Catalog No.
FHC01810
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
C-X-C motif chemokine 4, PF-4, Oncostatin-A, Endothelial cell growth inhibitor, CXCL4, Iroplact, Platelet factor 4, PF4, SCYB4
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P02776
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0463
Circulating Levels of PF4/CXCL4 in Patients With BCR::ABL1-Negative Myeloproliferative Neoplasms: A New Potential Prognostic Factor for Disease Progression., PMID:40221885
Correction: Proteomic screening identifies PF4/Cxcl4 as a critical driver of myelofibrosis., PMID:40169764
Platelet Factor 4: A Mysterious Chemokine in Inflammatory Regulation Diseases., PMID:40166592
The Role of CXCL4 in Systemic Sclerosis: DAMP, Auto-Antigen and Biomarker., PMID:40141068
Platelet-activating cytokines potentially associated with MASLD-induced liver injury significantly decreased following CPAP therapy: A translational study using a fatty liver mouse model., PMID:40112616
Decreased serum PF4 levels correlate with cognitive decline and CSF biomarkers in Alzheimer's disease in a Chinese cohort., PMID:39855320
Efferocytosis dysfunction in CXCL4-induced M4 macrophages: phenotypic insights in systemic sclerosis in vitro and in vivo., PMID:39464886
Type 2-like polarization and elevated CXCL4 secretion of monocyte derived macrophages upon internalization of plasma-derived exosomes from head and neck cancer patients., PMID:39304856
Retinal perivascular macrophages regulate immune cell infiltration during neuroinflammation in mouse models of ocular disease., PMID:39207852
Proteomic screening identifies PF4/Cxcl4 as a critical driver of myelofibrosis., PMID:39025985
Serglycin controls megakaryocyte retention of platelet factor 4 and influences megakaryocyte fate in bone marrow., PMID:38941534
Hyperactivation of β-catenin signal in hepatocellular carcinoma recruits myeloid-derived suppressor cells through PF4-CXCR3 axis., PMID:38307410
Platelet factor 4 limits neutrophil extracellular trap- and cell-free DNA-induced thrombogenicity and endothelial injury., PMID:37991024
Platelet factor 4 improves survival in a murine model of antibiotic-susceptible and methicillin-resistant Staphylococcus aureus peritonitis., PMID:37868353
Virtual Screening of Protein Data Bank via Docking Simulation Identified the Role of Integrins in Growth Factor Signaling, the Allosteric Activation of Integrins, and P-Selectin as a New Integrin Ligand., PMID:37759488
PLATELET FACTOR 4 (PF4) IMPROVES SURVIVAL IN A MURINE MODEL OF ANTIBIOTIC-SUSCEPTIBLE AND METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS PERITONITIS., PMID:37662328
The immunology of PF4 polyanion interactions., PMID:37603711
Functions for platelet factor 4 (PF4/CXCL4) and its receptors in fibroblast-myofibroblast transition and fibrotic failure of arteriovenous fistulas (AVFs)., PMID:37589266
Platelet factors attenuate inflammation and rescue cognition in ageing., PMID:37587343
Platelet-derived exerkine CXCL4/platelet factor 4 rejuvenates hippocampal neurogenesis and restores cognitive function in aged mice., PMID:37587147
Antibodies against platelet factor 4 and the risk of cerebral venous sinus thrombosis in patients with vaccine-induced immune thrombotic thrombocytopenia., PMID:37394121
Platelets regulate ischemia-induced revascularization and angiogenesis by secretion of growth factor-modulating factors., PMID:37257194
CXCR2 (rs3890158 and rs2230054) and CXCL4 (rs352008 and rs1801572) gene polymorphisms in patients with thoracic aortic aneurysm., PMID:37154009
Platelet factor 4 triggers thrombo-inflammation by bridging innate and adaptive immunity., PMID:37150909
Altered platelet reactivity, coagulation, endothelial and inflammatory markers early after smoking cessation verified with cotinine plasma concentration., PMID:37138182
New perspectives on the induction and acceleration of immune-associated thrombosis by PF4 and VWF., PMID:36926331
SARS-CoV-2 spike protein promotes inflammatory cytokine activation and aggravates rheumatoid arthritis., PMID:36864432
Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner., PMID:36807143
Neutrophil extracellular trap stabilization by platelet factor 4 reduces thrombogenicity and endothelial cell injury., PMID:36711969
Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors., PMID:36640356
CXCL4-RNA Complexes Circulate in Systemic Sclerosis and Amplify Inflammatory/Pro-Fibrotic Responses by Myeloid Dendritic Cells., PMID:36614095
Platelet factor 4 (CXCL4/PF4) upregulates matrix metalloproteinase-2 (MMP-2) in gingival fibroblasts., PMID:36329090
Role of CXCR3 in fibrotic tissue responses., PMID:36195287
Role of platelet factor 4 in arteriovenous fistula maturation failure: What do we know so far?, PMID:35751379
CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes., PMID:35701499
Chemokine PF4 Inhibits EV71 and CA16 Infections at the Entry Stage., PMID:35579435
Ammonia exposure by intratracheal instillation causes severe and deteriorating lung injury and vascular effects in mice., PMID:35452355
Comprehensive analysis of the expression and significance of CXCLs in human diffuse large B-cell lymphoma., PMID:35181719
Heparin-Functionalized Adsorbents Eliminate Central Effectors of Immunothrombosis, including Platelet Factor 4, High-Mobility Group Box 1 Protein and Histones., PMID:35163743
Production of anti-PF4 antibodies in antiphospholipid antibody-positive patients is not affected by COVID-19 vaccination., PMID:35131751
Differential Effects of Platelet Factor 4 (CXCL4) and Its Non-Allelic Variant (CXCL4L1) on Cultured Human Vascular Smooth Muscle Cells., PMID:35054772
Utility of cytokines CXCL4, CXCL8 and GDF15 as biomarkers in systemic sclerosis., PMID:35039167
Uncomplicated Plasmodium vivax malaria: mapping the proteome from circulating platelets., PMID:34991449
CXCL4 drives fibrosis by promoting several key cellular and molecular processes., PMID:34986347
Chemokines modulate glycan binding and the immunoregulatory activity of galectins., PMID:34931005
Hypoxia and TLR9 activation drive CXCL4 production in systemic sclerosis plasmacytoid dendritic cells via mtROS and HIF-2α., PMID:34559222
Contribution to the peripheral vasculopathy and endothelial cell dysfunction by CXCL4 in Systemic Sclerosis., PMID:34556381
Platelet Activation and Chemokine Release Are Related to Local Neutrophil-Dominant Inflammation During Hyperacute Human Stroke., PMID:34455571
CRISPR/Cas9 mediated CXCL4 knockout in human iPS cells of polycythemia vera patient with JAK2 V617F mutation., PMID:34391098
Rapid Internalization and Nuclear Translocation of CCL5 and CXCL4 in Endothelial Cells., PMID:34298951
For research use only. Not for human or drug use.
