Catalog No.
FHH31810
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
Neurotrophic tyrosine kinase receptor type 2, TrkB tyrosine kinase, GP145-TrkB, TRKB, NTRK2, Tropomyosin-related kinase B, BDNF/NT-3 growth factors receptor, Trk-B
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q16620
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0477
Immunotherapy against tau fragment diminishes AD pathology, improving synaptic function and cognition., PMID:40426267
Cetuximab and Paclitaxel Drug Response in Head and Neck Tumor Stem Cells., PMID:40149887
Comparative Radiotracing Quantifies Brain Cellular Uptake and Catabolism of Bispecific Antibodies Targeting Transferrin Receptor and CD98hc., PMID:40071777
Spitz Spindle Cell/Reed Nevus With SQSTM1 :: NTRK2 Fusion and Atypical Features in an Older Male Patient: A Case Report and Review of Literature., PMID:39980385
A peptide encoded by upstream open reading frame of MYC binds to tropomyosin receptor kinase B and promotes glioblastoma growth in mice., PMID:39356747
Developing a novel neutralizing monoclonal antibody against TrkB., PMID:39247456
Targeting NGF but not VEGFR1 or BDNF signaling reduces endometriosis-associated pain in mice., PMID:39142441
BDNF/TrkB signalling, in cooperation with muscarinic signalling, retrogradely regulates PKA pathway to phosphorylate SNAP-25 and Synapsin-1 at the neuromuscular junction., PMID:39044222
Targeting TrkB-PSD-95 coupling to mitigate neurological disorders., PMID:38886937
A Four-Week High-Fat Diet Induces Anxiolytic-like Behaviors through Mature BDNF in the mPFC of Mice., PMID:38672038
TrkB-BDNF Signalling and Arc/Arg3.1 Immediate Early Genes in the Anterior Cingulate Cortex and Hippocampus: Insights into Novel Memory Milestones Through Behavioural Tagging., PMID:38485841
Localization of truncated TrkB and co-expression with full-length TrkB in the cerebral cortex of adult mice., PMID:38335799
Genetic knockout of NTRK2 by CRISPR/Cas9 decreases neurogenesis and favors glial progenitors during differentiation of neural progenitor stem cells., PMID:38161998
Sensory innervation of masseter, temporal and lateral pterygoid muscles in common marmosets., PMID:38155190
Obligatory role of microglia-mobilized hippocampal CREB-BDNF signaling in the prophylactic effect of β-glucan on chronic stress-induced depression-like behaviors in mice., PMID:38142848
Distinctive mesenchymal-like neurofibroma stem cells shape NF1 clinical phenotypes controlled by BDNF microenvironment., PMID:38042136
The role of hypoxia and radiation in developing a CTCs-like phenotype in murine osteosarcoma cells., PMID:38033871
Bispecific antibody shuttles targeting CD98hc mediate efficient and long-lived brain delivery of IgGs., PMID:37890480
The efficacy of a TrkB monoclonal antibody agonist in preserving the auditory nerve in deafened guinea pigs., PMID:37837701
Are TrkB receptor agonists the right tool to fulfill the promises for a therapeutic value of the brain-derived neurotrophic factor?, PMID:37488840
Neuroprotective and Disease-Modifying Effects of the Triazinetrione ACD856, a Positive Allosteric Modulator of Trk-Receptors for the Treatment of Cognitive Dysfunction in Alzheimer's Disease., PMID:37446337
Downregulation of BDNF-TrkB signaling may contribute to the colonic motility disorders in mice with streptozocin-induced diabetes., PMID:37417388
Regulation of Satiety by Bdnf-e2-Expressing Neurons through TrkB Activation in Ventromedial Hypothalamus., PMID:37238691
Isolation of human pluripotent stem cell-derived sensory neuron subtypes by immunopanning., PMID:37206924
Redefining Autoimmune Disorders' Pathoetiology: Implications for Mood and Psychotic Disorders' Association with Neurodegenerative and Classical Autoimmune Disorders., PMID:37174637
Bispecific antibody shuttles targeting CD98hc mediate efficient and long-lived brain delivery of IgGs., PMID:37162883
Frequent Overexpression of HER3 in Brain Metastases from Breast and Lung Cancer., PMID:37036472
Nerve growth factor promotes differentiation and protects the oligodendrocyte precursor cells from in vitro hypoxia/ischemia., PMID:36875668
EA participates in pain transition through regulating KCC2 expression by BDNF-TrkB in the spinal cord dorsal horn of male rats., PMID:36875547
Sensory innervation of masseter, temporal and lateral pterygoid muscles in common marmosets., PMID:36798270
Mechanistic study of Coriandrum sativum on neuritogenesis and synaptogenesis based on computationally guided in vitro analyses., PMID:36641106
Neuroprotective effect of secukinumab against rotenone induced Parkinson's disease in rat model: Involvement of IL-17, HMGB-1/TLR4 axis and BDNF/TrKB cascade., PMID:36527875
New, potent, small molecule agonists of tyrosine kinase receptors attenuate dry eye disease., PMID:36091713
[Analgesic effect and mechanism of electroacupuncture on SNI rats based on microglia-BDNF-neuron signal]., PMID:36075600
ERK1/2-dependent BDNF synthesis and signaling is required for the antidepressant effect of microglia stimulation., PMID:35995236
A Single Domain Shark Antibody Targeting the Transferrin Receptor 1 Delivers a TrkB Agonist Antibody to the Brain and Provides Full Neuroprotection in a Mouse Model of Parkinson's Disease., PMID:35890231
Actions of the TrkB Agonist Antibody ZEB85 in Regulating the Architecture and Synaptic Plasticity in Hippocampal Neurons., PMID:35845610
Corticosterone antagonist or TrkB agonist attenuates schizophrenia-like behavior in a mouse model combining Bdnf-e6 deficiency and developmental stress., PMID:35789832
Effects of Excessive Iodine on the BDNF-TrkB Signaling Pathway and Related Genes in Offspring of EAT Rats., PMID:35322353
Body Weight-Supported Treadmill Training Ameliorates Motoneuronal Hyperexcitability by Increasing GAD-65/67 and KCC2 Expression via TrkB Signaling in Rats with Incomplete Spinal Cord Injury., PMID:35320460
Tools for analysis and conditional deletion of subsets of sensory neurons., PMID:35233469
TrkB agonist antibody ameliorates fertility deficits in aged and cyclophosphamide-induced premature ovarian failure model mice., PMID:35177657
Involvement of the BDNF-TrkB-KCC2 pathway in neuropathic pain after brachial plexus avulsion., PMID:35106976
Identification of TrkB Binders from Complex Matrices Using a Magnetic Drug Screening Nanoplatform., PMID:35006910
Environmental Enrichment Induces Meningeal Niche Remodeling through TrkB-Mediated Signaling., PMID:34638999
Localization of Neurotrophin Specific Trk Receptors in Mechanosensory Systems of Killifish (Nothobranchius guentheri)., PMID:34638748
Identification of Trigeminal Sensory Neuronal Types Innervating Masseter Muscle., PMID:34580157
The brain-derived neurotrophic factor prompts platelet aggregation and secretion., PMID:34546355
Infralimbic BDNF signaling is necessary for the beneficial effects of extinction on set shifting in stressed rats., PMID:34497360
ProBDNF Dependence of LTD and Fear Extinction Learning in the Amygdala of Adult Mice., PMID:34470044
For research use only. Not for human or drug use.
