Catalog No.
FHD82310
Species reactivity
Human
Host species
Mouse
Isotype
IgG1, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
IGFBP8, IGF-binding protein 8, IBP-8, CTGF, HCS24, CCN family member 2, CCN2, Cellular communication network factor 2, Hypertrophic chondrocyte-specific protein 24, Connective tissue growth factor, Insulin-like growth factor-binding protein 8, IGFBP-8
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P29279
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0452
A Self-Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple-Negative Breast Cancer Therapy., PMID:40349150
Histopathological and molecular analysis in dermis and epidermis of patients with systemic and localized scleroderma., PMID:40330524
CTGF (CCN2): a multifaceted mediator in breast cancer progression and therapeutic targeting., PMID:39945880
Effects of linsitinib on M22 and IGF:1-treated 3D spheroids of human orbital fibroblasts., PMID:39747159
Interleukin-38-overexpressing adenovirus infection in dendritic cell-based treatment enhances immunotherapy for allergic asthma via inducing Foxp3+ regulatory T cells., PMID:39667222
Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2., PMID:39495216
CD248-expressing cancer-associated fibroblasts induce non-small cell lung cancer metastasis via Hippo pathway-mediated extracellular matrix stiffness., PMID:39164826
PAR2 activation on human tubular epithelial cells engages converging signaling pathways to induce an inflammatory and fibrotic milieu., PMID:39005931
Multimodal Imaging-Assisted Intravascular Theranostic Photoactivation on Atherosclerotic Plaque., PMID:38989585
Mechanical stress-induced connective tissue growth factor plays a critical role in intestinal fibrosis in Crohn's-like colitis., PMID:38954823
Effect of antibody-mediated connective tissue growth factor neutralization on lung edema in ventilator-induced lung injury in rats., PMID:38778274
In a novel autoimmune and high-pressure glaucoma model a complex immune response is induced., PMID:38515755
Distinct distribution of subplate neuron subtypes between the sensory cortices during the early postnatal period., PMID:38407509
The pathogenic role of succinate-SUCNR1: a critical function that induces renal fibrosis via M2 macrophage., PMID:38291510
Tyrosine phosphorylation-mediated YAP1-TFAP2A interactions coordinate transcription and trastuzumab resistance in HER2+ breast cancer., PMID:38219531
Serum level of full-length connective tissue growth factor reflects liver fibrosis stage in patients with Fontan-associated liver disease., PMID:38166061
CTGF regulates mineralization in human mature chondrocyte by controlling Pit-1 and modulating ANK via the BMP/Smad signalling., PMID:38134555
Biomarkers in Systemic Sclerosis: An Overview., PMID:37886934
Biomarkers in the Pathogenesis, Diagnosis, and Treatment of Systemic Sclerosis., PMID:37868834
An up-to-date review of approved and emerging antibody therapies for idiopathic pulmonary fibrosis., PMID:37797203
Blocking CCN2 Reduces Established Palmar Neuromuscular Fibrosis and Improves Function Following Repetitive Overuse Injury., PMID:37762168
Extracellular Matrix Stiffness Regulates Microvascular Stability by Controlling Endothelial Paracrine Signaling to Determine Pericyte Fate., PMID:37650330
IL-25 induces airway remodeling in asthma by orchestrating the phenotypic changes of epithelial cell and fibrocyte., PMID:37635231
Knockdown of KLF5 ameliorates renal fibrosis in MRL/lpr mice via inhibition of MX1 transcription., PMID:37506140
Pamrevlumab, a Fully Human Monoclonal Antibody Targeting Connective Tissue Growth Factor, for Non-Ambulatory Patients with Duchenne Muscular Dystrophy., PMID:37248912
A fully human connective tissue growth factor blocking monoclonal antibody ameliorates experimental rheumatoid arthritis through inhibiting angiogenesis., PMID:36869335
The Inhibitory Effect of Connective Tissue Growth Factor Antibody on Postoperative Fibrosis in a Rabbit Model of Trabeculectomy., PMID:36620705
Endothelial cell‑derived connective tissue growth factor stimulates fibroblast differentiation into myofibroblasts through integrin αVβ3., PMID:36561611
Serum IL-12p40: A novel biomarker for early prediction of minimal change disease relapse following glucocorticoids therapy., PMID:36507530
Angiogenesis Assays for the Analysis of CCN Proteins., PMID:36370358
CTGF as a multifunctional molecule for cartilage and a potential drug for osteoarthritis., PMID:36325449
Phenytoin induces connective tissue growth factor (CTGF/CCN2) production through NADPH oxidase 4-mediated latent TGFβ1 activation in human gingiva fibroblasts: Suppression by curcumin., PMID:36205057
Multifunctional regulatory protein connective tissue growth factor (CTGF): A potential therapeutic target for diverse diseases., PMID:35847511
Vaccination against connective tissue growth factor attenuates the development of renal fibrosis., PMID:35768626
Interference with connective tissue growth factor attenuated fibroblast-to-myofibroblast transition and pulmonary fibrosis., PMID:35722387
1,25OH-Vitamin D3 and IL-17 Inhibition Modulate Pro-Fibrotic Cytokines Production in Peripheral Blood Mononuclear Cells of Patients with Systemic Sclerosis., PMID:35693738
Oxygen Desaturation Is Associated With Fibrocyte Activation via Epidermal Growth Factor Receptor/Hypoxia-Inducible Factor-1α Axis in Chronic Obstructive Pulmonary Disease., PMID:35634326
Tubular cells produce FGF2 via autophagy after acute kidney injury leading to fibroblast activation and renal fibrosis., PMID:35491858
A Monoclonal Anti-HMGB1 Antibody Attenuates Neurodegeneration in an Experimental Animal Model of Glaucoma., PMID:35456925
IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis., PMID:35408908
The efficacy and safety of intravitreal injection of Ranibizumab as pre-treatment for vitrectomy in proliferative diabetic retinopathy with vitreous hemorrhage., PMID:35139812
Evidence of telomere attrition and a potential role for DNA damage in systemic sclerosis., PMID:35086525
Hepatocyte growth factor exhibits anti-fibrotic effects in an in vitro model of nifedipine-induced gingival overgrowth., PMID:34980825
Soluble very low-density lipoprotein receptor (sVLDLR) inhibits fibrosis in neovascular age-related macular degeneration., PMID:34820908
Connective-Tissue Growth Factor Contributes to TGF-β1-induced Lung Fibrosis., PMID:34797990
The protective effects of pericyte-derived microvesicles on vascular endothelial functions via CTGF delivery in sepsis., PMID:34784912
ERK and p38 MAPK inhibition controls NF-E2 degradation and profibrotic signaling in renal proximal tubule cells., PMID:34715142
Endothelial cell-derived pro-fibrotic factors increase TGF-β1 expression by smooth muscle cells in response to cycles of hypoxia-hyperoxia., PMID:34601016
Activated Alpha 2-Macroglobulin Is a Novel Mediator of Mesangial Cell Profibrotic Signaling in Diabetic Kidney Disease., PMID:34572299
Targeting REG3β limits pancreatic ductal adenocarcinoma progression through CTGF downregulation., PMID:34450197
For research use only. Not for human or drug use.
