Catalog No.
DHD80301
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG
Clonality
Monoclonal
Target
PC cell-derived growth factor, Granulin G, Epithelin precursor, Epithelin-1, Granulin A, Acrogranin, Progranulin, Granulin F, Proepithelin, PGRN, Glycoprotein of 88 Kda, GRN, Granulin C, Granulin E, Granulin precursor, PEPI, PCDGF, Granulin D, Glycoprotein 88, Epithelin-2, GP88, Granulin B
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P28799
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
AG1
Clone ID
AG1
A progranulin variant causing childhood interstitial lung disease responsive to anti-TNF-α biologic therapy., PMID:40020677
Progranulin AAV gene therapy for frontotemporal dementia: translational studies and phase 1/2 trial interim results., PMID:38745011
PGRN is involved in macrophage M2 polarization regulation through TNFR2 in periodontitis., PMID:38689292
Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression., PMID:35013174
Progranulin correlated with rapid progressive interstitial lung disease in dermatomyositis with anti-melanoma differentiation-associated gene 5 antibody., PMID:34718893
Serum GP88 as a predictive biomarker for hepatocellular carcinoma in patients with viral hepatitis C after direct-acting antiviral agents., PMID:34284614
Anti-progranulin/GP88 antibody AG01 inhibits triple negative breast cancer cell proliferation and migration., PMID:33616772
Development of disease-modifying drugs for frontotemporal dementia spectrum disorders., PMID:32203398
Progranulin autoantibodies in systemic sclerosis and autoimmune connective tissue disorders: A preliminary study., PMID:31502765
Progranulin promotes melanoma progression by inhibiting natural killer cell recruitment to the tumor microenvironment., PMID:31491449
A Highly Sensitive Sandwich ELISA to Detect CSF Progranulin: A Potential Biomarker for CNS Disorders., PMID:30939191
Immunohistochemical Detection of Progranulin (PGRN/GP88/GEP) in Tumor Tissues as a Cancer Prognostic Biomarker., PMID:29956272
Measurement of Circulating Progranulin (PGRN/GP88/GEP) by Enzyme-Linked Immunosorbent Assay and Application in Human Diseases., PMID:29956271
Higher levels of progranulin in cerebrospinal fluid of patients with lymphoma and carcinoma with CNS metastasis., PMID:29340960
Disease and Region Specificity of Granulin Immunopositivities in Alzheimer Disease and Frontotemporal Lobar Degeneration., PMID:29044416
Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration., PMID:28877758
Intracellular Proteolysis of Progranulin Generates Stable, Lysosomal Granulins that Are Haploinsufficient in Patients with Frontotemporal Dementia Caused by GRN Mutations., PMID:28828399
Association between increased serum GP88 (progranulin) concentrations and prognosis in patients with malignant lymphomas., PMID:28823651
Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma., PMID:28601093
Increased cerebrospinal fluid progranulin correlates with interleukin-6 in the acute phase of neuromyelitis optica spectrum disorder., PMID:28100408
Potential of Theranostic Target Mining in the Development of Novel Diagnostic and Therapeutic Products in Oncology: Progranulin/GP88 as a Therapeutic and Diagnostic Target for Breast and Lung Cancers., PMID:30695312
Progranulin and granulin-like protein as novel VEGF-independent angiogenic factors derived from human mesothelioma cells., PMID:27345409
Asymmetric pathology in primary progressive aphasia with progranulin mutations and TDP inclusions., PMID:26791154
Progranulin deficiency induces overactivation of WNT5A expression via TNF-α/NF-κB pathway in peripheral cells from frontotemporal dementia-linked granulin mutation carriers., PMID:26624524
The molecular basis for development of proinflammatory autoantibodies to progranulin., PMID:26005049
[Preparation and characterization of monoclonal antibodies against F domain of human progranulin]., PMID:25854577
Antibody against granulin-epithelin precursor sensitizes hepatocellular carcinoma to chemotherapeutic agents., PMID:25253787
High-throughput epitope binning assays on label-free array-based biosensors can yield exquisite epitope discrimination that facilitates the selection of monoclonal antibodies with functional activity., PMID:24651868
Proinflammatory progranulin antibodies in inflammatory bowel diseases., PMID:24591016
Progranulin antibodies entertain a proinflammatory environment in a subgroup of patients with psoriatic arthritis., PMID:24321127
Determining the binding affinity of therapeutic monoclonal antibodies towards their native unpurified antigens in human serum., PMID:24223227
TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia., PMID:23742080
The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding., PMID:23706646
Expression level of the growth factor progranulin is related with development of systemic lupus erythematosus., PMID:23702100
Progranulin antibodies in autoimmune diseases., PMID:23149338
Serum progranulin levels are elevated in patients with systemic lupus erythematosus, reflecting disease activity., PMID:23140401
Label-free epitope binning assays of monoclonal antibodies enable the identification of antigen heterogeneity., PMID:22609372
Recent advances in the genetics of the ALS-FTLD complex., PMID:22477152
The clinical and pathological phenotype of C9ORF72 hexanucleotide repeat expansions., PMID:22300876
Progranulin stimulated by LPA promotes the migration of aggressive breast cancer cells., PMID:22176685
Clinicopathologic and prognostic implications of progranulin in breast carcinoma., PMID:22088468
Towards the next generation of anti-TNF drugs., PMID:22004846
Low plasma progranulin levels in children with autism., PMID:21892962
New horizons in natural TNF-α antagonist research., PMID:21802362
Domain-specific monoclonal antibodies produced against human PGRN., PMID:21707362
A quantitative study of the neuropathology of 32 sporadic and familial cases of frontotemporal lobar degeneration with TDP-43 proteinopathy (FTLD-TDP)., PMID:21696412
Phosphorylated TDP-43 in Alzheimer's disease and dementia with Lewy bodies., PMID:19139911
The role of ADAMTS-7 and ADAMTS-12 in the pathogenesis of arthritis., PMID:19098927
Progranulin (PGRN) expression in ALS: an immunohistochemical study., PMID:18848708
Expression of PC cell-derived growth factor and vascular endothelial growth factor in esophageal squamous cell carcinoma and their clinicopathologic significance., PMID:18706200
For research use only. Not for human or drug use.
