Catalog No.
FHE55410
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
Intercrine reduced in hepatomas, hSDF-1, Stromal cell-derived factor 1, SDF-1, Pre-B cell growth-stimulating factor, SDF1, SDF1A, C-X-C motif chemokine 12, SDF1B, CXCL12, IRH, PBSF, hIRH
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P48061
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0467
Increased Fascin1 and Pak1 Expressions Enhance Age-Associated B-Cell Actin Cytoskeleton Remodeling and Motility., PMID:40500987
Gold-silica hybrid nanolabels decorated with recognition and signaling bioreagents for enhanced electrochemical immunodetection of chemokine ligand-12 in colorectal cancer early diagnosis and monitoring., PMID:40425890
Physical exercise promotes white matter repair after ischemic stroke., PMID:40313089
Plasma Exchange vs. Immunoadsorption: Effects on Immunological Markers and Predictive Value in Steroid-Refractory MS Attacks., PMID:40292037
Corrigendum to "CXCL12 derived from CD248-expressing cancer-associated fibroblasts mediates M2-polarized macrophages to promote nonsmall cell lung cancer progression" [Biochim. Biophys. Acta Mol. Basis Dis., 1868 (2022) 166521-166521/10.1016/j.bbadis.2022.166521]., PMID:40287323
Single-cell sequencing reveals intracranial microvasculature-derived CXCL12 promotes CD8+ T-cell infiltration and blood-brain barrier dysfunction after subarachnoid hemorrhage in mice., PMID:40270006
CXCR4 Inhibition Enhances the Efficacy of CD19 Monoclonal Antibody-Mediated Extermination of B-Cell Lymphoma., PMID:40076664
Blockade of TSP-1/CD47 signal axis promotes donor hematopoietic engraftment by improving SEC/MK niche function., PMID:40060904
Distinct mural cells and fibroblasts promote pathogenic plasma cell accumulation in idiopathic pulmonary fibrosis., PMID:39978854
Research progress in bifunctional small molecules for cancer immunotherapy., PMID:39919914
Nanoparticles containing intracellular proteins modulate neutrophil functional and phenotypic heterogeneity., PMID:39911575
Effectiveness and cytokine profile of combined anti-vascular endothelial growth factor and corticosteroid therapy for chronic retinal vein occlusion., PMID:39825912
Differential Expression of CXCL12 in Human and Mouse Hair: Androgens Induce CXCL12 in Human Dermal Papilla and Dermal Sheath Cup., PMID:39795953
The impact of bevacizumab intraperitoneal perfusion combined with paclitaxel and platinum-based chemotherapy on serum stromal-derived factor-1α (SDF-1α) and chemokine ligand 5 (CXCL-5) levels in patients with ovarian cancer after tumor cell debulking surgery., PMID:39757759
Involvement of CXCL12/CXCR4 in CB2 receptor agonist-attenuated morphine tolerance in Walker 256 tumor-bearing rats with cancer pain., PMID:39696656
CXCL12-Targeted Immunomodulatory Gene Therapy Reduces Radiation-Induced Fibrosis in Healthy Tissues., PMID:39666014
Elevated plasma CXCL12 leads to pain chronicity via positive feedback upregulation of CXCL12/CXCR4 axis in pain synapses., PMID:39627724
Modeling Lymphoma Angiogenesis, Lymphangiogenesis, and Vessel Co-Option, and the Effects of Inhibition of Lymphoma-Vessel Interactions with an αCD20-EndoP125A Antibody Fusion Protein., PMID:39594584
Human immune organoids to decode B cell response in healthy donors and patients with lymphoma., PMID:39506098
Humanized CXCL12 antibody delays onset and modulates immune response in alopecia areata mice: insights from single-cell RNA sequencing., PMID:39483478
CXCL12/CXCR4 Axis Promotes the Chemotaxis and Phagocytosis of B Cells through the PI3K-AKT Signaling Pathway in an Early Vertebrate., PMID:39441360
Human mesenchymal stroma/stem-like cell-derived taxol-loaded EVs/exosomes transfer anti-tumor microRNA signatures and express enhanced SDF-1-mediated tumor tropism., PMID:39420354
Enriched environment enhances angiogenesis in ischemic stroke through SDF-1/CXCR4/AKT/mTOR pathway., PMID:39396564
Lipid rafts, caveolae, and epidermal growth factor receptor family: friends or foes?, PMID:39394159
CXCL12+ tumor-associated endothelial cells promote immune resistance in hepatocellular carcinoma., PMID:39393439
Effect of tocilizumab on endothelial and platelet-derived CXC-chemokines and their association with inflammation and myocardial injury in STEMI patients undergoing primary PCI., PMID:39374793
Sphingosine-1-phosphate receptor type 4 is critically involved in the regulation of peritoneal B-1 cell trafficking and distribution in vivo., PMID:39344245
Structural insights into CXCR4 modulation and oligomerization., PMID:39313635
NK/DC crosstalk-modulating antitumor activity via Sema3E/PlexinD1 axis for enhanced cancer immunotherapy., PMID:39235526
Multivalent CXCR4-targeting nanobody formats differently affect affinity, receptor clustering, and antagonism., PMID:39098732
Investigational CXCR4 inhibitors in early phase development for the treatment of hematological malignancies., PMID:39096094
Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites., PMID:39053189
Interleukin-17A Promotes Airway Remodeling in Chronic Obstructive Pulmonary Disease by Activating C-X-C Motif Chemokine Ligand 12 Secreted by Lung Fibroblasts., PMID:39012715
Modeling of Blood-Brain Barrier (BBB) Dysfunction and Immune Cell Migration Using Human BBB-on-a-Chip for Drug Discovery Research., PMID:38928202
Neointimal hyperplasia after endoluminal injury in mice is dependent on tissue factor- and angiopoietin-2 dependent interferon gamma production by fibrocytes and macrophages., PMID:38911855
Cytokine Levels in Experimental Branch Retinal Vein Occlusion Treated With Either Bevacizumab or Triamcinolone Acetonide., PMID:38899953
CXCR7 activation evokes the anti-PD-L1 antibody against glioblastoma by remodeling CXCL12-mediated immunity., PMID:38898023
Discovery of novel CXCR4 inhibitors for the treatment of inflammation by virtual screening and biological evaluation., PMID:38885550
Neutrophils disrupt B-1a cell homeostasis by targeting Siglec-G to exacerbate sepsis., PMID:38789529
Synergistic effects of Ω-3 polyunsaturated fatty acid supplementation and programmed cell death protein 1 blockade on tumor growth and immune modulation in a xenograft model of esophageal cancer., PMID:38777449
Clostridioides difficile toxin B subverts germinal center and antibody recall responses by stimulating a drug-treatable CXCR4-dependent mechanism., PMID:38761377
Activin A, a Novel Chemokine, Induces Mouse NK Cell Migration via AKT and Calcium Signaling., PMID:38727264
Targeting SIGLEC15 as an emerging immunotherapy for anaplastic thyroid cancer., PMID:38652971
Presence of immunoglobulin E-expressing antibody-secreting cells in the dermis close to bullous pemphigoid lesions., PMID:38590080
The nanobody targeting PD-L1 and CXCR4 counteracts pancreatic stellate cell-mediated tumour progression by disrupting tumour microenvironment., PMID:38581990
CXCR4: from B-cell development to B cell-mediated diseases., PMID:38519141
Regulatory T cell-derived exosome mediated macrophages polarization for osteogenic differentiation in fracture repair., PMID:38508525
Extracellular metallothionein as a therapeutic target in the early progression of type 1 diabetes., PMID:38490439
Research progress of the chemokine/chemokine receptor axes in the oncobiology of multiple myeloma (MM)., PMID:38475811
SDF-1 involvement in orthodontic tooth movement after tooth extraction., PMID:38424199
For research use only. Not for human or drug use.
