Catalog No.
FHC42110
Species reactivity
Human
Host species
Mouse
Isotype
IgG2a, kappa
Clonality
Monoclonal
Conjugation
Unconjugated
Target
CSF1, Macrophage colony-stimulating factor 1, CSF-1, Lanimostim, M-CSF, MCSF
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P09603
Applications
ELISA, FCM
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.09% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA0417
Harnessing local and system immune profiling delineating differential responders to first-line sintilimab (anti-PD-1 antibody) combined with chemotherapy in extensive-stage small cell lung cancer: an exploratory biomarker analysis of a phase II study., PMID:40404633
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Axatilimab in Healthy Japanese Male Participants: Results from a Phase 1, Randomized, Double-Blind, Dose-Escalation Study., PMID:40381116
Evaluating Axatilimab as a treatment option for chronic graft-versus-host disease., PMID:40338737
New soluble CSF-1R-dimeric mutein with enhanced trapping of both CSF-1 and IL-34 reduces suppressive tumor-associated macrophages in pleural mesothelioma., PMID:40101804
Intravitreal delivery of NMO-IgG causes primary retinal damage in the absence of optic nerve injury., PMID:40055743
Immunological biomarkers of response and resistance to treatment with cabozantinib and nivolumab in recurrent endometrial cancer., PMID:40010771
Neutrophil extracellular traps impede cancer metastatic seeding via protease-activated receptor 2-mediated downregulation of phagocytic checkpoint CD24., PMID:40010762
Development of antigen-capture enzyme-linked immunoassay for Chicken Interleukin-34., PMID:39900196
Inhibition of the extracellular matrix protein fibulin-3 reduces immunosuppressive signaling in tumor stem cells and increases macrophage activation against glioblastoma., PMID:39763756
Semimechanistic Population PK/PD Modeling of Axatilimab in Healthy Participants and Patients With Solid Tumors or Chronic Graft-Versus-Host Disease., PMID:39704205
Dorsal root ganglia CSF1+ neuronal subtypes have different impact on macrophages and microglia after spared nerve injury., PMID:39581686
The contribution of the monocyte-macrophage lineage to immunotherapy outcomes., PMID:39576958
Identification of microenvironment features associated with primary resistance to anti-PD-1/PD-L1 + antiangiogenesis in gastric cancer through spatial transcriptomics and plasma proteomics., PMID:39272096
CSF1R inhibition by PLX5622 reduces pulmonary fungal infection by depleting MHCIIhi interstitial lung macrophages., PMID:39168451
Pembrolizumab and Cabozantinib in Recurrent and/or Metastatic Head and Neck Squamous Cell Carcinoma: Long-term Survival Update with a Biomarker Analysis., PMID:39167623
L-Wnk1 Deletion in Smooth Muscle Cells Causes Aortitis and Inflammatory Shift., PMID:38979610
Baricitinib ameliorates inflammatory and neuropathic pain in collagen antibody-induced arthritis mice by modulating the IL-6/JAK/STAT3 pathway and CSF-1 expression in dorsal root ganglion neurons., PMID:38879555
Mechanistic Characterization of Cancer-associated Fibroblast Depletion via an Antibody-Drug Conjugate Targeting Fibroblast Activation Protein., PMID:38747612
Phase Ib/II Study of Lacnotuzumab in Combination with Spartalizumab in Patients with Advanced Malignancies., PMID:38721402
Tumor microenvironment restricts IL-10 induced multipotent progenitors to myeloid-lymphatic phenotype., PMID:38640116
The interplay of Cxcl10+/Mmp14+ monocytes and Ccl3+ neutrophils proactively mediates silica-induced pulmonary fibrosis., PMID:38335607
Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial., PMID:38277235
The CSF-1R inhibitor pexidartinib affects FLT3-dependent DC differentiation and may antagonize durvalumab effect in patients with advanced cancers., PMID:38266104
Validation of CSF-1 receptor (CD115) staining for analysis of murine monocytes by flow cytometry., PMID:38038378
A novel monoclonal antibody against porcine macrophage colony-stimulating factor (CSF1) detects expression on the cell surface of macrophages., PMID:37992576
CSF-1 and Notch signaling cooperate in macrophage instruction and tissue repair during peripheral limb ischemia., PMID:37691936
Genetic and Immunohistochemistry Tools to Visualize Rat Macrophages In Situ., PMID:37639117
Blockade of tumor-derived colony-stimulating factor 1 (CSF1) promotes an immune-permissive tumor microenvironment., PMID:37505292
Hemolysis dictates monocyte differentiation via two distinct pathways in sickle cell disease vaso-occlusion., PMID:37490346
Updates on the Treatment of Tenosynovial Giant Cell Tumor., PMID:37363972
Microglia mediate neurocognitive deficits by eliminating C1q-tagged synapses in sepsis-associated encephalopathy., PMID:37235660
Cathepsin C promotes colorectal cancer metastasis by regulating immune escape through upregulating CSF1., PMID:36916928
Commensal Bacteria and the Lung Environment Are Responsible for Th2-Mediated Memory Yielding Natural IgE in MyD88-Deficient Mice., PMID:36883865
Immunosuppression by Inflammation-Stimulated Amplification of Myeloid-Derived Suppressor Cells and Changes in Expression of Immune Checkpoint HHLA2 in Chronic Obstructive Pulmonary Disease., PMID:36846109
Systems biological assessment of the temporal dynamics of immunity to a viral infection in the first weeks and months of life., PMID:36778389
AXL antibody and AXL-ADC mediate antitumor efficacy via targeting AXL in tumor-intrinsic epithelial-mesenchymal transition and tumor-associated M2-like macrophage., PMID:36650292
LncRNA HCG18 promotes M2 macrophage polarization to accelerate cetuximab resistance in colorectal cancer through regulating miR-365a-3p/FOXO1/CSF-1 axis., PMID:36410171
Oocytes could rearrange immunoglobulin production to survive over adverse environmental stimuli., PMID:36405746
Artificial Intelligence Predicted Overall Survival and Classified Mature B-Cell Neoplasms Based on Immuno-Oncology and Immune Checkpoint Panels., PMID:36358737
Diagnostic utility of CSF1 immunohistochemistry in tenosynovial giant cell tumor for differentiating from giant cell-rich tumors and tumor-like lesions of bone and soft tissue., PMID:36320082
Macrophage-Secreted CSF1 Transmits a Calorie Restriction-Induced Self-Renewal Signal to Mammary Epithelial Stem Cells., PMID:36139499
Treatment updates on tenosynovial giant cell tumor., PMID:35837703
Blunt snout bream (Megalobrama amblycephala) MaCSF-1 contributes to proliferation, phagocytosis and immunoregulation of macrophages via MaCSF-1R., PMID:35803511
In vivo multidimensional CRISPR screens identify Lgals2 as an immunotherapy target in triple-negative breast cancer., PMID:35767614
M-CSF-stimulated myeloid cells can convert into epithelial cells to participate in re-epithelialization and hair follicle regeneration during dermal wound healing., PMID:35737933
Development of a sandwich ELISA for the detection of chicken colony-stimulating factor 1., PMID:35688031
Crosstalk between macrophage-derived PGE2 and tumor UHRF1 drives hepatocellular carcinoma progression., PMID:35664070
Clinical Development of Colony-Stimulating Factor 1 Receptor (CSF1R) Inhibitors., PMID:35663534
Molecular and Immune Profiling of Syngeneic Mouse Models Predict Response to Immune Checkpoint Inhibitors in Gastric Cancer., PMID:35609622
Tumor-associated macrophages regulate the function of cytotoxic T lymphocyte through PD-1/PD-L1 pathway in multiple myeloma., PMID:35593325
For research use only. Not for human or drug use.
