Catalog No.
VHB63201
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
BMP-10, Bone morphogenetic protein 10, BMP10
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
O95393
Applications
ELISA, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0061
BMP10 Knockdown Modulates Endothelial Cell Immunoreactivity by Inhibiting the HIF-1α Pathway in the Sepsis-Induced Myocardial Injury., PMID:39611400
Effects of maternal hypothyroidism on postnatal cardiomyocyte proliferation and cardiac disease responses of the progeny., PMID:37539452
Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers., PMID:36726183
Astragalus polysaccharides alleviates cardiac hypertrophy in diabetic cardiomyopathy via inhibiting the BMP10-mediated signaling pathway., PMID:36610158
Cardiotoxicity of sanguinarine via regulating apoptosis and MAPK pathways in zebrafish and HL1 cardiomyocytes., PMID:34744004
BMP9 and BMP10 Act Directly on Vascular Smooth Muscle Cells for Generation and Maintenance of the Contractile State., PMID:33334130
BMP10 Signaling Promotes the Development of Endocardial Cells from Human Pluripotent Stem Cell-Derived Cardiovascular Progenitors., PMID:33142114
Molecular basis of ALK1-mediated signalling by BMP9/BMP10 and their prodomain-bound forms., PMID:32238803
BMP10 preserves cardiac function through its dual activation of SMAD-mediated and STAT3-mediated pathways., PMID:31712309
Correcting Smad1/5/8, mTOR, and VEGFR2 treats pathology in hereditary hemorrhagic telangiectasia models., PMID:31689244
Structural biology of betaglycan and endoglin, membrane-bound co-receptors of the TGF-beta family., PMID:31601110
BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis., PMID:31417183
TMEM100 expression suppresses metastasis and enhances sensitivity to chemotherapy in gastric cancer., PMID:31188741
Advances in the molecular regulation of endothelial BMP9 signalling complexes and implications for cardiovascular disease., PMID:31127068
A heterodimer formed by bone morphogenetic protein 9 (BMP9) and BMP10 provides most BMP biological activity in plasma., PMID:29789425
ALK1Fc Suppresses the Human Prostate Cancer Growth in in Vitro and in Vivo Preclinical Models., PMID:29259971
Impact of selective anti-BMP9 treatment on tumor cells and tumor angiogenesis., PMID:28949445
The Prodomain-bound Form of Bone Morphogenetic Protein 10 Is Biologically Active on Endothelial Cells., PMID:26631724
Bone morphogenetic protein-10 induces cardiomyocyte proliferation and improves cardiac function after myocardial infarction., PMID:24906204
Context-dependent signaling defines roles of BMP9 and BMP10 in embryonic and postnatal development., PMID:23812757
SWI/SNF protein component BAF250a regulates cardiac progenitor cell differentiation by modulating chromatin accessibility during second heart field development., PMID:22621927
Tbx20 regulation of cardiac cell proliferation and lineage specialization during embryonic and fetal development in vivo., PMID:22226977
Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth., PMID:21737454
Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10., PMID:21550985
ALK1 as an emerging target for antiangiogenic therapy of cancer., PMID:21467543
BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo., PMID:20406889
Mutations in GDF5 reveal a key residue mediating BMP inhibition by NOGGIN., PMID:19956691
Cell therapy using articular chondrocytes overexpressing BMP-7 or BMP-10 in a rabbit disc organ culture model., PMID:18404100
Bone morphogenetic protein-9 is a circulating vascular quiescence factor., PMID:18309101
For research use only. Not for human or drug use.
