Catalog No.
VHD49501
Species reactivity
Human
Host species
Human
Isotype
IgG1, kappa
Clonality
Monoclonal
Target
VG-1-R, VG-1-related protein, Bone morphogenetic protein 6, VGR-1, BMP-6, VGR, BMP6
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P22004
Applications
ELISA, Neutralization
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
Iv0059
Note
For research use only. Not suitable for clinical or therapeutic use.
A novel autologous bone graft substitute comprised of rhBMP6 blood coagulum as carrier tested in a randomized and controlled Phase I trial in patients with distal radial fractures., PMID:32730930
Biology of bone morphogenetic protein in bone repair and regeneration: A role for autologous blood coagulum as carrier., PMID:32841742
Synergistic interaction of hTGF-β3 with hBMP-6 promotes articular cartilage formation in chitosan scaffolds with hADSCs: implications for regenerative medicine., PMID:32854680
Orphan Nuclear Receptor ERRγ Is a Novel Transcriptional Regulator of IL-6 Mediated Hepatic BMP6 Gene Expression in Mice., PMID:32998264
Possible mechanisms by which silkworm faeces extract ameliorates adenine-induced renal anaemia in rats., PMID:33022342
Suppression of the TGF-β pathway by a macrolide antibiotic decreases fibrotic responses by ocular fibroblasts in vitro., PMID:33047019
Synthetic ceramic macroporous blocks as a scaffold in ectopic bone formation induced by recombinant human bone morphogenetic protein 6 within autologous blood coagulum in rats., PMID:33052447
Gene Expression Regulation and Secretory Activity of Mesenchymal Stem Cells upon In Vitro Contact with Microarc Calcium Phosphate Coating., PMID:33081386
Endothelial specific YY1 deletion restricts tumor angiogenesis and tumor growth., PMID:33235311
Osteoinduction within adipose tissue fragments by heterodimeric bone morphogenetic Proteins-2/6 and -2/7 versus homodimeric bone morphogenetic protein-2: Therapeutic implications for bone regeneration., PMID:33527563
BMP-6 carrying metal organic framework-embedded in bioresorbable electrospun fibers for enhanced bone regeneration., PMID:33545881
Black pepper prevents anemia of inflammation by inhibiting hepcidin over-expression through BMP6-SMAD1/ IL6-STAT3 signaling pathway., PMID:33771600
Matriptase-2 and Hemojuvelin in Hepcidin Regulation: In Vivo Immunoblot Studies in Mask Mice., PMID:33800732
Alginate/chitosan modified immunomodulatory titanium implants for promoting osteogenesis in vitro and in vivo., PMID:33947577
A BMP/Activin A Chimera Induces Posterolateral Spine Fusion in Nonhuman Primates at Lower Concentrations Than BMP-2., PMID:33950879
Calcitonin increases hepatic hepcidin expression through the BMP6 of kidney in mice., PMID:34098241
Eucommia ulmoides Polysaccharides Attenuate Rabbit Osteoarthritis by Regulating the Function of Macrophages., PMID:34421623
Differentiation Behaviour of Adipose-Derived Stromal Cells (ASCs) Seeded on Polyurethane-Fibrin Scaffolds In Vitro and In Vivo., PMID:34440186
Bone morphogenetic protein 6-mediated crosstalk between endothelial cells and hepatocytes recapitulates the iron-sensing pathway in vitro., PMID:34740612
Evolved Bmp6 enhancer alleles drive spatial shifts in gene expression during tooth development in sticklebacks., PMID:34849839
Foxp1 and Foxp4 Deletion Causes the Loss of Follicle Stem Cell Niche and Cyclic Hair Shedding by Inducing Inner Bulge Cell Apoptosis., PMID:35759955
Differential effects of Smad2 and Smad3 in regulation of macrophage phenotype and function in the infarcted myocardium., PMID:35780861
Glycochenodeoxycholate Affects Iron Homeostasis via Up-Regulating Hepcidin Expression., PMID:35956351
The use of heparin/polycation coacervate sustain release system to compare the bone regenerative potentials of 5 BMPs using a critical sized calvarial bone defect model., PMID:36031459
NORAD promotes multiple myeloma cell progression via BMP6/P-ERK1/2 axis., PMID:36126794
Anticeramide Improves Sjögren's Syndrome by Blocking BMP6-Induced Th1., PMID:36281063
iPSC-neural crest derived cells embedded in 3D printable bio-ink promote cranial bone defect repair., PMID:36333414
Iron metabolism disorder regulated by BMP signaling in hypoxic pulmonary hypertension., PMID:36343841
Genesis of osteoclasts on calcium phosphate ceramics and their role in material-induced bone formation., PMID:36371003
Formation and characterization of BMP2/GDF5 and BMP4/GDF5 heterodimers., PMID:36726183
The hepatokine FGL1 regulates hepcidin and iron metabolism during the recovery from hemorrhage-induced anemia in mice., PMID:37066218
FKBP12 inhibits hepcidin expression by modulating BMP receptors interaction and ligand responsiveness in hepatocytes., PMID:37199280
H3K27me3-modulated Hofbauer cell BMP2 signalling enhancement compensates for shallow trophoblast invasion in preeclampsia., PMID:37331163
CREB-H is a stress-regulator of hepcidin gene expression during early postnatal development., PMID:37493829
An H2 S-BMP6 Dual-Loading System with Regulating Yap/Taz and Jun Pathway for Synergistic Critical Limb Ischemia Salvaging Therapy., PMID:37531238
Knockdown of Bach1 protects periodontal bone regeneration from inflammatory damage., PMID:37602966
Superoxide dismutase 2 scavenges ROS to promote osteogenic differentiation of human periodontal ligament stem cells by regulating Smad3 in alveolar bone-defective rats., PMID:37921754
BMP-ACVR1 Axis is Critical for Efficacy of PRC2 Inhibitors in B-Cell Lymphoma., PMID:38229201
The hepatokine FGL1 regulates hepcidin and iron metabolism during anemia in mice by antagonizing BMP signaling., PMID:38232308
Improvement of Mouse Preantral Follicle Survival and Development following Co-Culture with Ovarian Parenchyma Cell Suspension., PMID:38368519
Serum Iron Overload Activates the SMAD Pathway and Hepcidin Expression of Hepatocytes via SMURF1., PMID:38426189
BMP6 inhibits gastric cancer growth and predicts good prognosis., PMID:38482225
Silibinin is a suppressor of the metastasis-promoting transcription factor ID3., PMID:38484626
The BMP2 prodomain promotes dimerization and cleavage of BMP6 homodimers and BMP2/6 heterodimers in vivo., PMID:38948827
miR-455/GREM1 axis promotes colorectal cancer progression and liver metastasis by affecting PI3K/AKT pathway and inducing M2 macrophage polarization., PMID:38970064
The Influence of BMP6 on Serotonin and Glucose Metabolism., PMID:39063084
Sevuparin strongly reduces hepcidin expression in cells, mice, and healthy human volunteers., PMID:39619244
The GPR30-Mediated BMP-6/HEP/FPN Signaling Pathway Inhibits Ferroptosis in Bone Marrow Mesenchymal Stem Cells to Alleviate Osteoporosis., PMID:40076648
LncRNA MRF targeting FSHR inhibits the osteogenic differentiation of BMSCs and bone defect repair through the regulation of the cAMP-PKA-CREB signaling pathway., PMID:40264197
Melatonin Promotes Cerebral Angiogenesis in Ischemic Mice via BMP6/Smad1/5/9 Pathway., PMID:40274709
For research use only. Not for human or drug use.
