Catalog No.
VHC97801
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
HC11, MCP-1, MCP1, Monocyte chemotactic protein 1, Monocyte chemotactic and activating factor, Small-inducible cytokine A2, SCYA2, MCAF, Monocyte secretory protein JE, C-C motif chemokine 2, Monocyte chemoattractant protein 1, CCL2
Concentration
2.08 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P13500
Applications
ELISA, FCM, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0077
Obtusifolin mitigates acute lung injury and improves cardio-pulmonary functions in acute lung injury model by modulating oxidative stress and NF-κB signaling., PMID:40493249
Toxoplasma gondii parasites induce a localized myeloid cell immune response surrounding parasites in the brain during acute infection., PMID:40492741
Integration of Network Pharmacology, Transcriptomics, and Metabolomics Strategies to Uncover the Mechanism of Chaihuang Qingfu Pill in Treating Sepsis-Induced Liver Injury., PMID:40486124
Myeloid Glutamine Synthetase Protects Against Acute Liver Injury in Mice Independent of Its Enzyme Activity., PMID:40485395
CCL2/CCR4 participates in mast cell-mediated epithelial mesenchymal transition in endometriosis., PMID:40472665
Integrated profiling of adiponectin and cytokine signaling pathways in high-fat diet-induced MASLD reveals early markers of disease progression., PMID:40467680
The role of immune checkpoint molecules in PRRSV-2-induced immune modulation: insights from comparative in vivo evaluation including NADC34-like PRRSV., PMID:40459260
Engineered macrophage membrane-coated dihydroartemisinin nanoparticles with enhanced CCR2 expression improved symptoms in MRL/LPR mice by metabolic reprogramming of proinflammatory macrophages., PMID:40457421
In silico prediction of differentially expressed genes and functionally grouped networks in patients with inflamed pulp for screening pulpitis biomarkers., PMID:40453410
Defining neuronal responses to the neurotropic parasite Toxoplasma gondii., PMID:40444956
Wogonin inhibits the proliferation of prolactinoma through the PI3K/AKT signaling pathway., PMID:40444042
Inhibition of MCP1 (CCL2) Enhances Antitumor Activity of NK Cells Against HCC Cells Under Hypoxia., PMID:40430040
Comparative Analysis of Cytokine Expression Profiles in Prostate Cancer Patients., PMID:40427694
Role of lncRNA Xist-miR-124-CCL2 axis in HIV Tat-mediated microglial activation and neuroinflammation., PMID:40406114
POSTN Silencing Ameliorates LL37-Induced Rosacea and Inhibits the JAK2/STAT3 and NF-κB Pathways., PMID:40387439
Osteosarcoma cell-derived CCL2 facilitates lung metastasis via accumulation of tumor-associated macrophages., PMID:40343498
Decreased OGT Attenuates Endometrial Decidualization and Embryo Implantation by Affecting HIF-1α Stability., PMID:40342239
EYA3 regulation of NF-κB and CCL2 suppresses cytotoxic NK cells in the premetastatic niche to promote TNBC metastasis., PMID:40333987
HIF-1α-Induced GPR171 Expression Mediates CCL2 Secretion by Mast Cells to Promote Gastric Inflammation During Helicobacter pylori Infection., PMID:40320649
G-CSF-Induced Emergency Granulopoiesis Modulates Neutrophil Effector Function in Mice., PMID:40299198
LPS-induced extracellular AREG triggers macrophage pyroptosis through the EGFR/TLR4 signaling pathway., PMID:40292295
Mechanical Load-Induced Upregulation of Talin2 through Non-Canonical Deubiquitination of OTUB1 Drives Facet Joint Osteoarthritis Pathogenesis., PMID:40279639
The transcription factor TSHZ3 promotes tumor immunosuppression and inhibits metastasis in lung adenocarcinoma., PMID:40264773
Tailoring osteo-immunomodulatory micro-environments via a bioactive 3D PLA scaffold to potentiate regenerative healing., PMID:40250081
Defining neuronal responses to the neurotropic parasite Toxoplasma gondii., PMID:40236177
Injectable cellular vesicle-based bone meal for inflammatory bone defect repair through restoring immune homeostasis., PMID:40225579
APOC1 expressed in macrophages promotes the pulmonary metastasis of colorectal cancer via CCL2/CCL5., PMID:40194454
Andrographolide Reduces Cytokine Release and Cyclooxygenase-2 Expression by Inhibiting the JNK and NF-κB Pathways in Glioblastoma Cells Exposed to Cadmium., PMID:40191670
Dihydroartemisinin inhibits lung cancer bone metastasis by modulating macrophage polarization., PMID:40186262
HOXC6 promotes the metastasis of MSI-H CRC by interacting with M2 macrophages and inducing effector T cell exhaustion., PMID:40186205
Suprabasin promotes gastric cancer liver metastasis via hepatic stellate cells-mediated EGF/CCL2/JAK2 intercellular signaling pathways., PMID:40181153
Sea buckthorn leaves and gallic acid inhibit C48/80-induced pseudo-allergic reaction via the PLC/IP3 signaling pathway both in vitro and in vivo., PMID:40163943
OSMR induces M2 polarization of glioblastoma associated macrophages through JAK/STAT3 signaling pathway., PMID:40161370
Axl Regulation of NK Cell Activity Creates an Immunosuppressive Tumor Immune Microenvironment in Head and Neck Cancer., PMID:40149328
Modulation of Macrophages TLR4-Mediated Transcriptional Response by Lacticaseibacillus rhamnosus CRL1505 and Lactiplantibacillus plantarum CRL1506., PMID:40141330
Low-intensity pulsed ultrasound inhibits chondrocyte senescence by inhibiting PI3K/AKT/mTOR signaling., PMID:40136230
RNA Methylation and Transcriptome Analysis Reveal Key Regulatory Pathways Related to Cadmium-Induced Liver Damage., PMID:40135526
INHBA, transcriptionally activated by SPI1, facilitates gastric cancer progression by inducing macrophage recruitment and M2 polarization via activating the TGF-β signaling to increase CCL2., PMID:40132395
Human umbilical cord mesenchymal stem cell-derived microvesicles alleviate pulmonary fibrosis by inhibiting monocyte‒macrophage migration through ERK1/2 signaling-mediated suppression of CCL2 expression., PMID:40128840
Oridonin Alleviates Doxorubicin-Induced Cardiotoxicity by Inhibiting p38 MAPK/MMP3 Signaling Pathway., PMID:40125705
Ouratein D, a Biflavanone From Ouratea spectabilis, Alleviates Betacoronavirus Infection by Mitigating Inflammation, Lung Damage and Viral Replication., PMID:40099709
The TMBIM1-YBX1 axis orchestrates MDSC recruitment and immunosuppressive microenvironment in pancreatic cancer., PMID:40083936
Alterations in Adiponectin Expression in Models of Cigarette Smoke Extract-Induced Mouse Pulmonary Emphysema and Alveolar Epithelial Cell Injury., PMID:40079477
Lactobacillus acidophilus (strain Scav) postbiotic metabolites reduce infection and modulate inflammation in an in vivo model of Pseudomonas aeruginosa wound infection., PMID:40068933
Human-induced pluripotent stem cell-derived exosomes promote skin wound healing through activating FGF2-mediated p38 pathway., PMID:40064791
Differential tissue and cellular distribution of chemokine C-C motif ligand 2 in grey/white matters of healthy and simian immunodeficiency virus infected monkey., PMID:40054539
Midkine, a novel MCP-1 activator mediated PM2.5-aggravated experimental pulmonary fibrosis., PMID:40049042
Qingre Huayu Jianpi prescription alleviates the inflammatory transformation of colitis-associated colorectal cancer by inhibiting the IL-17RA/ACT1/NF-κB axis., PMID:40043824
Mesenchymal stem cells alleviate idiopathic pneumonia syndrome by facilitating M2 polarization via CCL2/CCR2 axis and further inducing formation of regulatory CCR2 + CD4 + T cells., PMID:40025564
Extracts of Portulaca oleracea and Patrinia scabiosaefolia relieve ultraviolet B-induced skin injury in solar dermatitis mice via inhibiting IL-17/CCL2 pathway and oxidative stress., PMID:39991764
For research use only. Not for human or drug use.
