Catalog No.
FHH30110
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a
Clonality
Monoclonal
Conjugation
Unconjugated
Target
AZ3B, HNFAG09, C3AR1, C3R1, C3a-R, C3a anaphylatoxin chemotactic receptor, C3AR
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q16581
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0776
Effects of C3aR activated mast cells in eosinophilic esophagitis., PMID:40502038
Mechanisms of Mt.b Ag85B-Fc fusion protein against allergic asthma in mice by intranasal immunization., PMID:39549815
C3aR-initiated signaling is a critical mechanism of podocyte injury in membranous nephropathy., PMID:38227377
Potential causal role of synovial complement system activation in the development of post-traumatic osteoarthritis after anterior cruciate ligament injury or meniscus tear., PMID:37207197
Cntnap4 partial deficiency exacerbates α-synuclein pathology through astrocyte-microglia C3-C3aR pathway., PMID:37087484
Immune Profiling Panel Gene Set Identifies Critically Ill Patients With Low Monocyte Human Leukocyte Antigen-DR Expression: Preliminary Results From the REAnimation Low Immune Status Marker (REALISM) Study., PMID:36917594
Cutting Edge: Neutrophil Complement Receptor Signaling Is Required for BAFF-Dependent Humoral Responses in Mice., PMID:36454023
The Role of Genetic Factors in the Development of Acute Respiratory Viral Infection COVID-19: Predicting Severe Course and Outcomes., PMID:35327350
Identification of diagnostic markers and immune cell infiltration characteristics in antineutrophil cytoplasmic antibody-associated vasculitis by weighted gene co-expression network analysis., PMID:35246248
Identification and Validation of CYBB, CD86, and C3AR1 as the Key Genes Related to Macrophage Infiltration of Gastric Cancer., PMID:34950700
Identification of Key Genes and Underlying Mechanisms in Acute Kawasaki Disease Based on Bioinformatics Analysis., PMID:34290221
Dynamic regulation of B cell complement signaling is integral to germinal center responses., PMID:34031614
Autoantibodies against C5aR1, C3aR1, CXCR3, and CXCR4 are decreased in primary Sjogren's syndrome., PMID:33446393
Altered glycosylation of IgG4 promotes lectin complement pathway activation in anti-PLA2R1-associated membranous nephropathy., PMID:33351779
Protection of hUC-MSCs against neuronal complement C3a receptor-mediated NLRP3 activation in CUMS-induced mice., PMID:33161108
The Complement Receptors C3aR and C5aR Are a New Class of Immune Checkpoint Receptor in Cancer Immunotherapy., PMID:31379815
Inhibition of the alternative complement pathway accelerates repair processes in the murine model of choroidal neovascularization., PMID:30763805
Expression of complement C3, C5, C3aR and C5aR1 genes in resting and activated CD4+ T cells., PMID:30612786
Omalizumab normalizes the gene expression signature of lesional skin in patients with chronic spontaneous urticaria: A randomized, double-blind, placebo-controlled study., PMID:29974963
Complement Activation via a C3a Receptor Pathway Alters CD4+ T Lymphocytes and Mediates Lung Cancer Progression., PMID:29118090
Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a., PMID:28839129
Cardiac fibroblast transcriptome analyses support a role for interferogenic, profibrotic, and inflammatory genes in anti-SSA/Ro-associated congenital heart block., PMID:28626076
Complement component C3aR constitutes a novel regulator for chick eye morphogenesis., PMID:28576690
New concepts on the therapeutic control of complement anaphylatoxin receptors., PMID:28576324
Complement Activation by Giardia duodenalis Parasites through the Lectin Pathway Contributes to Mast Cell Responses and Parasite Control., PMID:26831470
Complement Split Products C3a/C5a and Receptors: Are They Regulated by Circulating Angiotensin II Type 1 Receptor Autoantibody in Severe Preeclampsia?, PMID:26485247
Complement C3a binding to its receptor as a negative modulator of Th2 response in liver injury in trichloroethylene-sensitized mice., PMID:24974766
Complement 5a receptor mediates angiotensin II-induced cardiac inflammation and remodeling., PMID:24743429
The complement C3a receptor is critical in defense against Chlamydia psittaci in mouse lung infection and required for antibody and optimal T cell response., PMID:24273177
Inhibition of complement activation alleviates acute lung injury induced by highly pathogenic avian influenza H5N1 virus infection., PMID:23526211
Anaphylatoxin receptors and complement regulatory proteins in human articular and non-articular chondrocytes: interrelation with cytokines., PMID:23053049
Autoantibody-mediated complement C3a receptor activation contributes to the pathogenesis of preeclampsia., PMID:22868393
Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice., PMID:22728083
Complement C3a-induced IL-17 plays a critical role in an IgE-mediated late-phase asthmatic response and airway hyperresponsiveness via neutrophilic inflammation in mice., PMID:22539791
Role of C3a receptors, C5a receptors, and complement protein C6 deficiency in collagen antibody-induced arthritis in mice., PMID:22205026
Complement and the alternative pathway play an important role in LPS/D-GalN-induced fulminant hepatic failure., PMID:22069473
Complement inhibition alleviates paraquat-induced acute lung injury., PMID:21421909
Decay accelerating factor (CD55) protects neuronal cells from chemical hypoxia-induced injury., PMID:20380727
C3a receptor deficiency accelerates the onset of renal injury in the MRL/lpr mouse., PMID:19167760
Complement gene expression in human cardiac allograft biopsies as a correlate of histologic grade of injury., PMID:19005416
Mast cell activation is characterized by upregulation of a functional anaphylatoxin C5a receptor., PMID:18559098
Overexpression of the anaphylatoxin receptors, complement anaphylatoxin 3a receptor and complement anaphylatoxin 5a receptor, in the nasal mucosa of patients with mild and severe persistent allergic rhinitis., PMID:18538384
Use of monoclonal antibodies to assess expression of anaphylatoxin receptors in rat and murine models of lung inflammation., PMID:17544263
High levels of complement C3a receptor in the glomeruli in lupus nephritis., PMID:17472841
Ablation of the complement C3a anaphylatoxin receptor causes enhanced killing of Pseudomonas aeruginosa in a mouse model of pneumonia., PMID:16461429
Characterization of a C3a receptor in rainbow trout and Xenopus: the first identification of C3a receptors in nonmammalian species., PMID:16081814
Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis., PMID:16034139
Pharmacological targeting of anaphylatoxin receptors during the effector phase of allergic asthma suppresses airway hyperresponsiveness and airway inflammation., PMID:15634899
Regulation by complement C3a and C5a anaphylatoxins of cytokine production in human umbilical vein endothelial cells., PMID:12773483
Complement receptors in HIV infection., PMID:12462391
For research use only. Not for human or drug use.
