Catalog No.
FHG78910
Species reactivity
Human
Host species
Mouse
Isotype
IgG1
Clonality
Monoclonal
Conjugation
Unconjugated
Target
AXLLG, Growth arrest-specific protein 6, AXL receptor tyrosine kinase ligand, GAS6, GAS-6
Concentration
0.74 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q14393
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0476
Electrochemical immunosensing for rapid glaucoma disease diagnosis through simultaneous determination of SPP1 and GAS6 proteins in ocular fluids., PMID:40494269
Vitamin K supports TGF-β1 depended in vitro human Langerhans cell differentiation and function via Axl., PMID:40040711
Phosphatidylserine (PS)-targeting chimeric Interferon (IFN) fusion proteins for anti-tumor applications., PMID:39896467
Stress-experienced monocytes/macrophages lose anti-inflammatory function via β2-adrenergic receptor in skin allergic inflammation., PMID:39566608
AXL-specific single domain antibodies show diagnostic potential and anti-tumor activity in Acute Myeloid Leukemia., PMID:38773967
CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis., PMID:38166463
Targeting GAS6/AXL signaling improves the response to immunotherapy by restoring the anti-immunogenic tumor microenvironment in gastric cancer., PMID:37952835
Altered expression of AXL receptor tyrosine kinase in gastrointestinal cancers: a promising therapeutic target., PMID:37469409
A procedure for producing an anti-AXL nanobody in E. coli., PMID:37023993
AXL Inhibitors: Status of Clinical Development., PMID:36920638
Microbiota-dependent and -independent postnatal development of salivary immunity., PMID:36640306
Anti-inflammatory clearance of amyloid-β by a chimeric Gas6 fusion protein., PMID:35927581
AXL targeting by a specific small molecule or monoclonal antibody inhibits renal cell carcinoma progression in an orthotopic mice model., PMID:34877810
Interruption of neutrophil extracellular traps formation dictates host defense and tubular HOXA5 stability to augment efficacy of anti-Fn14 therapy against septic AKI., PMID:34646379
AXL Receptor in Cancer Metastasis and Drug Resistance: When Normal Functions Go Askew., PMID:34638349
Tuo-Min-Ding-Chuan Decoction Alleviate Ovalbumin-Induced Allergic Asthma by Inhibiting Mast Cell Degranulation and Down-Regulating the Differential Expression Proteins., PMID:34630102
Anti-Axl monoclonal antibodies attenuate the migration of MDA-MB-231 breast cancer cells., PMID:34539853
Advances in the treatment of platinum resistant epithelial ovarian cancer: an update on standard and experimental therapies., PMID:34082614
Biparatopic single-domain antibodies against Axl achieve ultra-high affinity through intramolecular engagement., PMID:34058562
Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages., PMID:34035216
MERTK Inhibition: Potential as a Treatment Strategy in EGFR Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer., PMID:33562150
Systemic inflammation is a determinant of outcomes of CD40 agonist-based therapy in pancreatic cancer patients., PMID:33497362
TAM receptors: A phosphatidylserine receptor family and its implications in viral infections., PMID:33234246
Anti-Axl antibody treatment reduces the severity of experimental autoimmune encephalomyelitis., PMID:33121494
Selective Increment of Synovial Soluble TYRO3 Correlates with Disease Severity and Joint Inflammation in Patients with Rheumatoid Arthritis., PMID:32964059
CD14+CD16- monocytes are the main precursors of osteoclasts in rheumatoid arthritis via expressing Tyro3TK., PMID:32958023
Gas6 Induces Myelination through Anti-Inflammatory IL-10 and TGF-β Upregulation in White Matter and Glia., PMID:32722558
Interaction with CD68 and Regulation of GAS6 Expression by Endosialin in Fibroblasts Drives Recruitment and Polarization of Macrophages in Hepatocellular Carcinoma., PMID:32591411
Heme oxygenase-1 inhibition mediates Gas6 to enhance bortezomib-sensitivity in multiple myeloma via ERK/STAT3 axis., PMID:32298237
Possible Association of Elevated Plasma Levels of Growth Arrest-Specific Protein 6 and the Soluble Form of Tyrosine Kinase Receptor Axl with Low Hepatitis C Viral Load in Patients with Type 2 Diabetes Mellitus., PMID:31905327
AXL receptor tyrosine kinase as a promising anti-cancer approach: functions, molecular mechanisms and clinical applications., PMID:31684958
Increased sMer, but not sAxl, sTyro3, and Gas6 relate with active disease in juvenile systemic lupus erythematosus., PMID:31655933
Target-Mediated Drug Disposition Pharmacokinetic/Pharmacodynamic Model-Informed Dose Selection for the First-in-Human Study of AVB-S6-500., PMID:31599479
Macrophage phenotypes and Gas6/Axl signaling in apical lesions., PMID:31528256
Regulatory T-cells regulate neonatal heart regeneration by potentiating cardiomyocyte proliferation in a paracrine manner., PMID:31285764
Engineered AXL-ECD-Fc variants that abolish the AXL/Gas6 interaction suppress tumor cell migration., PMID:31186805
Growth arrest-specific protein 6 (Gas6) attenuates inflammatory injury and apoptosis in iodine-induced NOD.H-2h4 mice., PMID:31129420
A novel human anti-AXL monoclonal antibody attenuates tumour cell migration., PMID:31075180
Pan-TAM Tyrosine Kinase Inhibitor BMS-777607 Enhances Anti-PD-1 mAb Efficacy in a Murine Model of Triple-Negative Breast Cancer., PMID:30877108
Differential Interaction of Platelet-Derived Extracellular Vesicles With Circulating Immune Cells: Roles of TAM Receptors, CD11b, and Phosphatidylserine., PMID:30619243
Tyro3, Axl, and Mertk receptors differentially participate in platelet activation and thrombus formation., PMID:30541554
Targeted inhibition of Axl receptor tyrosine kinase ameliorates anti-GBM-induced lupus-like nephritis., PMID:29895432
Proseek single-plex protein assay kit system to detect sAxl and Gas6 in serological material of brain tumor patients., PMID:29876303
Targeting of TAM Receptors Ameliorates Fibrotic Mechanisms in Idiopathic Pulmonary Fibrosis., PMID:29634284
Axl and MerTK receptor tyrosine kinases maintain human macrophage efferocytic capacity in the presence of viral triggers., PMID:29400409
Antiphospholipid Antibodies Inhibit Trophoblast Toll-Like Receptor and Inflammasome Negative Regulators., PMID:29342502
Inhibition of type I interferon responses by adenovirus serotype-dependent Gas6 binding., PMID:29288958
A critical role of Gas6/Axl signal in allergic airway responses during RSV vaccine-enhanced disease., PMID:28722020
Gas6 Promotes Inflammatory (CCR2hiCX3CR1lo) Monocyte Recruitment in Venous Thrombosis., PMID:28450294
Axl acts as a tumor suppressor by regulating LIGHT expression in T lymphoma., PMID:28423548
For research use only. Not for human or drug use.
