Research Grade Anti-Human CD357/TNFRSF18/GITR (TRX518)

Catalog No.

DHJ89807

Expression system

Mammalian Cells

Species reactivity

Human

Host species

Human

Isotype

IgG1-kappa

Clonality

Monoclonal

Applications

Research Grade Biosimilar

Target

Activation-inducible TNFR family receptor, GITR, TNFRSF18, CD357, Tumor necrosis factor receptor superfamily member 18, AITR, Glucocorticoid-induced TNFR-related protein

Concentration

3.5 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

Q9Y5U5

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Alternative Names

TRX518

Clone ID

TRX518

Note

For research use only. Not suitable for clinical or therapeutic use.

IBC's 21st Annual Antibody Engineering and 8th Annual Antibody Therapeutics International Conferences and 2010 Annual Meeting of the Antibody Society. December 5-9, 2010, San Diego, CA USA., PMID:21304271

Rational design of anti-GITR-based combination immunotherapy., PMID:31036879

Therapeutic antibody activation of the glucocorticoid-induced TNF receptor by a clustering mechanism., PMID:35213218

Phase IB Study of GITR Agonist Antibody TRX518 Singly and in Combination with Gemcitabine, Pembrolizumab, or Nivolumab in Patients with Advanced Solid Tumors., PMID:35499569

GITR Antibodies in Cancer: Not Ready for Prime Time., PMID:35834593

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Research Grade Anti-Human CD357/TNFRSF18/GITR (TRX518).pdf