Catalog No.
YHC20901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn30-Val217
Predicted molecular weight
24.25 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P06730
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Eukaryotic translation initiation factor 4E, eIF-4E, eIF4E, eIF-4F 25 kDa subunit, mRNA cap-binding protein, EIF4E, EIF4EL1, EIF4F
Note
For research use only.
Integrating fragment-based screening with targeted protein degradation and genetic rescue to explore eIF4E function., PMID:40016190
Molecular Markers of Occult Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma (HNSCC) Patients., PMID:40018925
Discovery of Potent and Selective MNK Kinase Inhibitors for the Treatment of Leukemia., PMID:40033556
TSC2 loss in neural progenitor cells suppresses mRNA translation of neurodevelopmental genes., PMID:40037376
ANGEL2 modulates wildtype TP53 translation and doxorubicin chemosensitivity in colon cancer., PMID:40052999
Integrated network pharmacology, proteomics, molecular docking, and experiments in vivo and in vitro to explore the efficacy and potential mechanism of bufalin against hepatocellular carcinoma angiogenesis., PMID:40057142
Eukaryotic initiation factors eIF4F and eIF4B promote translation termination upon closed-loop formation., PMID:40066881
Establishment and characterization study of ovine mammary organoids., PMID:40108665
Chemical Probes for Studying the Eukaryotic Translation Initiation Factor 4E (eIF4E)-Regulated Translatome in Cancer., PMID:40109752
Two eIF4E paralogs occupy separate germ granule messenger ribonucleoproteins that mediate mRNA repression and translational activation., PMID:40119742
Hippocampal Inhibitory Interneuron-Specific DREADDs Treatment Alters mTORC1-4E-BP Signaling and Impairs Memory Formation., PMID:40123570
20-hydroxyecdysone via upregulating 4EBP expression and inhibiting its phosphorylation represses cell proliferation to permit insect larval molting., PMID:40134338
EIF4E1B interacts with HSPA1A and PPP2CA and is involved in mouse oocyte maturation and early embryonic development., PMID:40139147
Plasticity of the mammalian integrated stress response., PMID:40140574
Emerging Roles of m7G-Cap Hypermethylation and Nuclear Cap-Binding Proteins in Bypassing Suppression of eIF4E-Dependent Translation., PMID:40143300
Insulin-like Growth Factor-I Reduces Collagen Production by Hepatic Stellate Cells Through Stimulation of Collagen Degradation System via mTOR-Dependent Signaling Pathway., PMID:40149542
The Proteins Diversity of the eIF4E Family in the eIF4F Complex., PMID:40164153
The causal relationship between circulating inflammatory proteins and heart failure: A two-sample Mendelian randomization study., PMID:40184136
Exosomal 4EBP1 promotes head and neck cancer progression via regulating mitochondrial fission., PMID:40188596
Preparation, and enzymatic activity analysis of an engineered capping enzyme., PMID:40188656
Proximity interactome of alphavirus replicase component nsP3 includes proviral host factors eIF4G and AHNAK., PMID:40193402
TFEB and TFE3 regulate STING1-dependent immune responses by controlling type I interferon signaling., PMID:40195022
Estrogen-induced FXR1 promotes endocrine resistance and bone metastasis in breast cancer via BCL2 and GPX4., PMID:40196843
Editorial Expression of Concern: Heat shock protein 27 confers resistance to androgen ablation and chemotherapy in prostate cancer cells through eIF4E., PMID:40210762
Downregulation of PD-L1 expression by Wnt pathway inhibition to enhance PD-1 blockade efficacy in hepatocellular carcinoma., PMID:40211365
Targeting the undruggable MYC in cancer: the rationale of using XPO1 inhibitors., PMID:40214838
KLF15 regulates macrophage polarization patterns in deep vein thrombosis., PMID:40215780
Integrated Proteomics and Metabolomics Analyses Reveal Molecular Mechanism of Cardiac Resynchronization Therapy Against Cardiac Fibrosis and Ventricular Arrhythmias., PMID:40220080
The Effect of Valine on the Synthesis of α-Casein in MAC-T Cells and the Expression and Phosphorylation of Genes Related to the mTOR Signaling Pathway., PMID:40243924
Belt Electrode-Skeletal Muscle Electrical Stimulation Prevents Muscle Atrophy in the Soleus of Collagen-Induced Arthritis Rats., PMID:40244146
Animal studies reveal downregulation of the Beclin-1 autophagy pathway as shared mechanism in Autism Spectrum Disorder: a systematic review and meta-analysis., PMID:40247126
A kinase-independent Bcr-Abl function mediating an Hsp70-Bim protein-protein interaction in chronic myeloid leukemia., PMID:40250683
Potential therapeutic targets of eukaryotic translation initiation factors in tumor therapy., PMID:40273663
Dual MNK/VEGFR2 Inhibitor JDB153 Enhances Immunotherapeutic Efficiency and Chemosensitivity in Lung Cancer., PMID:40308810
Genetic Evidence Supporting a Causal Association Between mTORC1-Dependent Circulating Protein Levels and Diabetic Retinopathy., PMID:40314641
The nucleocapsid protein of Crimean-Congo hemorrhagic fever virus interacts with eIF4A to promote the translation of viral mRNA in cells., PMID:40328362
Discovery of P11-2: A Potent First-in-Class MNK1-Targeting PROTAC Degrader for the Treatment of Cancer., PMID:40334145
[Oxocrebanine inhibits proliferation of hepatoma HepG2 cells by inducing apoptosis and autophagy]., PMID:40350949
EIF4E promotes gefitinib resistance in non-small cell lung cancer by activating the Wnt/β-catenin pathway., PMID:40353628
From lichen to organoids: Usnic acid enantiomers show promise against Cholangiocarcinoma via MNK2 targeting and MAPK pathway modulation., PMID:40412357
Defective autophagy in a fibroin secretion-deficient silkworm mutant., PMID:40413758
Identification of single nucleotide polymorphisms (SNPs) associated with heat stress and milk production traits in Chinese holstein cows., PMID:40419962
Acyclic Retinoid Overcomes Vemurafenib Resistance in Melanoma Cells via Dual Inhibition of MAPK and PI3K/AKT/mTOR Pathways., PMID:40425334
Guanidinoacetic Acid and Methionine Supplementation Improve the Growth Performance of Beef Cattle via Regulating the Antioxidant Levels and Protein and Lipid Metabolisms in Serum and Liver., PMID:40427441
Neuronal potassium channel activity triggers initiation of mRNA translation through binding of translation regulators., PMID:40435242
Gasdermin D-Mediated Pyroptosis Exerts Two Opposite Effects of Resisting Enzymatic Digestion and Expanding Inflammatory Response in Acute Pancreatitis., PMID:40439590
Condensate-forming eIF4ET ensures adequate levels of meiotic proteins to support oocyte storage., PMID:40441896
4E-BP1-dependent translation in microglia controls mechanical hypersensitivity in male and female mice., PMID:40454470
Identify the co-expressed genes of hypertensive nephropathy and diabetic nephropathy., PMID:40461634
Multipurpose RNA maturation factors dysregulate multiple mRNA processing steps simultaneously and provide new therapeutic opportunities., PMID:40485569
For research use only. Not for human or drug use.
