InVivoMAb Anti-Human PSCA (Iv0097)

Catalog No.

VHA73501

Species reactivity

Human

Host species

Human

Isotype

IgG1, kappa

Clonality

Monoclonal

Target

Prostate stem cell antigen, PSCA

Concentration

1.85 mg/ml

Endotoxin level

Please contact with the lab for this information.

Purity

>95% as determined by SDS-PAGE.

Purification

Protein A/G purified from cell culture supernatant.

Accession

O43653

Applications

ELISA, Neutralization

Form

Liquid

Storage buffer

0.01M PBS, pH 7.4.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.

Clone ID

Iv0097

A facile yeast-display approach for antibody mask discovery., PMID:40381213

Developing cell-based therapies for pancreatic ductal adenocarcinoma., PMID:40231460

Off-the-shelf invariant NKT cells expressing anti-PSCA CAR and IL-15 promote pancreatic cancer regression in mice., PMID:40231459

Human intermediate prostate cancer stem cells contribute to the initiation and development of prostate adenocarcinoma., PMID:39256886

Prevention of prostate cancer metastasis by a CRISPR-delivering nanoplatform for interleukin-30 genome editing., PMID:39244641

Human anti-PSCA CAR macrophages possess potent antitumor activity against pancreatic cancer., PMID:38663406

Tandem CAR-T cells targeting MUC1 and PSCA combined with anti-PD-1 antibody exhibit potent preclinical activity against non-small cell lung cancer., PMID:37660477

A Model for Gastric Cancer Risk Prediction Based on MUC1 Polymorphisms and Health-risk Behaviors in a Vietnamese Population., PMID:37652501

Preclinical Characterization of the 177Lu-Labeled Prostate Stem Cell Antigen (PSCA)-Specific Monoclonal Antibody 7F5., PMID:37298374

Co-expression of a PD-L1-specific chimeric switch receptor augments the efficacy and persistence of CAR T cells via the CD70-CD27 axis., PMID:36229619

Cryo-electron microscopy structure of the intact photosynthetic light-harvesting antenna-reaction center complex from a green sulfur bacterium., PMID:36125941

Expansion of mouse castration-resistant intermediate prostate stem cells in vitro., PMID:35841025

Development and Functional Characterization of a Versatile Radio-/Immunotheranostic Tool for Prostate Cancer Management., PMID:35454902

Off-the-Shelf Prostate Stem Cell Antigen-Directed Chimeric Antigen Receptor Natural Killer Cell Therapy to Treat Pancreatic Cancer., PMID:34999097

Targeted RNAi of BIRC5/Survivin Using Antibody-Conjugated Poly(Propylene Imine)-Based Polyplexes Inhibits Growth of PSCA-Positive Tumors., PMID:34066833

Engineering Tolerance toward Allogeneic CAR-T Cells by Regulation of MHC Surface Expression with Human Herpes Virus-8 Proteins., PMID:33554868

Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips., PMID:32807988

Evaluation of [131I]I- and [177Lu]Lu-DTPA-A11 Minibody for Radioimmunotherapy in a Preclinical Model of PSCA-Expressing Prostate Cancer., PMID:32661830

Downregulation of PSCA promotes gastric cancer proliferation and is related to poor prognosis., PMID:32201541

PSCA is a target of chimeric antigen receptor T cells in gastric cancer., PMID:32010446

Tri-functional platform for construction of modular antibody fragments for in vivo 18F-PET or NIRF molecular imaging., PMID:34123276

Expanding CAR T cells in human platelet lysate renders T cells with in vivo longevity., PMID:31779709

A PSCA/PGRN-NF-κB-Integrin-α4 Axis Promotes Prostate Cancer Cell Adhesion to Bone Marrow Endothelium and Enhances Metastatic Potential., PMID:31722969

In-vitro prostate cancer biomarker detection by directed conjugation of anti-PSCA antibody to super paramagnetic iron oxide nanoparticless., PMID:31380306

An oligo-His-tag of a targeting module does not influence its biodistribution and the retargeting capabilities of UniCAR T cells., PMID:31332252

DNA vaccination via RALA nanoparticles in a microneedle delivery system induces a potent immune response against the endogenous prostate cancer stem cell antigen., PMID:31299353

A Dual-Modality Linker Enables Site-Specific Conjugation of Antibody Fragments for 18F-Immuno-PET and Fluorescence Imaging., PMID:30877181

Patella tendon moment arm function considerations for human vastus lateralis force estimates., PMID:30736963

Recirculating peritoneal dialysis system using urease-fixed silk fibroin membrane filter with spherical carbonaceous adsorbent., PMID:30678941

Quantum dot-based fluorescent probes for targeted imaging of the EJ human bladder urothelial cancer cell line., PMID:30546399

Near-Infrared Dye-Labeled Anti-Prostate Stem Cell Antigen Minibody Enables Real-Time Fluorescence Imaging and Targeted Surgery in Translational Mouse Models., PMID:30301826

Improved Conjugation, 64-Cu Radiolabeling, in Vivo Stability, and Imaging Using Nonprotected Bifunctional Macrocyclic Ligands: Bis(Phosphinate) Cyclam (BPC) Chelators., PMID:30180567

Anti-Inflammatory Activities and Related Mechanism of Polysaccharides Isolated from Sargentodoxa cuneata., PMID:30153400

PET of Adoptively Transferred Chimeric Antigen Receptor T Cells with 89Zr-Oxine., PMID:29728514

Dual-Modality Immuno-PET and Near-Infrared Fluorescence Imaging of Pancreatic Cancer Using an Anti-Prostate Stem Cell Antigen Cys-Diabody., PMID:29602820

Evaluation of a Pretargeting Strategy for Molecular Imaging of the Prostate Stem Cell Antigen with a Single Chain Antibody., PMID:29491468

Co-stimulatory signaling determines tumor antigen sensitivity and persistence of CAR T cells targeting PSCA+ metastatic prostate cancer., PMID:29308300

Characterization of a switchable chimeric antigen receptor platform in a pre-clinical solid tumor model., PMID:29123951

Multiplex Gene Expression Profiling of In Vivo Isolated Circulating Tumor Cells in High-Risk Prostate Cancer Patients., PMID:29122836

PSCA promotes prostate cancer proliferation and cell-cycle progression by up-regulating c-Myc., PMID:28971496

PSCA regulates IL-6 expression through p38/NF-κB signaling in prostate cancer., PMID:28845520

PSCA and MUC1 in non-small-cell lung cancer as targets of chimeric antigen receptor T cells., PMID:28405515

Incorporation of a hinge domain improves the expansion of chimeric antigen receptor T cells., PMID:28288656

Knockdown of PSCA induces EMT and decreases metastatic potentials of the human prostate cancer DU145 cells., PMID:26981049

Fluorescent Image-Guided Surgery with an Anti-Prostate Stem Cell Antigen (PSCA) Diabody Enables Targeted Resection of Mouse Prostate Cancer Xenografts in Real Time., PMID:26490315

RNA interference targeting PSCA suppresses primary tumor growth and metastasis formation of human prostate cancer xenografts in SCID mice., PMID:26477693

Down-regulation of prostate stem cell antigen (PSCA) by Slug promotes metastasis in nasopharyngeal carcinoma., PMID:26147638

Down-regulation of Immune-related Genes by PSCA in Gallbladder Cancer Cells Implanted into Mice., PMID:25964537

rs2294008T, a risk allele for gastric and gallbladder cancers, suppresses the PSCA promoter by recruiting the transcription factor YY1., PMID:25727947

Forced LIGHT expression in prostate tumors overcomes Treg mediated immunosuppression and synergizes with a prostate tumor therapeutic vaccine by recruiting effector T lymphocytes., PMID:25399517

Document Download

InVivoMAb Anti-Human PSCA (Iv0097).pdf