Anti-C1QA Polyclonal Antibody

Catalog No.

PHC00201

Species reactivity

Human

Host species

Rabbit

Isotype

IgG

Clonality

Polyclonal

Immunogen

E. coli - derived recombinant Human C1QA (Ala28-Ala245).

Tested applications

ELISA: 1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000

Target

C1QA,Complement C1q subcomponent subunit A

Purification

Purified by antigen affinity column.

Accession

P02745

Applications

ELISA, IHC, WB

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Effects of C3aR activated mast cells in eosinophilic esophagitis., PMID:40502038

A novel complement C1q A chain from marbled flounder, Pseudopleuronectes yokohamae: genome characterization, expression and potential role in antibacterial immunity., PMID:40349809

Malaria exposure remodels the plasma proteome of Ghanaian children., PMID:39901099

Monogenic lupus with neuroregression in an infant due to rare compound heterozygous variants in C1QA gene: Case-based review., PMID:39096524

Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease., PMID:38589621

In a novel autoimmune and high-pressure glaucoma model a complex immune response is induced., PMID:38515755

Myeloid cell iron uptake pathways and paramagnetic rim formation in multiple sclerosis., PMID:37715818

Potential biomarkers for psoriasis topical treatment by in-depth serum proteomics., PMID:37621164

Identification of plasma proteins associated with oesophageal cancer chemotherapeutic treatment outcomes using SWATH-MS., PMID:35842220

[Relationship of C1QA level and therapeutic effect and prognosis of DLBCL patients treated with R-CHOP]., PMID:34915642

Single-cell multi-omics analysis of the immune response in COVID-19., PMID:33879890

Bovine neonate is deficient in innate immunity at birth., PMID:33640760

Functional recombinant human complement C1q with different affinity tags., PMID:33621564

Genomic Mapping Identifies Mutations in RYR2 and AHNAK as Associated with Favorable Outcome in Basal-Like Breast Tumors Expressing PD1/PD-L1., PMID:32796628

Neuronal impairment following chronic Toxoplasma gondii infection is aggravated by intestinal nematode challenge in an IFN-γ-dependent manner., PMID:31352901

Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia., PMID:31118110

Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration., PMID:30126455

Systemic lupus erythematosus with C1q deficiency: treatment with fresh frozen plasma., PMID:29113537

C1q-Dependent Dendritic Cell Cross-Presentation of In Vivo-Formed Antigen-Antibody Complexes., PMID:28432146

The production and secretion of complement component C1q by human mast cells., PMID:27648858

Plasma-derived Extracellular Vesicles Contain Predictive Biomarkers and Potential Therapeutic Targets for Myocardial Ischemic (MI) Injury., PMID:27234505

The complement system of elasmobranches revealed by liver transcriptome analysis of a hammerhead shark, Sphyrna zygaena., PMID:26987526

Soluble IgM links apoptosis to complement activation in early alcoholic liver disease in mice., PMID:26922040

C1q Modulates the Response to TLR7 Stimulation by Pristane-Primed Macrophages: Implications for Pristane-Induced Lupus., PMID:26773156

IgG Suppresses Antibody Responses in Mice Lacking C1q, C3, Complement Receptors 1 and 2, or IgG Fc-Receptors., PMID:26619292

Changes in markers associated with dendritic cells driving the differentiation of either TH2 cells or regulatory T cells correlate with clinical benefit during allergen immunotherapy., PMID:26522402

Crystallization and preliminary crystallographic studies of the complement 1qA globular domain from zebrafish, Dare-C1qAgD., PMID:25005087

Homozygous A polymorphism of the complement C1qA276 correlates with prolonged overall survival in patients with diffuse large B cell lymphoma treated with R-CHOP., PMID:22897949

Identification of patients with indolent B cell lymphoma sensitive to rituximab monotherapy., PMID:22083514

Essential role of factor B of the alternative complement pathway in complement activation and opsonophagocytosis during acute pneumococcal otitis media in mice., PMID:21502587

Binding to complement factors and activation of the alternative pathway by Acanthamoeba., PMID:20627448

Characterization of C1q in teleosts: insight into the molecular and functional evolution of C1q family and classical pathway., PMID:20615881

Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA., PMID:19656971

Immunoglobulin M is required for protection against atherosclerosis in low-density lipoprotein receptor-deficient mice., PMID:19620499

A polymorphism in the complement component C1qA correlates with prolonged response following rituximab therapy of follicular lymphoma., PMID:18927313

Identification of chromosome intervals from 129 and C57BL/6 mouse strains linked to the development of systemic lupus erythematosus., PMID:16943797

Monocytosis and accelerated activation of lymphocytes in C1q-deficient autoimmune-prone mice., PMID:15312138

Natural antibodies and complement are endogenous adjuvants for vaccine-induced CD8+ T-cell responses., PMID:14502281

Complement activation determines the therapeutic activity of rituximab in vivo., PMID:12874252

C1q regulatory region polymorphism down-regulating murine c1q protein levels with linkage to lupus nephritis., PMID:12133956

Z39Ig is co-expressed with activated macrophage genes., PMID:11997108

C1q deficiency and autoimmunity: the effects of genetic background on disease expression., PMID:11859149

Intact B cell tolerance in the absence of the first component of the classical complement pathway., PMID:11449362

Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2., PMID:11067882

Cutting edge: C1q protects against the development of glomerulonephritis independently of C3 activation., PMID:10229798

C1q binding to liposomes is surface charge dependent and is inhibited by peptides consisting of residues 14-26 of the human C1qA chain in a sequence independent manner., PMID:10209207

T cell-dependent immune response in C1q-deficient mice: defective interferon gamma production by antigen-specific T cells., PMID:9607920

Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies., PMID:9590289

Immunoglobulin-like domain of HIV-1 envelope glycoprotein gp120 encodes putative internal image of some common human proteins., PMID:7576036

Modulation of type II collagen-induced arthritis in DBA/1 mice by intravenous application of a peptide from the C1q-A chain., PMID:1398737

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