Catalog No.
VHD82301
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
IGFBP8, IGF-binding protein 8, IBP-8, CTGF, HCS24, CCN family member 2, CCN2, Cellular communication network factor 2, Hypertrophic chondrocyte-specific protein 24, Connective tissue growth factor, Insulin-like growth factor-binding protein 8, IGFBP-8
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P29279
Applications
ELISA, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0075
Hepatic stellate cell inhibition by angiotensin II receptor blocker mitigates liver injury and fibrosis via NF-κB-galectin-3 suppression in a rat nonalcoholic steatohepatitis model., PMID:40488883
Aberrant WDR5 promotes the progression of cervical cancer through the YAP1- CTGF pathway., PMID:40414554
Delivery of bone marrow mesenchymal stem cell-derived exosomes into fibroblasts attenuates intestinal fibrosis by weakening its transdifferentiation via the CCN2-TGF-β axis., PMID:40410354
Enhancing Cartilage Repair in Osteoarthritis Using Platelet Lysates and Arthroscopic Microfracture., PMID:40386186
Hyperglycemia and insulin treatment promote the proliferation of retinal pigment epithelium cells in early diabetes: an in vitro and in vivo study., PMID:40377301
A Self-Assembling LYTAC Mediates CTGF Degradation and Remodels Inflammatory Tumor Microenvironment for Triple-Negative Breast Cancer Therapy., PMID:40349150
RGD peptide hydrogel downregulates mechanosignal YAP to inhibit postoperative scarring., PMID:40318746
Dynamic-covalent hybrid hydrogels with cartilaginous immune microenvironment temporally regulating meniscus regeneration., PMID:40242503
Root of Prunus persica (taoshugen) ameliorated renal fibrosis by inhibiting TGF-β signaling via upregulating Pmepa1 in mice with unilateral ureter obstruction., PMID:40187622
Preclinical concept studies showing advantage of an inhaled anti-CTGF/CCN2 protein for pulmonary fibrosis treatment., PMID:40185752
Nephroblastoma Overexpressed Protein (NOV/CCN3) Elevated Expression of Inflammation Regulators in a Model of Sepsis-Induced Lung Injury., PMID:40156746
Depleting Yes-Associated Protein in Gli1-Expressing Cells Attenuates Peritoneal Dialysis-Induced Peritoneal Fibrosis., PMID:40133213
The transcription factor mesenchyme homeobox 1 exacerbates hepatic fibrosis by transcriptional activation of connective tissue growth factor., PMID:40073959
Desmodium caudatum (Thunb.) DC. extract attenuates hyperuricemia-induced renal fibrosis via modulating TGF-β1 pathway and uric acid transporters: Evidence from in vitro and in vivo studies., PMID:40064319
Therapeutic potential of miR-133a-transfected bone marrow mesenchymal stem cell transplantation in improving cardiac function post-myocardial infarction., PMID:39984986
YAP as a potential therapeutic target for myofibroblast formation in asthma., PMID:39939959
MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy., PMID:39901236
Single-cell transcriptome analysis revealing mechanotransduction via the Hippo/YAP pathway in promoting fibroblast-to-myofibroblast transition and idiopathic pulmonary fibrosis development., PMID:39855369
Endothelial cell (EC)-specific Ctgf/Ccn2 expression increases EC reprogramming and atherosclerosis., PMID:39818254
Interleukin-38-overexpressing adenovirus infection in dendritic cell-based treatment enhances immunotherapy for allergic asthma via inducing Foxp3+ regulatory T cells., PMID:39667222
Evaluating the efficacy and safety of polyglycolic acid-loading mitomycin nanoparticles in inhibiting the scar proliferation after glaucoma filtering surgery., PMID:39632730
Breast cancer cells promote osteoclast differentiation in an MRTF-dependent paracrine manner., PMID:39630611
Multi-omics analysis reveals the protective effects of Chinese yam polysaccharide against cisplatin-induced renal interstitial fibrosis., PMID:39603894
ER stress-induced YAP upregulation leads to chondrocyte phenotype loss in age-related osteoarthritis., PMID:39600372
The E3 ubiquitin ligase RNF6 facilitates the progression of cervical cancer by inhibiting the Hippo/Yap pathway., PMID:39551725
Yap Is a Nutrient Sensor Sensitive to the Amino Acid L-Isoleucine and Regulates the Expression of Ctgf in Cardiomyocytes., PMID:39456232
Bim Expression Influences Choroidal Endothelial Cell Characteristics and Their Response to Therapeutic Intervention., PMID:39408582
Wnt/β-Catenin Signaling Regulates Yap/Taz Activity during Embryonic Development in Zebrafish., PMID:39337493
Development of a Simvastatin-Loaded Copolymer Acid-Sensitive Nanocarrier and Its Experimental Use in the Treatment of Keloids., PMID:39313951
An ADSC-loaded dermal regeneration template promotes full-thickness wound healing., PMID:39309394
Androgen receptor activation inhibits endothelial cell migration in vitro and angiogenesis in vivo., PMID:39288691
Wenshen Xiaozheng Tang alleviates fibrosis in endometriosis by regulating differentiation and paracrine signaling of endometrium-derived mesenchymal stem cells., PMID:39181283
Suppression of NUPR1 in fibroblast-like synoviocytes reduces synovial fibrosis via the Smad3 pathway., PMID:39090667
Nobiletin alleviates macrophage M2 polarization by activating AMPK-mTOR-mediated autophagy in pulmonary fibrosis mice., PMID:39079195
Multimodal Imaging-Assisted Intravascular Theranostic Photoactivation on Atherosclerotic Plaque., PMID:38989585
Overexpressed Poldip2 Incurs Retinal Fibrosis via the TGF-β1/SMAD3 Signaling Pathway in Diabetic Retinopathy., PMID:38968428
Combination of Pirfenidone and Andrographolide Ameliorates Hepatic Stellate Cell Activation and Liver Fibrosis by Mediating TGF-β/Smad Signaling Pathway., PMID:38946862
A probe for NIR-II imaging and multimodal analysis of early Alzheimer's disease by targeting CTGF., PMID:38866763
Extracellular Vesicles Derived from Adipose Stem Cells Alleviate Systemic Sclerosis by Inhibiting TGF-β Pathway., PMID:38835111
Endometrial stem cell-derived exosomes repair cisplatin-induced premature ovarian failure via Hippo signaling pathway., PMID:38831834
Fraxinellone alleviates colitis-related intestinal fibrosis by blocking the circuit between PD-1+ Th17 cells and fibroblasts., PMID:38776854
Exposure to microcystin-LR promotes astrocyte proliferation both in vitro and in vivo via Hippo signaling pathway., PMID:38772146
The natural history of CVB3 myocarditis in C57BL/6J mice: an extended in-depth characterization., PMID:38750778
Development of alginate and alginate sulfate/polycaprolactone nanoparticles for growth factor delivery in wound healing therapy., PMID:38749174
Overexpression of zinc-finger protein 418 inhibits pathological cardiac remodelling after acute myocardial infarction., PMID:38714309
Lipid nephrotoxicity mediated by HIF-1α activation accelerates tubular injury in diabetic nephropathy., PMID:38695335
Corilagin inhibits angiotensin II-induced atrial fibrosis and fibrillation in mice through the PI3K-Akt pathway., PMID:38645493
Identification of a new class of activators of the Hippo pathway with antitumor activity in vitro and in vivo., PMID:38641306
Silymarin and MSC-exosomes ameliorate thioacetamide-evoked renal fibrosis by inhibiting TGF-β/SMAD pathway in rats., PMID:38637422
Tubuloside B, a major constituent of Cistanche deserticola, inhibits migration of hepatocellular carcinoma by inhibiting Hippo-YAP pathway., PMID:38552378
For research use only. Not for human or drug use.
