
The first reported familial case of statin-induced immune-mediated necrotizing myopathy associated with anti-hydroxy-3-methylglutaryl-CoA reductase autoantibodies and HLA DRB1*11:01., PMID:39279651
Association of anti-HMGCR antibodies of the IgM isotype with refractory immune-mediated necrotizing myopathy., PMID:39261921
Anti-HMGCR myopathy mimicking facioscapulohumeral muscular dystrophy., PMID:39247442
Clinical and persistent remission in anti-HMGCR immune-mediated necrotizing myopathy to a single cycle of rituximab - a case-based review., PMID:39243358
Absence of Pathogenic Mutations and Strong Association With HLA-DRB1*11:01 in Statin-Naïve Early-Onset Anti-HMGCR Necrotizing Myopathy., PMID:39106428
Anti-HMGCR myopathy: Diversity of clinical presentations in a national cohort in New Zealand., PMID:39079206
Benefits of Early Versus Late Initiation of Intravenous Immunoglobulin in the Treatment of Patients With Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Immune-Mediated Necrotizing Myopathy., PMID:39054727
Distinct phenotype and prognosis of immune-mediated necrotizing myopathy based on clinical-serological-pathological classification., PMID:39029922
Diffuse Large B-cell Lymphoma Complicated with Anti-3-hydroxy-3-methylglutaryl-Coenzyme A Reductase Immune-mediated Necrotizing Myopathy., PMID:38987186
Ophthalmoparesis as an unusual manifestation of anti-3‑hydroxy-3-methyl-glutaryl-coenzyme A reductase antibody-associated myopathies., PMID:38981343
Anti-HMGCR (Hydroxy-3-Methylglutaryl-CoA Reductase) Myopathy: A Rare Cause of Proximal Muscle Weakness., PMID:38919212
Upregulated miR-146b-3p predicted rheumatoid arthritis development and regulated TNF-α-induced excessive proliferation, motility, and inflammation in MH7A cells., PMID:38902605
Management of immune-mediated necrotizing myopathy., PMID:38801022
Anti-HMGCR myopathy: estimated five-fold higher incidence in Polynesian compared with European populations in Aotearoa/New Zealand., PMID:38796685
Association of lipid-lowering drug targets with risk of cutaneous melanoma: a mendelian randomization study., PMID:38760735
Six Years Follow-Up of an 11-Year-Old Girl with Anti-HMGCR Myopathy., PMID:38759023
[Immune-Mediated Necrotizing Myopathy]., PMID:38741508
Atypical skin conditions of the neck and back as a dermal manifestation of anti-HMGCR antibody-positive myopathy., PMID:38734636
Perioperative Management of Paraneoplastic Necrotizing Myopathy in Thyroidectomy: A Case Report., PMID:38694410
For research use only. Not for human or drug use.
